Tags

Type your tag names separated by a space and hit enter

Patterns of neuropsychological impairment in MCI patients with small subcortical infarcts or hippocampal atrophy.
J Int Neuropsychol Soc. 2008 Jul; 14(4):611-9.JI

Abstract

We investigated whether MCI patients with hippocampal atrophy or multiple subcortical infarcts demonstrate neuropsychological patterns and markers considered typical of Alzheimer's disease (AD) and of vascular dementia (VD), respectively. An extensive neuropsychological battery, including tests of memory, visual-spatial and executive functions, language, attention, praxis and psychomotor speed, was administered to 36 mild cognitive impairment (MCI) patients with hippocampal atrophy and 41 MCI patients with multiple subcortical infarcts. Both groups of MCI patients were very mildly impaired and well matched in terms of MMSE scores. A clear, disproportionately severe, episodic memory disorder was observed in MCI patients with hippocampal atrophy. A less specific neuropsychological profile, consisting of impairment on an Action Naming task that is sensitive to frontal lobe lesions, was observed in MCI patients with multiple subcortical infarcts. In MCI patients, a disproportionately severe episodic memory impairment strongly points to an Alzheimer's type brain pathology, whereas the prevalence of executive deficits and other frontal lobe symptoms are a much weaker diagnostic marker of small vessel subcortical disease.

Authors+Show Affiliations

Neuropsychology Service of the UCSC/Policlinico Gemelli, Catholic University of Rome, Rome, Italy. gainotti@rm.unicatt.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18577290

Citation

Gainotti, Guido, et al. "Patterns of Neuropsychological Impairment in MCI Patients With Small Subcortical Infarcts or Hippocampal Atrophy." Journal of the International Neuropsychological Society : JINS, vol. 14, no. 4, 2008, pp. 611-9.
Gainotti G, Ferraccioli M, Vita MG, et al. Patterns of neuropsychological impairment in MCI patients with small subcortical infarcts or hippocampal atrophy. J Int Neuropsychol Soc. 2008;14(4):611-9.
Gainotti, G., Ferraccioli, M., Vita, M. G., & Marra, C. (2008). Patterns of neuropsychological impairment in MCI patients with small subcortical infarcts or hippocampal atrophy. Journal of the International Neuropsychological Society : JINS, 14(4), 611-9. https://doi.org/10.1017/S1355617708080831
Gainotti G, et al. Patterns of Neuropsychological Impairment in MCI Patients With Small Subcortical Infarcts or Hippocampal Atrophy. J Int Neuropsychol Soc. 2008;14(4):611-9. PubMed PMID: 18577290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterns of neuropsychological impairment in MCI patients with small subcortical infarcts or hippocampal atrophy. AU - Gainotti,Guido, AU - Ferraccioli,Monica, AU - Vita,Maria Gabriella, AU - Marra,Camillo, PY - 2008/6/26/pubmed PY - 2009/1/16/medline PY - 2008/6/26/entrez SP - 611 EP - 9 JF - Journal of the International Neuropsychological Society : JINS JO - J Int Neuropsychol Soc VL - 14 IS - 4 N2 - We investigated whether MCI patients with hippocampal atrophy or multiple subcortical infarcts demonstrate neuropsychological patterns and markers considered typical of Alzheimer's disease (AD) and of vascular dementia (VD), respectively. An extensive neuropsychological battery, including tests of memory, visual-spatial and executive functions, language, attention, praxis and psychomotor speed, was administered to 36 mild cognitive impairment (MCI) patients with hippocampal atrophy and 41 MCI patients with multiple subcortical infarcts. Both groups of MCI patients were very mildly impaired and well matched in terms of MMSE scores. A clear, disproportionately severe, episodic memory disorder was observed in MCI patients with hippocampal atrophy. A less specific neuropsychological profile, consisting of impairment on an Action Naming task that is sensitive to frontal lobe lesions, was observed in MCI patients with multiple subcortical infarcts. In MCI patients, a disproportionately severe episodic memory impairment strongly points to an Alzheimer's type brain pathology, whereas the prevalence of executive deficits and other frontal lobe symptoms are a much weaker diagnostic marker of small vessel subcortical disease. SN - 1469-7661 UR - https://www.unboundmedicine.com/medline/citation/18577290/Patterns_of_neuropsychological_impairment_in_MCI_patients_with_small_subcortical_infarcts_or_hippocampal_atrophy_ L2 - https://www.cambridge.org/core/product/identifier/S1355617708080831/type/journal_article DB - PRIME DP - Unbound Medicine ER -