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B-type natriuretic peptides for the diagnosis of congestive heart failure in dyspneic oldest-old patients.
Clin Biochem. 2008 Sep; 41(13):1049-54.CB

Abstract

OBJECTIVES

To evaluate the accuracy of B-type natriuretic peptide (BNP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) for the diagnosis of congestive heart failure (CHF) in dyspneic patients aged >or=85 years admitted to the Emergency Department (ED), and to define threshold values in this oldest-old population.

DESIGN AND METHODS

This study involved 210 oldest-old patients, and 360 patients aged from 65 to 84 years (<85 years), admitted to the ED for dyspnea.

RESULTS

Median BNP and NT-proBNP levels were significantly higher in CHF oldest-old patients (p<0.001). BNP and NT-proBNP threshold values were higher in oldest-old patients (290 and 2800 pg/mL, respectively) compared to that of patients <85 years (270 and 1700 pg/mL, respectively). In a multivariate analysis, both BNP and NT-proBNP were the strongest variables associated with CHF in oldest-old patients. Neither renal function nor gender had impact on the diagnostic utility of the two tests.

CONCLUSION

Both BNP and NT-proBNP could potentially be reliable biomarkers for the diagnosis of CHF in oldest-old patients admitted with acute dyspnea to the ED.

Authors+Show Affiliations

Biochemistry A, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. camille.gobeaux@cch.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18573245

Citation

Chenevier-Gobeaux, Camille, et al. "B-type Natriuretic Peptides for the Diagnosis of Congestive Heart Failure in Dyspneic Oldest-old Patients." Clinical Biochemistry, vol. 41, no. 13, 2008, pp. 1049-54.
Chenevier-Gobeaux C, Delerme S, Allo JC, et al. B-type natriuretic peptides for the diagnosis of congestive heart failure in dyspneic oldest-old patients. Clin Biochem. 2008;41(13):1049-54.
Chenevier-Gobeaux, C., Delerme, S., Allo, J. C., Arthaud, M., Claessens, Y. E., Ekindjian, O. G., Riou, B., & Ray, P. (2008). B-type natriuretic peptides for the diagnosis of congestive heart failure in dyspneic oldest-old patients. Clinical Biochemistry, 41(13), 1049-54. https://doi.org/10.1016/j.clinbiochem.2008.05.012
Chenevier-Gobeaux C, et al. B-type Natriuretic Peptides for the Diagnosis of Congestive Heart Failure in Dyspneic Oldest-old Patients. Clin Biochem. 2008;41(13):1049-54. PubMed PMID: 18573245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - B-type natriuretic peptides for the diagnosis of congestive heart failure in dyspneic oldest-old patients. AU - Chenevier-Gobeaux,Camille, AU - Delerme,Samuel, AU - Allo,Jean-Christophe, AU - Arthaud,Martine, AU - Claessens,Yann-Erick, AU - Ekindjian,Ohvanesse G, AU - Riou,Bruno, AU - Ray,Patrick, Y1 - 2008/06/10/ PY - 2008/02/10/received PY - 2008/05/28/revised PY - 2008/05/29/accepted PY - 2008/6/25/pubmed PY - 2008/10/10/medline PY - 2008/6/25/entrez SP - 1049 EP - 54 JF - Clinical biochemistry JO - Clin Biochem VL - 41 IS - 13 N2 - OBJECTIVES: To evaluate the accuracy of B-type natriuretic peptide (BNP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) for the diagnosis of congestive heart failure (CHF) in dyspneic patients aged >or=85 years admitted to the Emergency Department (ED), and to define threshold values in this oldest-old population. DESIGN AND METHODS: This study involved 210 oldest-old patients, and 360 patients aged from 65 to 84 years (<85 years), admitted to the ED for dyspnea. RESULTS: Median BNP and NT-proBNP levels were significantly higher in CHF oldest-old patients (p<0.001). BNP and NT-proBNP threshold values were higher in oldest-old patients (290 and 2800 pg/mL, respectively) compared to that of patients <85 years (270 and 1700 pg/mL, respectively). In a multivariate analysis, both BNP and NT-proBNP were the strongest variables associated with CHF in oldest-old patients. Neither renal function nor gender had impact on the diagnostic utility of the two tests. CONCLUSION: Both BNP and NT-proBNP could potentially be reliable biomarkers for the diagnosis of CHF in oldest-old patients admitted with acute dyspnea to the ED. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/18573245/B_type_natriuretic_peptides_for_the_diagnosis_of_congestive_heart_failure_in_dyspneic_oldest_old_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(08)00223-3 DB - PRIME DP - Unbound Medicine ER -