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Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibition.
Eur J Pharmacol. 2008 Aug 20; 590(1-3):212-6.EJ

Abstract

Agmatine, a decarboxylation product of arginine, is thought to be an important neuromodulator in the mammalian brain. It is proposed to exert neuroprotective, anxiolytic and antidepressant effects. The receptor-binding profile of agmatine is complex and includes interaction with alpha(2)-adrenergic and imidazoline I(1) receptors. Furthermore, agmatine is an NMDA-receptor antagonist and inhibits nitric oxide synthase. Prepulse inhibition (PPI) of the acoustic startle response is used as a measure of the pre-attentive information processing. PPI is lowered in schizophrenia and this impairment can be mimicked in experimental animals using the psychotomimetic drug phencyclidine (PCP). The aim of the present study was to investigate the effects of agmatine per se on the PPI response and the effects of agmatine pre-treatment on a PCP-induced disruption of PPI. Agmatine administration (10, 20 and 40 mg/kg) did not change the PPI response or the acoustic startle response. However, pre-treatment with agmatine 20 mg/kg, but not agmatine 40 mg/kg, significantly attenuated a PCP (5 mg/kg)-induced disruption of the PPI response. These results emphasize the potential role of agmatine as a neuromodulator and potential target for novel treatments for brain disorders.

Authors+Show Affiliations

Department of Pharmacology, The Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18573247

Citation

Pålsson, Erik, et al. "Agmatine Attenuates the Disruptive Effects of Phencyclidine On Prepulse Inhibition." European Journal of Pharmacology, vol. 590, no. 1-3, 2008, pp. 212-6.
Pålsson E, Fejgin K, Wass C, et al. Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibition. Eur J Pharmacol. 2008;590(1-3):212-6.
Pålsson, E., Fejgin, K., Wass, C., & Klamer, D. (2008). Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibition. European Journal of Pharmacology, 590(1-3), 212-6. https://doi.org/10.1016/j.ejphar.2008.06.022
Pålsson E, et al. Agmatine Attenuates the Disruptive Effects of Phencyclidine On Prepulse Inhibition. Eur J Pharmacol. 2008 Aug 20;590(1-3):212-6. PubMed PMID: 18573247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibition. AU - Pålsson,Erik, AU - Fejgin,Kim, AU - Wass,Caroline, AU - Klamer,Daniel, Y1 - 2008/06/11/ PY - 2008/02/08/received PY - 2008/05/26/revised PY - 2008/06/05/accepted PY - 2008/6/25/pubmed PY - 2008/10/15/medline PY - 2008/6/25/entrez SP - 212 EP - 6 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 590 IS - 1-3 N2 - Agmatine, a decarboxylation product of arginine, is thought to be an important neuromodulator in the mammalian brain. It is proposed to exert neuroprotective, anxiolytic and antidepressant effects. The receptor-binding profile of agmatine is complex and includes interaction with alpha(2)-adrenergic and imidazoline I(1) receptors. Furthermore, agmatine is an NMDA-receptor antagonist and inhibits nitric oxide synthase. Prepulse inhibition (PPI) of the acoustic startle response is used as a measure of the pre-attentive information processing. PPI is lowered in schizophrenia and this impairment can be mimicked in experimental animals using the psychotomimetic drug phencyclidine (PCP). The aim of the present study was to investigate the effects of agmatine per se on the PPI response and the effects of agmatine pre-treatment on a PCP-induced disruption of PPI. Agmatine administration (10, 20 and 40 mg/kg) did not change the PPI response or the acoustic startle response. However, pre-treatment with agmatine 20 mg/kg, but not agmatine 40 mg/kg, significantly attenuated a PCP (5 mg/kg)-induced disruption of the PPI response. These results emphasize the potential role of agmatine as a neuromodulator and potential target for novel treatments for brain disorders. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/18573247/Agmatine_attenuates_the_disruptive_effects_of_phencyclidine_on_prepulse_inhibition_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(08)00645-6 DB - PRIME DP - Unbound Medicine ER -