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Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling.
Stem Cells. 2008 Sep; 26(9):2372-81.SC

Abstract

CD137 is a member of the tumor necrosis factor receptor family and is involved in the regulation of activation, proliferation, differentiation, and cell death of leukocytes. Bidirectional signaling exists for the CD137 receptor/ligand system, as CD137 ligand, which is expressed as a transmembrane protein, can also transduce signals into the cells on which it is expressed. In this study, we have identified expression of CD137 in human bone marrow and expression of CD137 ligand on a subset of CD34+ cells. Cross-linking of CD137 ligand on CD34+ cells by CD137 ligand agonists induces activation, prolongation of survival, proliferation, and colony formation. CD137 ligand agonists induce differentiation of early hematopoietic progenitor cells to colony-forming units-granulocyte/macrophage and subsequently to monocytes and macrophages but not to dendritic cells. These data uncover a novel function of CD137 and CD137 ligand by showing their participation in the growth and differentiation of hematopoietic progenitor cells.

Authors+Show Affiliations

Department of Physiology, and Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18566330

Citation

Jiang, Dongsheng, et al. "Induction of Proliferation and Monocytic Differentiation of Human CD34+ Cells By CD137 Ligand Signaling." Stem Cells (Dayton, Ohio), vol. 26, no. 9, 2008, pp. 2372-81.
Jiang D, Yue PS, Drenkard D, et al. Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Stem Cells. 2008;26(9):2372-81.
Jiang, D., Yue, P. S., Drenkard, D., & Schwarz, H. (2008). Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Stem Cells (Dayton, Ohio), 26(9), 2372-81. https://doi.org/10.1634/stemcells.2008-0158
Jiang D, et al. Induction of Proliferation and Monocytic Differentiation of Human CD34+ Cells By CD137 Ligand Signaling. Stem Cells. 2008;26(9):2372-81. PubMed PMID: 18566330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. AU - Jiang,Dongsheng, AU - Yue,Pei Shan Eunice, AU - Drenkard,Daniela, AU - Schwarz,Herbert, Y1 - 2008/06/19/ PY - 2008/6/21/pubmed PY - 2009/2/12/medline PY - 2008/6/21/entrez SP - 2372 EP - 81 JF - Stem cells (Dayton, Ohio) JO - Stem Cells VL - 26 IS - 9 N2 - CD137 is a member of the tumor necrosis factor receptor family and is involved in the regulation of activation, proliferation, differentiation, and cell death of leukocytes. Bidirectional signaling exists for the CD137 receptor/ligand system, as CD137 ligand, which is expressed as a transmembrane protein, can also transduce signals into the cells on which it is expressed. In this study, we have identified expression of CD137 in human bone marrow and expression of CD137 ligand on a subset of CD34+ cells. Cross-linking of CD137 ligand on CD34+ cells by CD137 ligand agonists induces activation, prolongation of survival, proliferation, and colony formation. CD137 ligand agonists induce differentiation of early hematopoietic progenitor cells to colony-forming units-granulocyte/macrophage and subsequently to monocytes and macrophages but not to dendritic cells. These data uncover a novel function of CD137 and CD137 ligand by showing their participation in the growth and differentiation of hematopoietic progenitor cells. SN - 1549-4918 UR - https://www.unboundmedicine.com/medline/citation/18566330/Induction_of_proliferation_and_monocytic_differentiation_of_human_CD34+_cells_by_CD137_ligand_signaling_ L2 - https://doi.org/10.1634/stemcells.2008-0158 DB - PRIME DP - Unbound Medicine ER -