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Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system.
Eur J Pharmacol 2008; 589(1-3):117-21EJ

Abstract

In the present study, we investigated the effect of Delta(9)-tetrahydrocannabinol (THC), the principal psychoactive component of marijuana, on immobility time during the forced swim test. THC (2 and 6 mg/kg, i.p.) significantly prolonged the immobility time. In addition, THC at the same doses did not significantly affect locomotor activity in the open-field test. The selective cannabinoid CB(1) receptor antagonist rimonabant (3 mg/kg, i.p.) significantly reduced the enhancement of immobility by THC (6 mg/kg). Similarly, the selective serotonin (5-HT) reuptake inhibitor (SSRI) citalopram (10 mg/kg, i.p.) and 5-HT(1A/7) receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT, 0.3 mg/kg, i.p.) significantly reduced this THC-induced effect. Moreover, the selective 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane carboxamide dihydrochloride (WAY100635, 1 mg/kg, i.p.) and the postsynaptic 5-HT(1A) receptor antagonist MM-77 (0.1 mg/kg, i.p.) reversed this reduction effect of 8-OH-DPAT (0.3 mg/kg). In contrast, the selective 5-HT(7) receptor antagonist (R)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride (SB269970) had no effect on this reduction effect of 8-OH-DPAT. WAY100635 (1 mg/kg) also reversed the reduction effect of citalopram (10 mg/kg). These findings suggest that the 5-HT(1A) receptors are involved in THC-induced enhancement of immobility.

Authors+Show Affiliations

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18565508

Citation

Egashira, Nobuaki, et al. "Delta(9)-tetrahydrocannabinol Prolongs the Immobility Time in the Mouse Forced Swim Test: Involvement of Cannabinoid CB(1) Receptor and Serotonergic System." European Journal of Pharmacology, vol. 589, no. 1-3, 2008, pp. 117-21.
Egashira N, Matsuda T, Koushi E, et al. Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system. Eur J Pharmacol. 2008;589(1-3):117-21.
Egashira, N., Matsuda, T., Koushi, E., Higashihara, F., Mishima, K., Chidori, S., ... Fujiwara, M. (2008). Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system. European Journal of Pharmacology, 589(1-3), pp. 117-21. doi:10.1016/j.ejphar.2008.03.046.
Egashira N, et al. Delta(9)-tetrahydrocannabinol Prolongs the Immobility Time in the Mouse Forced Swim Test: Involvement of Cannabinoid CB(1) Receptor and Serotonergic System. Eur J Pharmacol. 2008 Jul 28;589(1-3):117-21. PubMed PMID: 18565508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system. AU - Egashira,Nobuaki, AU - Matsuda,Tomomi, AU - Koushi,Emi, AU - Higashihara,Fuminori, AU - Mishima,Kenichi, AU - Chidori,Shozo, AU - Hasebe,Nobuyoshi, AU - Iwasaki,Katsunori, AU - Nishimura,Ryoji, AU - Oishi,Ryozo, AU - Fujiwara,Michihiro, Y1 - 2008/04/08/ PY - 2007/07/02/received PY - 2008/03/07/revised PY - 2008/03/27/accepted PY - 2008/6/21/pubmed PY - 2008/10/25/medline PY - 2008/6/21/entrez SP - 117 EP - 21 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 589 IS - 1-3 N2 - In the present study, we investigated the effect of Delta(9)-tetrahydrocannabinol (THC), the principal psychoactive component of marijuana, on immobility time during the forced swim test. THC (2 and 6 mg/kg, i.p.) significantly prolonged the immobility time. In addition, THC at the same doses did not significantly affect locomotor activity in the open-field test. The selective cannabinoid CB(1) receptor antagonist rimonabant (3 mg/kg, i.p.) significantly reduced the enhancement of immobility by THC (6 mg/kg). Similarly, the selective serotonin (5-HT) reuptake inhibitor (SSRI) citalopram (10 mg/kg, i.p.) and 5-HT(1A/7) receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT, 0.3 mg/kg, i.p.) significantly reduced this THC-induced effect. Moreover, the selective 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane carboxamide dihydrochloride (WAY100635, 1 mg/kg, i.p.) and the postsynaptic 5-HT(1A) receptor antagonist MM-77 (0.1 mg/kg, i.p.) reversed this reduction effect of 8-OH-DPAT (0.3 mg/kg). In contrast, the selective 5-HT(7) receptor antagonist (R)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride (SB269970) had no effect on this reduction effect of 8-OH-DPAT. WAY100635 (1 mg/kg) also reversed the reduction effect of citalopram (10 mg/kg). These findings suggest that the 5-HT(1A) receptors are involved in THC-induced enhancement of immobility. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/18565508/Delta_9__tetrahydrocannabinol_prolongs_the_immobility_time_in_the_mouse_forced_swim_test:_involvement_of_cannabinoid_CB_1__receptor_and_serotonergic_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(08)00380-4 DB - PRIME DP - Unbound Medicine ER -