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Is fasting glucose variability a risk factor for retinopathy in people with type 2 diabetes?
Nutr Metab Cardiovasc Dis 2009; 19(5):334-9NM

Abstract

AIMS

Fasting plasma glucose variability strongly predicts the incidence of cardiovascular events in type 2 diabetic patients. We prospectively assessed whether fasting plasma glucose variability predicts the development/progression of retinopathy in a large cohort of type 2 diabetic outpatients.

METHODS

In the period 1996-1999, 1019 type 2 diabetic participants (aged 69+/-11 years) in the Verona Diabetes Study underwent at least 3 fasting plasma glucose (FPG) determinations and an eye examination by retinography. Of these, 746 underwent a 2nd eye examination in the period 2000-2004, while 273 did not (102 patients had died before undergoing the 2nd eye examination). For each patient, the mean (M-FPG) and the coefficient of variation of FPG (CV-FPG) were computed.

RESULTS

By the 2nd eye examination, 124 patients had either developed new retinopathy (79 patients) or progressed to a more severe degree of retinopathy (45 patients). In a multivariable logistic regression analysis, the development/progression of retinopathy was independently predicted by average glycaemia over time, expressed as glycated haemoglobin (odds ratio [OR] 1.82, 95%CI 1.40-2.38 for 1 SD increase) or M-FPG (OR 1.88, 1.47-2.41), but not by CV-FPG. Among other independent variables, HDL-cholesterol was inversely associated with the development/progression of retinopathy.

CONCLUSIONS

These results suggest that in elderly type 2 diabetic patients the magnitude of hyperglycaemia, but not fasting plasma glucose variability, strongly predicts the development/progression of diabetic retinopathy independently of other known risk factors.

Authors+Show Affiliations

Unit of Endocrinology and Metabolic Diseases, University of Verona, Verona Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18571393

Citation

Zoppini, G, et al. "Is Fasting Glucose Variability a Risk Factor for Retinopathy in People With Type 2 Diabetes?" Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 19, no. 5, 2009, pp. 334-9.
Zoppini G, Verlato G, Targher G, et al. Is fasting glucose variability a risk factor for retinopathy in people with type 2 diabetes? Nutr Metab Cardiovasc Dis. 2009;19(5):334-9.
Zoppini, G., Verlato, G., Targher, G., Casati, S., Gusson, E., Biasi, V., ... Muggeo, M. (2009). Is fasting glucose variability a risk factor for retinopathy in people with type 2 diabetes? Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 19(5), pp. 334-9. doi:10.1016/j.numecd.2008.02.007.
Zoppini G, et al. Is Fasting Glucose Variability a Risk Factor for Retinopathy in People With Type 2 Diabetes. Nutr Metab Cardiovasc Dis. 2009;19(5):334-9. PubMed PMID: 18571393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is fasting glucose variability a risk factor for retinopathy in people with type 2 diabetes? AU - Zoppini,G, AU - Verlato,G, AU - Targher,G, AU - Casati,S, AU - Gusson,E, AU - Biasi,V, AU - Perrone,F, AU - Bonora,E, AU - Muggeo,M, Y1 - 2008/06/20/ PY - 2007/10/23/received PY - 2008/01/25/revised PY - 2008/02/26/accepted PY - 2008/6/24/pubmed PY - 2009/8/14/medline PY - 2008/6/24/entrez SP - 334 EP - 9 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 19 IS - 5 N2 - AIMS: Fasting plasma glucose variability strongly predicts the incidence of cardiovascular events in type 2 diabetic patients. We prospectively assessed whether fasting plasma glucose variability predicts the development/progression of retinopathy in a large cohort of type 2 diabetic outpatients. METHODS: In the period 1996-1999, 1019 type 2 diabetic participants (aged 69+/-11 years) in the Verona Diabetes Study underwent at least 3 fasting plasma glucose (FPG) determinations and an eye examination by retinography. Of these, 746 underwent a 2nd eye examination in the period 2000-2004, while 273 did not (102 patients had died before undergoing the 2nd eye examination). For each patient, the mean (M-FPG) and the coefficient of variation of FPG (CV-FPG) were computed. RESULTS: By the 2nd eye examination, 124 patients had either developed new retinopathy (79 patients) or progressed to a more severe degree of retinopathy (45 patients). In a multivariable logistic regression analysis, the development/progression of retinopathy was independently predicted by average glycaemia over time, expressed as glycated haemoglobin (odds ratio [OR] 1.82, 95%CI 1.40-2.38 for 1 SD increase) or M-FPG (OR 1.88, 1.47-2.41), but not by CV-FPG. Among other independent variables, HDL-cholesterol was inversely associated with the development/progression of retinopathy. CONCLUSIONS: These results suggest that in elderly type 2 diabetic patients the magnitude of hyperglycaemia, but not fasting plasma glucose variability, strongly predicts the development/progression of diabetic retinopathy independently of other known risk factors. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/18571393/Is_fasting_glucose_variability_a_risk_factor_for_retinopathy_in_people_with_type_2_diabetes L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(08)00056-2 DB - PRIME DP - Unbound Medicine ER -