Ibuprofen versus acetaminophen for the relief of perineal pain after childbirth: a randomized controlled trial.J Med Assoc Thai 2008; 91(3):282-6JM
To evaluate efficacy of ibuprofen compared with acetaminophen for relief of perineal pain after childbirth, side effects of ibuprofen compared with acetaminophen and patient satisfaction in treatment between the 2 groups.
MATERIAL AND METHOD
A total of 210 women who gave birth by spontaneous vaginal delivery with mediolateral episiotomy between June 2006 and November 2006 were randomly assigned to receive either ibuprofen (400 mg) (n = 106) or acetaminophen (1000 mg) (n = 104), both given orally when suturing was completed. Pain ratings were recorded before the treatment and at 1, 2, 3 and 4 hours after the treatment on a 10-cm visual analogue scale. Side effects and patient satisfaction were assessed at 24 hours.
Pain in the ibuprofen group was considerably more reduced than the acetaminophen group at 1 hour of treatment (mean pain rating 2.18 vs. 2.88, respectively; p < 0.003). Even though, at 2, 3 and 4 hours of treatment ibuprofen seemed to give more reliefof pain than acetaminophen, they did not reach statistically significant differences (mean pain rating; at 2 hour: 1.59 vs. 1.97, p = 0.093; at 3 hour: 1.08 vs. 1.31, p = 0.183; and at 4 hour: 0.69 vs. 0.85, p = 0.169; respectively). There were no side effects and no significant differences in overall patient satisfaction between the two groups.
Ibuprofen was consistently better than acetaminophen at 1 hour after treatment for relief of perineal pain after childbirth without any side effects. After 2 hours, ibuprofen and acetaminophen had similar analgesic properties.