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Ibuprofen versus acetaminophen for the relief of perineal pain after childbirth: a randomized controlled trial.

Abstract

OBJECTIVES

To evaluate efficacy of ibuprofen compared with acetaminophen for relief of perineal pain after childbirth, side effects of ibuprofen compared with acetaminophen and patient satisfaction in treatment between the 2 groups.

MATERIAL AND METHOD

A total of 210 women who gave birth by spontaneous vaginal delivery with mediolateral episiotomy between June 2006 and November 2006 were randomly assigned to receive either ibuprofen (400 mg) (n = 106) or acetaminophen (1000 mg) (n = 104), both given orally when suturing was completed. Pain ratings were recorded before the treatment and at 1, 2, 3 and 4 hours after the treatment on a 10-cm visual analogue scale. Side effects and patient satisfaction were assessed at 24 hours.

RESULTS

Pain in the ibuprofen group was considerably more reduced than the acetaminophen group at 1 hour of treatment (mean pain rating 2.18 vs. 2.88, respectively; p < 0.003). Even though, at 2, 3 and 4 hours of treatment ibuprofen seemed to give more reliefof pain than acetaminophen, they did not reach statistically significant differences (mean pain rating; at 2 hour: 1.59 vs. 1.97, p = 0.093; at 3 hour: 1.08 vs. 1.31, p = 0.183; and at 4 hour: 0.69 vs. 0.85, p = 0.169; respectively). There were no side effects and no significant differences in overall patient satisfaction between the two groups.

CONCLUSION

Ibuprofen was consistently better than acetaminophen at 1 hour after treatment for relief of perineal pain after childbirth without any side effects. After 2 hours, ibuprofen and acetaminophen had similar analgesic properties.

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Authors+Show Affiliations

,

Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Source

MeSH

Acetaminophen
Adult
Analgesics, Non-Narcotic
Anti-Inflammatory Agents, Non-Steroidal
Episiotomy
Female
Humans
Ibuprofen
Neuralgia
Pain Measurement
Pain, Postoperative
Patient Satisfaction
Pregnancy
Time Factors

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18575278

Citation

Kamondetdecha, Rungtiwa, and Yuen Tannirandorn. "Ibuprofen Versus Acetaminophen for the Relief of Perineal Pain After Childbirth: a Randomized Controlled Trial." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 91, no. 3, 2008, pp. 282-6.
Kamondetdecha R, Tannirandorn Y. Ibuprofen versus acetaminophen for the relief of perineal pain after childbirth: a randomized controlled trial. J Med Assoc Thai. 2008;91(3):282-6.
Kamondetdecha, R., & Tannirandorn, Y. (2008). Ibuprofen versus acetaminophen for the relief of perineal pain after childbirth: a randomized controlled trial. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 91(3), pp. 282-6.
Kamondetdecha R, Tannirandorn Y. Ibuprofen Versus Acetaminophen for the Relief of Perineal Pain After Childbirth: a Randomized Controlled Trial. J Med Assoc Thai. 2008;91(3):282-6. PubMed PMID: 18575278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ibuprofen versus acetaminophen for the relief of perineal pain after childbirth: a randomized controlled trial. AU - Kamondetdecha,Rungtiwa, AU - Tannirandorn,Yuen, PY - 2008/6/26/pubmed PY - 2008/8/16/medline PY - 2008/6/26/entrez SP - 282 EP - 6 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 91 IS - 3 N2 - OBJECTIVES: To evaluate efficacy of ibuprofen compared with acetaminophen for relief of perineal pain after childbirth, side effects of ibuprofen compared with acetaminophen and patient satisfaction in treatment between the 2 groups. MATERIAL AND METHOD: A total of 210 women who gave birth by spontaneous vaginal delivery with mediolateral episiotomy between June 2006 and November 2006 were randomly assigned to receive either ibuprofen (400 mg) (n = 106) or acetaminophen (1000 mg) (n = 104), both given orally when suturing was completed. Pain ratings were recorded before the treatment and at 1, 2, 3 and 4 hours after the treatment on a 10-cm visual analogue scale. Side effects and patient satisfaction were assessed at 24 hours. RESULTS: Pain in the ibuprofen group was considerably more reduced than the acetaminophen group at 1 hour of treatment (mean pain rating 2.18 vs. 2.88, respectively; p < 0.003). Even though, at 2, 3 and 4 hours of treatment ibuprofen seemed to give more reliefof pain than acetaminophen, they did not reach statistically significant differences (mean pain rating; at 2 hour: 1.59 vs. 1.97, p = 0.093; at 3 hour: 1.08 vs. 1.31, p = 0.183; and at 4 hour: 0.69 vs. 0.85, p = 0.169; respectively). There were no side effects and no significant differences in overall patient satisfaction between the two groups. CONCLUSION: Ibuprofen was consistently better than acetaminophen at 1 hour after treatment for relief of perineal pain after childbirth without any side effects. After 2 hours, ibuprofen and acetaminophen had similar analgesic properties. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/18575278/Ibuprofen_versus_acetaminophen_for_the_relief_of_perineal_pain_after_childbirth:_a_randomized_controlled_trial_ L2 - https://medlineplus.gov/painrelievers.html DB - PRIME DP - Unbound Medicine ER -