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[Toxicity of Caowu on in vitro cultured rat embryos].
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 May; 39(3):441-4.SD

Abstract

OBJECTIVE

To study the developmental toxicity of Caowu and its mechanism on rat embryos.

METHODS

Whole embryo culture was applied to test the effects of Caowu on rat embryos during the critical period of organogenesis. All embryos isolated on gestational day 9.5 were exposed to different concentrations of Caowu. The growth and differentiation of the embryos at the end of the 48 h culture period were observed.

RESULTS

The embryonic growth and development were adversely affected by Caowu at the concentration of 2.5 mg/mL, which were represented as reduced yolk sac diameters, decreased number of somites, and lower morphological scores. With the increase of the concentrations of Caowu, more severe teratogenic effects appeared, including cardiac defect (undivided cardiac tube and inflated pericardial cavity), irregular somites, and brain malformation such as narrow brain vesicles.

CONCLUSION

Caowu has direct embryotoxic effects on rats during the organogenesis period. We suggest that pregnant women in the first trimester use Caowu with cautions before a conclusion has been made.

Authors+Show Affiliations

National Chengdu Center for Safety Evaluation of Drugs, West China Hospital, Sichuan University, Chengdu 610041, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18575336

Citation

Xiao, Kai, et al. "[Toxicity of Caowu On in Vitro Cultured Rat Embryos]." Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition, vol. 39, no. 3, 2008, pp. 441-4.
Xiao K, Yan GY, Wang L, et al. [Toxicity of Caowu on in vitro cultured rat embryos]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39(3):441-4.
Xiao, K., Yan, G. Y., Wang, L., Liu, Y. Q., Peng, C., Duan, J. C., Fu, Z. T., & Li, H. X. (2008). [Toxicity of Caowu on in vitro cultured rat embryos]. Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition, 39(3), 441-4.
Xiao K, et al. [Toxicity of Caowu On in Vitro Cultured Rat Embryos]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39(3):441-4. PubMed PMID: 18575336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Toxicity of Caowu on in vitro cultured rat embryos]. AU - Xiao,Kai, AU - Yan,Guang-Yan, AU - Wang,Li, AU - Liu,Yu-Qing, AU - Peng,Cheng, AU - Duan,Jia-Chuan, AU - Fu,Zheng-Tao, AU - Li,Hong-Xia, PY - 2008/6/26/pubmed PY - 2009/2/10/medline PY - 2008/6/26/entrez SP - 441 EP - 4 JF - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition JO - Sichuan Da Xue Xue Bao Yi Xue Ban VL - 39 IS - 3 N2 - OBJECTIVE: To study the developmental toxicity of Caowu and its mechanism on rat embryos. METHODS: Whole embryo culture was applied to test the effects of Caowu on rat embryos during the critical period of organogenesis. All embryos isolated on gestational day 9.5 were exposed to different concentrations of Caowu. The growth and differentiation of the embryos at the end of the 48 h culture period were observed. RESULTS: The embryonic growth and development were adversely affected by Caowu at the concentration of 2.5 mg/mL, which were represented as reduced yolk sac diameters, decreased number of somites, and lower morphological scores. With the increase of the concentrations of Caowu, more severe teratogenic effects appeared, including cardiac defect (undivided cardiac tube and inflated pericardial cavity), irregular somites, and brain malformation such as narrow brain vesicles. CONCLUSION: Caowu has direct embryotoxic effects on rats during the organogenesis period. We suggest that pregnant women in the first trimester use Caowu with cautions before a conclusion has been made. SN - 1672-173X UR - https://www.unboundmedicine.com/medline/citation/18575336/[Toxicity_of_Caowu_on_in_vitro_cultured_rat_embryos]_ DB - PRIME DP - Unbound Medicine ER -