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Comparison of potency of ephedrine and mephentermine for prevention of post-spinal hypotension in caesarean section.
Anaesth Intensive Care. 2008 May; 36(3):360-4.AI

Abstract

The dosages and potency of intravenous mephentermine for prevention of post-spinal hypotension are not available in English literature. This study was designed to determine the minimum effective dose (ED50) of mephentermine and to compare its potency with that of ephedrine for prevention of post-spinal hypotension in parturients undergoing caesarean section. Dixon's up-down method of sequential allocation was used for vasopressor doses. Following administration of spinal anaesthesia, patients received a prophylactic infusion with 50 mg infused over a period of 30 minutes as the initial dose and dose intervals of 5 mg, of either ephedrine or mephentermine. The ED50 of ephedrine was 25.0 mg (95% CI 15.5 to 40.4 mg). For mephentermine, the up-down method was abandoned due to the success of the minimum dose possible but the ED50 appeared to be less than 5 mg. In conclusion, the minimum effective dose of mephentermine is much less than that of ephedrine for prevention of post-spinal hypotension. Another trial with a lower starting dose and smaller dose interval of mephentermine is required to determine the potency ratio of mephentermine and ephedrine.

Authors+Show Affiliations

Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18564796

Citation

Mohta, M, et al. "Comparison of Potency of Ephedrine and Mephentermine for Prevention of Post-spinal Hypotension in Caesarean Section." Anaesthesia and Intensive Care, vol. 36, no. 3, 2008, pp. 360-4.
Mohta M, Agarwal D, Gupta LK, et al. Comparison of potency of ephedrine and mephentermine for prevention of post-spinal hypotension in caesarean section. Anaesth Intensive Care. 2008;36(3):360-4.
Mohta, M., Agarwal, D., Gupta, L. K., Tyagi, A., Gupta, A., & Sethi, A. K. (2008). Comparison of potency of ephedrine and mephentermine for prevention of post-spinal hypotension in caesarean section. Anaesthesia and Intensive Care, 36(3), 360-4.
Mohta M, et al. Comparison of Potency of Ephedrine and Mephentermine for Prevention of Post-spinal Hypotension in Caesarean Section. Anaesth Intensive Care. 2008;36(3):360-4. PubMed PMID: 18564796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of potency of ephedrine and mephentermine for prevention of post-spinal hypotension in caesarean section. AU - Mohta,M, AU - Agarwal,D, AU - Gupta,L K, AU - Tyagi,A, AU - Gupta,A, AU - Sethi,A K, PY - 2008/6/21/pubmed PY - 2008/9/26/medline PY - 2008/6/21/entrez SP - 360 EP - 4 JF - Anaesthesia and intensive care JO - Anaesth Intensive Care VL - 36 IS - 3 N2 - The dosages and potency of intravenous mephentermine for prevention of post-spinal hypotension are not available in English literature. This study was designed to determine the minimum effective dose (ED50) of mephentermine and to compare its potency with that of ephedrine for prevention of post-spinal hypotension in parturients undergoing caesarean section. Dixon's up-down method of sequential allocation was used for vasopressor doses. Following administration of spinal anaesthesia, patients received a prophylactic infusion with 50 mg infused over a period of 30 minutes as the initial dose and dose intervals of 5 mg, of either ephedrine or mephentermine. The ED50 of ephedrine was 25.0 mg (95% CI 15.5 to 40.4 mg). For mephentermine, the up-down method was abandoned due to the success of the minimum dose possible but the ED50 appeared to be less than 5 mg. In conclusion, the minimum effective dose of mephentermine is much less than that of ephedrine for prevention of post-spinal hypotension. Another trial with a lower starting dose and smaller dose interval of mephentermine is required to determine the potency ratio of mephentermine and ephedrine. SN - 0310-057X UR - https://www.unboundmedicine.com/medline/citation/18564796/Comparison_of_potency_of_ephedrine_and_mephentermine_for_prevention_of_post_spinal_hypotension_in_caesarean_section_ L2 - http://journals.sagepub.com/doi/full/10.1177/0310057X0803600306?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -