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Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children.
Diabetes Res Clin Pract. 2008 Sep; 81(3):321-6.DR

Abstract

There has been increasing number of obese children who accompany obesity-related comorbidities. It has been known that nonalcoholic fatty liver disease (NAFLD) as one of obesity-related comorbidities is related with insulin resistance. So, we investigated the relation between insulin resistance and NAFLD, using serum alanine aminotransferase (ALT) as a surrogate of NAFLD among obese children in Korea. The study subjects were 909 obese children aged 9-12 years (boys 613, girls 296). Body mass index (BMI), waist circumference (WC), blood pressure, fasting blood glucose, fasting insulin, lipid profile were measured. ALT, liver enzyme was used as a surrogate of NAFLD and homeostasis model assessment of insulin resistance (HOMA-IR) was used as the index of insulin resistance. The prevalence of elevated serum ALT (>or=40 mg/dl) was 33.4% in boys, and 19.6% in girls respectively. In boys, ALT was correlated with BMI, waist circumference, total cholesterol, triglyceride, HDL-cholesterol, systolic and diastolic blood pressure, HOMA-IR, fasting serum insulin. Odds ratio for HOMA-IR against the elevated ALT (>or=40 mg/dl) was 1.061 (95% confidence interval, 1.020-1.103, P=0.003). In girls, ALT was correlated with BMI, waist circumference, total cholesterol, triglyceride, glucose, systolic and diastolic blood pressure, HOMA-IR, fasting serum insulin. Odds ratio for HOMA-IR against the elevated ALT (>or=40 mg/dl) was 1.042 (95% confidence interval, 0.998-1.088, P=0.063). Among obese Korean children, insulin resistance and ALT, lipid profile, BMI, WC, blood pressure showed significant correlation. Especially, in boys, higher ALT is founded to be independently associated with insulin resistance.

Authors+Show Affiliations

Department of Family Medicine, Inje University, College of Medicine, Sanggyepaik Hospital, Nowon-Gu, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18571268

Citation

Yoo, JangSuk, et al. "Relationship Between Insulin Resistance and Serum Alanine Aminotransferase as a Surrogate of NAFLD (nonalcoholic Fatty Liver Disease) in Obese Korean Children." Diabetes Research and Clinical Practice, vol. 81, no. 3, 2008, pp. 321-6.
Yoo J, Lee S, Kim K, et al. Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children. Diabetes Res Clin Pract. 2008;81(3):321-6.
Yoo, J., Lee, S., Kim, K., Yoo, S., Sung, E., & Yim, J. (2008). Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children. Diabetes Research and Clinical Practice, 81(3), 321-6. https://doi.org/10.1016/j.diabres.2008.05.006
Yoo J, et al. Relationship Between Insulin Resistance and Serum Alanine Aminotransferase as a Surrogate of NAFLD (nonalcoholic Fatty Liver Disease) in Obese Korean Children. Diabetes Res Clin Pract. 2008;81(3):321-6. PubMed PMID: 18571268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children. AU - Yoo,JangSuk, AU - Lee,SeonYeong, AU - Kim,KyuNam, AU - Yoo,SunMi, AU - Sung,EunJu, AU - Yim,JungEun, Y1 - 2008/06/20/ PY - 2007/11/26/received PY - 2008/04/18/revised PY - 2008/05/01/accepted PY - 2008/6/24/pubmed PY - 2008/11/19/medline PY - 2008/6/24/entrez SP - 321 EP - 6 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 81 IS - 3 N2 - There has been increasing number of obese children who accompany obesity-related comorbidities. It has been known that nonalcoholic fatty liver disease (NAFLD) as one of obesity-related comorbidities is related with insulin resistance. So, we investigated the relation between insulin resistance and NAFLD, using serum alanine aminotransferase (ALT) as a surrogate of NAFLD among obese children in Korea. The study subjects were 909 obese children aged 9-12 years (boys 613, girls 296). Body mass index (BMI), waist circumference (WC), blood pressure, fasting blood glucose, fasting insulin, lipid profile were measured. ALT, liver enzyme was used as a surrogate of NAFLD and homeostasis model assessment of insulin resistance (HOMA-IR) was used as the index of insulin resistance. The prevalence of elevated serum ALT (>or=40 mg/dl) was 33.4% in boys, and 19.6% in girls respectively. In boys, ALT was correlated with BMI, waist circumference, total cholesterol, triglyceride, HDL-cholesterol, systolic and diastolic blood pressure, HOMA-IR, fasting serum insulin. Odds ratio for HOMA-IR against the elevated ALT (>or=40 mg/dl) was 1.061 (95% confidence interval, 1.020-1.103, P=0.003). In girls, ALT was correlated with BMI, waist circumference, total cholesterol, triglyceride, glucose, systolic and diastolic blood pressure, HOMA-IR, fasting serum insulin. Odds ratio for HOMA-IR against the elevated ALT (>or=40 mg/dl) was 1.042 (95% confidence interval, 0.998-1.088, P=0.063). Among obese Korean children, insulin resistance and ALT, lipid profile, BMI, WC, blood pressure showed significant correlation. Especially, in boys, higher ALT is founded to be independently associated with insulin resistance. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18571268/Relationship_between_insulin_resistance_and_serum_alanine_aminotransferase_as_a_surrogate_of_NAFLD__nonalcoholic_fatty_liver_disease__in_obese_Korean_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(08)00234-9 DB - PRIME DP - Unbound Medicine ER -