Tags

Type your tag names separated by a space and hit enter

Asymmetric aldol reactions catalyzed by efficient and recyclable silica-supported proline-based peptides.
Chirality. 2009 Apr; 21(4):413-20.C

Abstract

A series of silica-supported proline-based peptides were synthesized and applied as catalysts for direct asymmetric intermolecular aldol reactions. Among these, a peptide with two L-proline units was found to be the most efficient one for the asymmetric aldol reactions between acetone and aromatic aldehydes. The reactions generated the corresponding products with satisfactory isolated yields (up to 97%) and enantiomeric excesses (up to 96%) in the presence of this catalyst (5 mol %). Furthermore, the silica-supported organocatalyst could be recovered and recycled by a simple filtration of the reaction solution and used for five consecutive trials without loss of its reactivity.

Authors+Show Affiliations

Department of Chemistry, Huaibei Coal Teachers College, Anhui, People's Republic of China.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18570310

Citation

Yan, Jincan, and Lei Wang. "Asymmetric Aldol Reactions Catalyzed By Efficient and Recyclable Silica-supported Proline-based Peptides." Chirality, vol. 21, no. 4, 2009, pp. 413-20.
Yan J, Wang L. Asymmetric aldol reactions catalyzed by efficient and recyclable silica-supported proline-based peptides. Chirality. 2009;21(4):413-20.
Yan, J., & Wang, L. (2009). Asymmetric aldol reactions catalyzed by efficient and recyclable silica-supported proline-based peptides. Chirality, 21(4), 413-20. https://doi.org/10.1002/chir.20603
Yan J, Wang L. Asymmetric Aldol Reactions Catalyzed By Efficient and Recyclable Silica-supported Proline-based Peptides. Chirality. 2009;21(4):413-20. PubMed PMID: 18570310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymmetric aldol reactions catalyzed by efficient and recyclable silica-supported proline-based peptides. AU - Yan,Jincan, AU - Wang,Lei, PY - 2008/6/24/pubmed PY - 2009/8/25/medline PY - 2008/6/24/entrez SP - 413 EP - 20 JF - Chirality JO - Chirality VL - 21 IS - 4 N2 - A series of silica-supported proline-based peptides were synthesized and applied as catalysts for direct asymmetric intermolecular aldol reactions. Among these, a peptide with two L-proline units was found to be the most efficient one for the asymmetric aldol reactions between acetone and aromatic aldehydes. The reactions generated the corresponding products with satisfactory isolated yields (up to 97%) and enantiomeric excesses (up to 96%) in the presence of this catalyst (5 mol %). Furthermore, the silica-supported organocatalyst could be recovered and recycled by a simple filtration of the reaction solution and used for five consecutive trials without loss of its reactivity. SN - 1520-636X UR - https://www.unboundmedicine.com/medline/citation/18570310/Asymmetric_aldol_reactions_catalyzed_by_efficient_and_recyclable_silica_supported_proline_based_peptides_ L2 - https://doi.org/10.1002/chir.20603 DB - PRIME DP - Unbound Medicine ER -