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Complete remission of lupus nephritis with rituximab and steroids for induction and rituximab alone for maintenance therapy.
Am J Kidney Dis 2008; 52(2):346-52AJ

Abstract

Lupus nephritis (LN) is a severe and frequent complication of systemic lupus erythematosus. For decades, cyclophosphamide-based regimens have been the gold standard in treating patients with LN. However, cyclophosphamide use is associated with increased morbidity and mortality, and thus alternative treatments are needed. We report 3 cases of severe class IV LN successfully treated with rituximab as an induction, as well as a long-term maintenance, treatment. Complete remission of LN, documented by means of a control kidney biopsy, occurred in all patients and was maintained during follow-up using rituximab as sole maintenance treatment. No severe infectious complications were observed during treatment with rituximab. Our data suggest that rituximab may prove to be an optimal maintenance treatment in patients with severe LN.

Authors+Show Affiliations

Department of Nephrology, Université Paris V-René Descartes, APHP, Hôpital Necker-Enfants Malades, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18572292

Citation

Camous, Laurent, et al. "Complete Remission of Lupus Nephritis With Rituximab and Steroids for Induction and Rituximab Alone for Maintenance Therapy." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 52, no. 2, 2008, pp. 346-52.
Camous L, Melander C, Vallet M, et al. Complete remission of lupus nephritis with rituximab and steroids for induction and rituximab alone for maintenance therapy. Am J Kidney Dis. 2008;52(2):346-52.
Camous, L., Melander, C., Vallet, M., Squalli, T., Knebelmann, B., Noël, L. H., & Fakhouri, F. (2008). Complete remission of lupus nephritis with rituximab and steroids for induction and rituximab alone for maintenance therapy. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 52(2), pp. 346-52. doi:10.1053/j.ajkd.2008.03.036.
Camous L, et al. Complete Remission of Lupus Nephritis With Rituximab and Steroids for Induction and Rituximab Alone for Maintenance Therapy. Am J Kidney Dis. 2008;52(2):346-52. PubMed PMID: 18572292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complete remission of lupus nephritis with rituximab and steroids for induction and rituximab alone for maintenance therapy. AU - Camous,Laurent, AU - Melander,Catherine, AU - Vallet,Marion, AU - Squalli,Tarek, AU - Knebelmann,Bertrand, AU - Noël,Laure-Hélène, AU - Fakhouri,Fadi, Y1 - 2008/06/24/ PY - 2007/11/03/received PY - 2008/03/06/accepted PY - 2008/6/24/pubmed PY - 2008/8/6/medline PY - 2008/6/24/entrez SP - 346 EP - 52 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. VL - 52 IS - 2 N2 - Lupus nephritis (LN) is a severe and frequent complication of systemic lupus erythematosus. For decades, cyclophosphamide-based regimens have been the gold standard in treating patients with LN. However, cyclophosphamide use is associated with increased morbidity and mortality, and thus alternative treatments are needed. We report 3 cases of severe class IV LN successfully treated with rituximab as an induction, as well as a long-term maintenance, treatment. Complete remission of LN, documented by means of a control kidney biopsy, occurred in all patients and was maintained during follow-up using rituximab as sole maintenance treatment. No severe infectious complications were observed during treatment with rituximab. Our data suggest that rituximab may prove to be an optimal maintenance treatment in patients with severe LN. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/18572292/Complete_remission_of_lupus_nephritis_with_rituximab_and_steroids_for_induction_and_rituximab_alone_for_maintenance_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(08)00823-8 DB - PRIME DP - Unbound Medicine ER -