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Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia: the Göteborg MCI study.
J Neurol Sci. 2008 Sep 15; 272(1-2):48-59.JN

Abstract

BACKGROUND

Earlier studies have reported that hippocampal atrophy can to some extent predict which patients with mild cognitive impairment (MCI) will subsequently convert to dementia, and that converters have an enhanced rate of hippocampal volume loss.

OBJECTIVE

To further validate the hypothesis that hippocampal atrophy predicts conversion from MCI to dementia, to relate baseline hippocampal volume to different forms of dementia, and to investigate the role of hippocampal side differences and rate of volume loss over time.

PATIENTS

The subjects (N=68) include patients with MCI at baseline and progression to dementia at the two-year follow-up (N=21), stable MCI patients (N=21), and controls (N=26). Among the progressing patients, 13 were diagnosed as having AD.

METHODS

The Göteborg MCI study is a clinically based longitudinal study with biannual clinical assessments. Hippocampal volumetry was performed manually on the MRI investigations at baseline and at the two-year follow-up.

RESULTS

Hippocampal volumetry could predict conversion to dementia in both the AD and the non-AD subgroup of converters. Left hippocampal volume in particular discriminated between converting and stable MCI. Cut off points for individual discrimination were shown to be potentially useful. The converting MCI group had a significantly higher rate of hippocampal volume loss as compared to the stable MCI group.

CONCLUSIONS

In MCI patients, hippocampal volumetry at baseline gives prognostic information about possible development of AD and non-AD dementia. Contrary to earlier studies, we found that left hippocampal volume has the best predictive power. Reliable predictions appear to be possible in many individual cases.

Authors+Show Affiliations

Institute of Neuroscience and Physiology, Göteborg University, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18571674

Citation

Eckerström, C, et al. "Small Baseline Volume of Left Hippocampus Is Associated With Subsequent Conversion of MCI Into Dementia: the Göteborg MCI Study." Journal of the Neurological Sciences, vol. 272, no. 1-2, 2008, pp. 48-59.
Eckerström C, Olsson E, Borga M, et al. Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia: the Göteborg MCI study. J Neurol Sci. 2008;272(1-2):48-59.
Eckerström, C., Olsson, E., Borga, M., Ekholm, S., Ribbelin, S., Rolstad, S., Starck, G., Edman, A., Wallin, A., & Malmgren, H. (2008). Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia: the Göteborg MCI study. Journal of the Neurological Sciences, 272(1-2), 48-59. https://doi.org/10.1016/j.jns.2008.04.024
Eckerström C, et al. Small Baseline Volume of Left Hippocampus Is Associated With Subsequent Conversion of MCI Into Dementia: the Göteborg MCI Study. J Neurol Sci. 2008 Sep 15;272(1-2):48-59. PubMed PMID: 18571674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia: the Göteborg MCI study. AU - Eckerström,C, AU - Olsson,E, AU - Borga,M, AU - Ekholm,S, AU - Ribbelin,S, AU - Rolstad,S, AU - Starck,G, AU - Edman,A, AU - Wallin,A, AU - Malmgren,H, Y1 - 2008/06/20/ PY - 2007/11/26/received PY - 2008/03/17/revised PY - 2008/04/17/accepted PY - 2008/6/24/pubmed PY - 2008/12/19/medline PY - 2008/6/24/entrez SP - 48 EP - 59 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 272 IS - 1-2 N2 - BACKGROUND: Earlier studies have reported that hippocampal atrophy can to some extent predict which patients with mild cognitive impairment (MCI) will subsequently convert to dementia, and that converters have an enhanced rate of hippocampal volume loss. OBJECTIVE: To further validate the hypothesis that hippocampal atrophy predicts conversion from MCI to dementia, to relate baseline hippocampal volume to different forms of dementia, and to investigate the role of hippocampal side differences and rate of volume loss over time. PATIENTS: The subjects (N=68) include patients with MCI at baseline and progression to dementia at the two-year follow-up (N=21), stable MCI patients (N=21), and controls (N=26). Among the progressing patients, 13 were diagnosed as having AD. METHODS: The Göteborg MCI study is a clinically based longitudinal study with biannual clinical assessments. Hippocampal volumetry was performed manually on the MRI investigations at baseline and at the two-year follow-up. RESULTS: Hippocampal volumetry could predict conversion to dementia in both the AD and the non-AD subgroup of converters. Left hippocampal volume in particular discriminated between converting and stable MCI. Cut off points for individual discrimination were shown to be potentially useful. The converting MCI group had a significantly higher rate of hippocampal volume loss as compared to the stable MCI group. CONCLUSIONS: In MCI patients, hippocampal volumetry at baseline gives prognostic information about possible development of AD and non-AD dementia. Contrary to earlier studies, we found that left hippocampal volume has the best predictive power. Reliable predictions appear to be possible in many individual cases. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/18571674/Small_baseline_volume_of_left_hippocampus_is_associated_with_subsequent_conversion_of_MCI_into_dementia:_the_Göteborg_MCI_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(08)00198-6 DB - PRIME DP - Unbound Medicine ER -