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Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra.
Exp Neurol. 2008 Aug; 212(2):532-7.EN

Abstract

Ghrelin, a stomach-derived hormone which induces growth hormone release and promotes positive energy balance, has been reported to inhibit cell apoptosis in endotheliocytes, osteoblasts and cardiocytes. Recent evidence has shown that ghrelin can also inhibit neuronal apoptosis of the hypothalamus and the hippocampus. However, little is known about the effects of ghrelin on the substantia nigra pars compacta (SNpc) neurons in which ghrelin's receptor, growth hormone secretagogue receptor (GHSR)-1a, is highly expressed. In the present study, we investigated whether ghrelin could protect nigral dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice. We observed that ghrelin, acting through GHS-R 1a, inhibited MPTP-induced dopaminergic neuronal loss in the SNpc as well as dopamine depletion in the striatum. Ghrelin could also reverse the down-regulated the expression of Bcl-2, up-regulated the expression of Bax, and caspase-3 activation caused by MPTP. This study demonstrated that ghrelin might be a potential protector of dopaminergic neurons in a therapeutic strategy for Parkinson's disease.

Authors+Show Affiliations

State Key Disciplines: Physiology (in incubation), Department of Physiology, Medical College of Qingdao University, Qingdao, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18577498

Citation

Jiang, Hong, et al. "Ghrelin Antagonizes MPTP-induced Neurotoxicity to the Dopaminergic Neurons in Mouse Substantia Nigra." Experimental Neurology, vol. 212, no. 2, 2008, pp. 532-7.
Jiang H, Li LJ, Wang J, et al. Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. Exp Neurol. 2008;212(2):532-7.
Jiang, H., Li, L. J., Wang, J., & Xie, J. X. (2008). Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. Experimental Neurology, 212(2), 532-7. https://doi.org/10.1016/j.expneurol.2008.05.006
Jiang H, et al. Ghrelin Antagonizes MPTP-induced Neurotoxicity to the Dopaminergic Neurons in Mouse Substantia Nigra. Exp Neurol. 2008;212(2):532-7. PubMed PMID: 18577498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. AU - Jiang,Hong, AU - Li,Lin-Jing, AU - Wang,Jun, AU - Xie,Jun-Xia, Y1 - 2008/05/20/ PY - 2007/12/14/received PY - 2008/05/01/revised PY - 2008/05/02/accepted PY - 2008/6/26/pubmed PY - 2008/9/3/medline PY - 2008/6/26/entrez SP - 532 EP - 7 JF - Experimental neurology JO - Exp Neurol VL - 212 IS - 2 N2 - Ghrelin, a stomach-derived hormone which induces growth hormone release and promotes positive energy balance, has been reported to inhibit cell apoptosis in endotheliocytes, osteoblasts and cardiocytes. Recent evidence has shown that ghrelin can also inhibit neuronal apoptosis of the hypothalamus and the hippocampus. However, little is known about the effects of ghrelin on the substantia nigra pars compacta (SNpc) neurons in which ghrelin's receptor, growth hormone secretagogue receptor (GHSR)-1a, is highly expressed. In the present study, we investigated whether ghrelin could protect nigral dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice. We observed that ghrelin, acting through GHS-R 1a, inhibited MPTP-induced dopaminergic neuronal loss in the SNpc as well as dopamine depletion in the striatum. Ghrelin could also reverse the down-regulated the expression of Bcl-2, up-regulated the expression of Bax, and caspase-3 activation caused by MPTP. This study demonstrated that ghrelin might be a potential protector of dopaminergic neurons in a therapeutic strategy for Parkinson's disease. SN - 1090-2430 UR - https://www.unboundmedicine.com/medline/citation/18577498/Ghrelin_antagonizes_MPTP_induced_neurotoxicity_to_the_dopaminergic_neurons_in_mouse_substantia_nigra_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(08)00210-0 DB - PRIME DP - Unbound Medicine ER -