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Polycystic ovary syndrome in adolescence.
Ann N Y Acad Sci. 2008; 1135:76-84.AN

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive-aged women and is characterized by hyperandrogenemia, menstrual dysfunction, and polycystic ovarian morphology. The hormonal abnormalities inherent in PCOS often begin in adolescence and include hyperinsulinemia and rapid luteinizing hormone (LH) pulse frequency, both of which mediate ovarian and adrenal overproduction of androgens. Although differences exist regarding the diagnostic criteria for PCOS, we believe that hyperandrogenemia is the final common pathway for the development of adolescent PCOS, and we propose a hypothesis to illustrate such. Recognizing and reducing androgen levels in adolescence is critical given their association with the metabolic syndrome (MBS), diabetes, and infertility in adulthood.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Blank SK
The Center for Research in Reproduction, Box 800391, University of Virginia Health System, Charlottesville, VA 22908, USA. sek2h@virginia.edu
Helm KD
No affiliation info available
McCartney CR
No affiliation info available
Marshall JC
No affiliation info available

MeSH

AdolescentAndrogensFemaleHumansHyperinsulinismLuteinizing HormonePolycystic Ovary Syndrome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18574211

Citation

Blank, Susan K., et al. "Polycystic Ovary Syndrome in Adolescence." Annals of the New York Academy of Sciences, vol. 1135, 2008, pp. 76-84.
Blank SK, Helm KD, McCartney CR, et al. Polycystic ovary syndrome in adolescence. Ann N Y Acad Sci. 2008;1135:76-84.
Blank, S. K., Helm, K. D., McCartney, C. R., & Marshall, J. C. (2008). Polycystic ovary syndrome in adolescence. Annals of the New York Academy of Sciences, 1135, 76-84. https://doi.org/10.1196/annals.1429.005
Blank SK, et al. Polycystic Ovary Syndrome in Adolescence. Ann N Y Acad Sci. 2008;1135:76-84. PubMed PMID: 18574211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polycystic ovary syndrome in adolescence. AU - Blank,Susan K, AU - Helm,Kristin D, AU - McCartney,Christopher R, AU - Marshall,John C, PY - 2008/6/25/pubmed PY - 2008/10/1/medline PY - 2008/6/25/entrez SP - 76 EP - 84 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1135 N2 - Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive-aged women and is characterized by hyperandrogenemia, menstrual dysfunction, and polycystic ovarian morphology. The hormonal abnormalities inherent in PCOS often begin in adolescence and include hyperinsulinemia and rapid luteinizing hormone (LH) pulse frequency, both of which mediate ovarian and adrenal overproduction of androgens. Although differences exist regarding the diagnostic criteria for PCOS, we believe that hyperandrogenemia is the final common pathway for the development of adolescent PCOS, and we propose a hypothesis to illustrate such. Recognizing and reducing androgen levels in adolescence is critical given their association with the metabolic syndrome (MBS), diabetes, and infertility in adulthood. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/18574211/Polycystic_ovary_syndrome_in_adolescence_ DB - PRIME DP - Unbound Medicine ER -