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[Relationship between B-type natriuretic peptide plasma level and left ventricular function in patients with chronic kidney disease on different type of treatment].
Acta Med Croatica. 2008; 62 Suppl 1:7-11.AM

Abstract

AIM

To evaluate relationship between echocardiography finding of LV mass and function and B-type natriuretic peptide (BNP) plasma level in patients with chronic kidney disease on different type of treatment.

METHODS

We performed comparative examine on a parallel groups of kidney patients with no clinical signs of heart failure: 25 patients with chronic kidney disease (CKD, creatinine klirens < 60 ml/min), 25 patients on peritoneal dialysis (PD), 34 patients on hemodialysis (HD) and 22 renal transplant patients. Each patient underwent echocardiography investigations and measured plasma level B-type natriuretic peptide.

RESULTS

It was determined that hemodialysis patients had higher value of left ventricular mass index (LVMI). The incidence of left ventricular hypertrophy (LVH) progressive increased from CKD patients to HD patients (78.6% vs. 88.9%), as well as a plasma level of B-type natriuretic peptide (174.2 vs. 1020.2 pg/ml). There was a significant positive correlation between LVMI and BNP plasma level in CKD (p = 0.008) and HD patients (p = 0.001), as well as significant negative correlation between BNP plasma level and LV diastolicfunction in CKD patients (p = 0.002).

CONCLUSION

Plasma BNP concentration was elevated in renal dysfunction. Plasma BNP levels and the incidence of LVH were significantly grater in HD patients than in other renal patients. Significant positive correlation between plasma BNP level and LVMI suggested simultaneous influence of renal dysfunction and plasma BNP level on development of LV dysfunction.

Authors+Show Affiliations

Klinika za nefrologiju, Klinicki Centar Univerziteta Sarajevo, Bosna i Hercegovina. rasicnef@bih.net.baNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

hrv

PubMed ID

18578326

Citation

Rasić, Senija, et al. "[Relationship Between B-type Natriuretic Peptide Plasma Level and Left Ventricular Function in Patients With Chronic Kidney Disease On Different Type of Treatment]." Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti, vol. 62 Suppl 1, 2008, pp. 7-11.
Rasić S, Hadzovic-Dzuvo A, Rebić D, et al. [Relationship between B-type natriuretic peptide plasma level and left ventricular function in patients with chronic kidney disease on different type of treatment]. Acta Med Croatica. 2008;62 Suppl 1:7-11.
Rasić, S., Hadzovic-Dzuvo, A., Rebić, D., Dzemidzić, J., Bilal, F., & Mataradzija, A. (2008). [Relationship between B-type natriuretic peptide plasma level and left ventricular function in patients with chronic kidney disease on different type of treatment]. Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti, 62 Suppl 1, 7-11.
Rasić S, et al. [Relationship Between B-type Natriuretic Peptide Plasma Level and Left Ventricular Function in Patients With Chronic Kidney Disease On Different Type of Treatment]. Acta Med Croatica. 2008;62 Suppl 1:7-11. PubMed PMID: 18578326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between B-type natriuretic peptide plasma level and left ventricular function in patients with chronic kidney disease on different type of treatment]. AU - Rasić,Senija, AU - Hadzovic-Dzuvo,Almira, AU - Rebić,Damir, AU - Dzemidzić,Jasminka, AU - Bilal,Fatima, AU - Mataradzija,Amra, PY - 2008/6/27/pubmed PY - 2008/9/16/medline PY - 2008/6/27/entrez SP - 7 EP - 11 JF - Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti JO - Acta Med Croatica VL - 62 Suppl 1 N2 - AIM: To evaluate relationship between echocardiography finding of LV mass and function and B-type natriuretic peptide (BNP) plasma level in patients with chronic kidney disease on different type of treatment. METHODS: We performed comparative examine on a parallel groups of kidney patients with no clinical signs of heart failure: 25 patients with chronic kidney disease (CKD, creatinine klirens < 60 ml/min), 25 patients on peritoneal dialysis (PD), 34 patients on hemodialysis (HD) and 22 renal transplant patients. Each patient underwent echocardiography investigations and measured plasma level B-type natriuretic peptide. RESULTS: It was determined that hemodialysis patients had higher value of left ventricular mass index (LVMI). The incidence of left ventricular hypertrophy (LVH) progressive increased from CKD patients to HD patients (78.6% vs. 88.9%), as well as a plasma level of B-type natriuretic peptide (174.2 vs. 1020.2 pg/ml). There was a significant positive correlation between LVMI and BNP plasma level in CKD (p = 0.008) and HD patients (p = 0.001), as well as significant negative correlation between BNP plasma level and LV diastolicfunction in CKD patients (p = 0.002). CONCLUSION: Plasma BNP concentration was elevated in renal dysfunction. Plasma BNP levels and the incidence of LVH were significantly grater in HD patients than in other renal patients. Significant positive correlation between plasma BNP level and LVMI suggested simultaneous influence of renal dysfunction and plasma BNP level on development of LV dysfunction. SN - 1330-0164 UR - https://www.unboundmedicine.com/medline/citation/18578326/[Relationship_between_B_type_natriuretic_peptide_plasma_level_and_left_ventricular_function_in_patients_with_chronic_kidney_disease_on_different_type_of_treatment]_ L2 - http://www.diseaseinfosearch.org/result/3996 DB - PRIME DP - Unbound Medicine ER -