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Spray drying TB vaccines for pulmonary administration.
Expert Opin Biol Ther 2008; 8(7):857-63EO

Abstract

BACKGROUND

New developments in materials science provide innovative technologies that allow mucosal immunization against tuberculosis. Recent studies report that spray-drying Mycobacterium bovis Bacillus Calmette-Guérin (BCG) allows efficient aerosol delivery of TB vaccines to the lung.

OBJECTIVES

To consider powder formulation of BCG for inhalation by spray-drying and its potential application to other vaccines given the unique challenges in the process, formulation and delivery.

METHODS

Description of current advances in spray-drying and aerosol delivery, and its application to preparation of BCG TB vaccine for inhalation. Special consideration is given to physical properties, viability, stability and delivery aspects.

RESULTS/CONCLUSION

Spray-drying generates powders with excellent dispersion qualities suitable for targeted delivery to the deep lung. TB vaccine for inhalation prepared by spray-drying is feasible, low-cost and pharmaceutically scaleable.

Authors+Show Affiliations

Chief Scientific Officer Medicine in Need (Mend), MRC Building, PO Box 12660, Queenswood, 0121 Pretoria, South Africa. bfourie@medicineinneed.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18564902

Citation

Fourie, P B., et al. "Spray Drying TB Vaccines for Pulmonary Administration." Expert Opinion On Biological Therapy, vol. 8, no. 7, 2008, pp. 857-63.
Fourie PB, Germishuizen WA, Wong YL, et al. Spray drying TB vaccines for pulmonary administration. Expert Opin Biol Ther. 2008;8(7):857-63.
Fourie, P. B., Germishuizen, W. A., Wong, Y. L., & Edwards, D. A. (2008). Spray drying TB vaccines for pulmonary administration. Expert Opinion On Biological Therapy, 8(7), pp. 857-63. doi:10.1517/14712598.8.7.857.
Fourie PB, et al. Spray Drying TB Vaccines for Pulmonary Administration. Expert Opin Biol Ther. 2008;8(7):857-63. PubMed PMID: 18564902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spray drying TB vaccines for pulmonary administration. AU - Fourie,P B, AU - Germishuizen,W A, AU - Wong,Y-L, AU - Edwards,D A, PY - 2008/6/21/pubmed PY - 2008/7/31/medline PY - 2008/6/21/entrez SP - 857 EP - 63 JF - Expert opinion on biological therapy JO - Expert Opin Biol Ther VL - 8 IS - 7 N2 - BACKGROUND: New developments in materials science provide innovative technologies that allow mucosal immunization against tuberculosis. Recent studies report that spray-drying Mycobacterium bovis Bacillus Calmette-Guérin (BCG) allows efficient aerosol delivery of TB vaccines to the lung. OBJECTIVES: To consider powder formulation of BCG for inhalation by spray-drying and its potential application to other vaccines given the unique challenges in the process, formulation and delivery. METHODS: Description of current advances in spray-drying and aerosol delivery, and its application to preparation of BCG TB vaccine for inhalation. Special consideration is given to physical properties, viability, stability and delivery aspects. RESULTS/CONCLUSION: Spray-drying generates powders with excellent dispersion qualities suitable for targeted delivery to the deep lung. TB vaccine for inhalation prepared by spray-drying is feasible, low-cost and pharmaceutically scaleable. SN - 1744-7682 UR - https://www.unboundmedicine.com/medline/citation/18564902/Spray_drying_TB_vaccines_for_pulmonary_administration_ L2 - http://www.tandfonline.com/doi/full/10.1517/14712598.8.7.857 DB - PRIME DP - Unbound Medicine ER -