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Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004.
Int J Cardiol. 2009 Jun 26; 135(2):156-61.IJ

Abstract

BACKGROUND

Alkaline phosphatase (ALP) is elevated in peripheral arterial disease (PAD). We therefore examined the relationship of PAD with ALP and other liver enzymes in the United States National Health and Nutrition Examination Survey 1999-2004.

METHODS

The analysis included 5995 men and non-pregnant women aged >or=40 years with no missing data in variables of interest. PAD was defined as ankle-brachial blood pressure index (ABI) <0.90 in either leg.

RESULTS

Serum alkaline phosphatase (ALP) level was associated significantly with lower ABI after adjustment for confounding factors (p=0.019). No significant association of ABI with other liver enzymes was found. Serum ALP level increased with increasing age, body mass index, C-reactive protein, monocyte count, serum uric acid, lead, cadmium, and prevalence of hypercholesterolemia, diabetes, smoking, non-alcohol drinking, and cardiovascular diseases after adjusting for age, sex, race/ethnicity, and survey years (p<0.02). The highest quartile of serum ALP was associated with an odds ratio of 1.89 (95% confidence interval [CI]: 1.25-2.85) for PAD after adjustment for confounding factors (p for trend=0.023). In subjects with normal kidney function (glomerular filtration rate >90 ml/min/1.73 m(2)), the odds ratio increased to 4.22 (95% CI 1.45-12.35) (p=0.010).

CONCLUSION

Elevated serum ALP is correlated with PAD, independent of other traditional cardiovascular risk factors.

Authors+Show Affiliations

Department of Medicine, University of Hong Kong, Hong Kong SAR, China. b.cheung@bham.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18572267

Citation

Cheung, Bernard M Y., et al. "Elevated Serum Alkaline Phosphatase and Peripheral Arterial Disease in the United States National Health and Nutrition Examination Survey 1999-2004." International Journal of Cardiology, vol. 135, no. 2, 2009, pp. 156-61.
Cheung BM, Ong KL, Wong LY. Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004. Int J Cardiol. 2009;135(2):156-61.
Cheung, B. M., Ong, K. L., & Wong, L. Y. (2009). Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004. International Journal of Cardiology, 135(2), 156-61. https://doi.org/10.1016/j.ijcard.2008.03.039
Cheung BM, Ong KL, Wong LY. Elevated Serum Alkaline Phosphatase and Peripheral Arterial Disease in the United States National Health and Nutrition Examination Survey 1999-2004. Int J Cardiol. 2009 Jun 26;135(2):156-61. PubMed PMID: 18572267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004. AU - Cheung,Bernard M Y, AU - Ong,Kwok Leung, AU - Wong,Louisa Y F, Y1 - 2008/06/24/ PY - 2007/11/30/received PY - 2008/01/24/revised PY - 2008/03/06/accepted PY - 2008/6/24/pubmed PY - 2009/9/2/medline PY - 2008/6/24/entrez SP - 156 EP - 61 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 135 IS - 2 N2 - BACKGROUND: Alkaline phosphatase (ALP) is elevated in peripheral arterial disease (PAD). We therefore examined the relationship of PAD with ALP and other liver enzymes in the United States National Health and Nutrition Examination Survey 1999-2004. METHODS: The analysis included 5995 men and non-pregnant women aged >or=40 years with no missing data in variables of interest. PAD was defined as ankle-brachial blood pressure index (ABI) <0.90 in either leg. RESULTS: Serum alkaline phosphatase (ALP) level was associated significantly with lower ABI after adjustment for confounding factors (p=0.019). No significant association of ABI with other liver enzymes was found. Serum ALP level increased with increasing age, body mass index, C-reactive protein, monocyte count, serum uric acid, lead, cadmium, and prevalence of hypercholesterolemia, diabetes, smoking, non-alcohol drinking, and cardiovascular diseases after adjusting for age, sex, race/ethnicity, and survey years (p<0.02). The highest quartile of serum ALP was associated with an odds ratio of 1.89 (95% confidence interval [CI]: 1.25-2.85) for PAD after adjustment for confounding factors (p for trend=0.023). In subjects with normal kidney function (glomerular filtration rate >90 ml/min/1.73 m(2)), the odds ratio increased to 4.22 (95% CI 1.45-12.35) (p=0.010). CONCLUSION: Elevated serum ALP is correlated with PAD, independent of other traditional cardiovascular risk factors. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/18572267/Elevated_serum_alkaline_phosphatase_and_peripheral_arterial_disease_in_the_United_States_National_Health_and_Nutrition_Examination_Survey_1999_2004_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(08)00506-8 DB - PRIME DP - Unbound Medicine ER -