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A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials.

Abstract

Panax ginseng C.A. Meyer is a well-known medicinal herb native to China and Korea, and has been used as a herbal remedy in eastern Asia for thousands of years. However, there is different evidence of ginseng efficacy between traditional Chinese medicine (TCM), modern pharmacological experiments and clinical trials. In TCM, ginseng is a highly valued herb and has been applied to a variety of pathological conditions and illnesses such as hypodynamia, anorexia, shortness of breath, palpitation, insomnia, impotence, hemorrhage and diabetes. Modern pharmacological experiments have proved that ginseng possesses multiple constituents (ginsenosides, polysaccharides, peptides, polyacetylenic alcohols, etc.) and actions (central nervous system effects, neuroprotective effect, immunomodulation, anticancer, etc.), ginsenosides as the active ingredients, especially, having antioxidant, antiinflammatory, antiapoptotic and immunostimulant properties. Recently, ginseng has been studied in a number of randomized controlled trials investigating its effect mainly on physical and psychomotor performance, cognitive function, immunomodulation, diabetes mellitus, cardiovascular risk factors, quality of life, as well as adverse effects. Equivocal results have been demonstrated for many of these indications. Because of the poor quality of most clinical trials on ginseng, reliable clinical data in humans are still lacking. Therefore, a broader understanding of medical knowledge and reasoning on ginseng is necessary.

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  • Authors+Show Affiliations

    ,

    TCM Research Center, Tianjin University of Traditional Chinese Medicine, Anshanxi Road 312, Nankai District, Tianjin, 300193, China.

    , ,

    Source

    Phytotherapy research : PTR 22:7 2008 Jul pg 851-8

    MeSH

    Drugs, Chinese Herbal
    History, 20th Century
    History, 21st Century
    History, Ancient
    Medicine, Chinese Traditional
    Panax
    Phytotherapy
    Plant Extracts
    Randomized Controlled Trials as Topic

    Pub Type(s)

    Comparative Study
    Historical Article
    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    18567057

    Citation

    Xiang, Yao-Zu, et al. "A Comparison of the Ancient Use of Ginseng in Traditional Chinese Medicine With Modern Pharmacological Experiments and Clinical Trials." Phytotherapy Research : PTR, vol. 22, no. 7, 2008, pp. 851-8.
    Xiang YZ, Shang HC, Gao XM, et al. A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytother Res. 2008;22(7):851-8.
    Xiang, Y. Z., Shang, H. C., Gao, X. M., & Zhang, B. L. (2008). A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytotherapy Research : PTR, 22(7), pp. 851-8. doi:10.1002/ptr.2384.
    Xiang YZ, et al. A Comparison of the Ancient Use of Ginseng in Traditional Chinese Medicine With Modern Pharmacological Experiments and Clinical Trials. Phytother Res. 2008;22(7):851-8. PubMed PMID: 18567057.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. AU - Xiang,Yao-Zu, AU - Shang,Hong-Cai, AU - Gao,Xiu-Mei, AU - Zhang,Bo-Li, PY - 2008/6/21/pubmed PY - 2008/8/8/medline PY - 2008/6/21/entrez SP - 851 EP - 8 JF - Phytotherapy research : PTR JO - Phytother Res VL - 22 IS - 7 N2 - Panax ginseng C.A. Meyer is a well-known medicinal herb native to China and Korea, and has been used as a herbal remedy in eastern Asia for thousands of years. However, there is different evidence of ginseng efficacy between traditional Chinese medicine (TCM), modern pharmacological experiments and clinical trials. In TCM, ginseng is a highly valued herb and has been applied to a variety of pathological conditions and illnesses such as hypodynamia, anorexia, shortness of breath, palpitation, insomnia, impotence, hemorrhage and diabetes. Modern pharmacological experiments have proved that ginseng possesses multiple constituents (ginsenosides, polysaccharides, peptides, polyacetylenic alcohols, etc.) and actions (central nervous system effects, neuroprotective effect, immunomodulation, anticancer, etc.), ginsenosides as the active ingredients, especially, having antioxidant, antiinflammatory, antiapoptotic and immunostimulant properties. Recently, ginseng has been studied in a number of randomized controlled trials investigating its effect mainly on physical and psychomotor performance, cognitive function, immunomodulation, diabetes mellitus, cardiovascular risk factors, quality of life, as well as adverse effects. Equivocal results have been demonstrated for many of these indications. Because of the poor quality of most clinical trials on ginseng, reliable clinical data in humans are still lacking. Therefore, a broader understanding of medical knowledge and reasoning on ginseng is necessary. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/18567057/A_comparison_of_the_ancient_use_of_ginseng_in_traditional_Chinese_medicine_with_modern_pharmacological_experiments_and_clinical_trials_ L2 - https://doi.org/10.1002/ptr.2384 DB - PRIME DP - Unbound Medicine ER -