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Hepatic disorders severely affected by pregnancy: medical and obstetric management.
Med Clin North Am. 2008 Jul; 92(4):739-60, vii-viii.MC

Abstract

Hepatic disorders severely affected by pregnancy include choledochal cysts that can be compressed by the gravid uterus and potentially rupture; hepatic adenomas that exhibit accelerated growth because of hyperestrogenemia during pregnancy; acute intermittent porphyria that is exacerbated by increased female sex hormones during pregnancy; splenic artery aneurysms that can rupture during pregnancy because of compression by the gravid uterus; Budd-Chiari syndrome that is promoted by hyperestrogenemia; and hepatitis E and herpes simplex hepatitis that are particularly severe during pregnancy. Hepatic disorders unique to pregnancy include intrahepatic cholestasis of pregnancy; acute fatty liver of pregnancy; preeclampsia and eclampsia; and hemolysis, elevated liver function tests, and low platelet count (HELLP) syndrome. Most disorders uniquely related to pregnancy are treated by prompt fetal delivery as soon as the fetus is sufficiently mature.

Authors+Show Affiliations

Division of Gastroenterology, Department of Medicine, William Beaumont Hospital, MOB 233, 3535 West Thirteen Mile Road, Royal Oak, MI 48073, USA. mscappell@yahoo.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18570941

Citation

Cappell, Mitchell S.. "Hepatic Disorders Severely Affected By Pregnancy: Medical and Obstetric Management." The Medical Clinics of North America, vol. 92, no. 4, 2008, pp. 739-60, vii-viii.
Cappell MS. Hepatic disorders severely affected by pregnancy: medical and obstetric management. Med Clin North Am. 2008;92(4):739-60, vii-viii.
Cappell, M. S. (2008). Hepatic disorders severely affected by pregnancy: medical and obstetric management. The Medical Clinics of North America, 92(4), 739-60, vii-viii. https://doi.org/10.1016/j.mcna.2008.03.002
Cappell MS. Hepatic Disorders Severely Affected By Pregnancy: Medical and Obstetric Management. Med Clin North Am. 2008;92(4):739-60, vii-viii. PubMed PMID: 18570941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic disorders severely affected by pregnancy: medical and obstetric management. A1 - Cappell,Mitchell S, PY - 2008/6/24/pubmed PY - 2008/9/26/medline PY - 2008/6/24/entrez SP - 739-60, vii-viii JF - The Medical clinics of North America JO - Med Clin North Am VL - 92 IS - 4 N2 - Hepatic disorders severely affected by pregnancy include choledochal cysts that can be compressed by the gravid uterus and potentially rupture; hepatic adenomas that exhibit accelerated growth because of hyperestrogenemia during pregnancy; acute intermittent porphyria that is exacerbated by increased female sex hormones during pregnancy; splenic artery aneurysms that can rupture during pregnancy because of compression by the gravid uterus; Budd-Chiari syndrome that is promoted by hyperestrogenemia; and hepatitis E and herpes simplex hepatitis that are particularly severe during pregnancy. Hepatic disorders unique to pregnancy include intrahepatic cholestasis of pregnancy; acute fatty liver of pregnancy; preeclampsia and eclampsia; and hemolysis, elevated liver function tests, and low platelet count (HELLP) syndrome. Most disorders uniquely related to pregnancy are treated by prompt fetal delivery as soon as the fetus is sufficiently mature. SN - 0025-7125 UR - https://www.unboundmedicine.com/medline/citation/18570941/Hepatic_disorders_severely_affected_by_pregnancy:_medical_and_obstetric_management_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-7125(08)00029-1 DB - PRIME DP - Unbound Medicine ER -