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Clinical predictors of recurrent venous thromboembolism: a single institute experience in Korea.
Thromb Res 2009; 123(3):436-43TR

Abstract

INTRODUCTION

Racial disparities in incidence rate as well as risk factors for venous thromboembolism (VTE) exist between Asian and Western populations. Moreover, predictors for recurrent VTE were not identified in Asians. Thus, this study was undertaken to investigate risk factors for recurrent VTE events in Korean people.

MATERIALS AND METHODS

Three hundred-three patients newly diagnosed as VTE were enrolled from Seoul National University Hospital. Recurrence rate based on risk factors for VTE were investigated. Cumulative incidence of recurrent VTE was calculated by the Kaplan and Meier method. Independent predictors for VTE were determined using Cox proportional hazards model.

RESULTS

After a median follow-up of 44 months, 24 (8%) of 303 patients relapsed for a total observation time of 1,217 patient-year. Cumulative incidences of recurrent VTE were 3% at 1 year, 10% at 5 years, and 18% at 8 years. Independent predictors for recurrent VTE were presence of residual thrombosis (hazard ratio [HR]=3.1, 95% confidence interval [CI] 1.0-9.3; p=0.044), antiphospholipid syndrome (APS) (HR=4.3, 95% CI 1.0-19.0; p=0.052), and age 50 years or younger (HR=2.5, 95% CI 1.0-6.6; p=0.053) by multivariate analysis. Residual thrombosis and APS remained predictive of recurrence by the anticoagulation-period stratified analysis.

CONCLUSIONS

In contrast to Western populations, Korean patients with VTE had the lower recurrent rate. Extended anticoagulation is necessary for Korean patients with residual thrombosis or APS.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18579181

Citation

Kim, Tae Min, et al. "Clinical Predictors of Recurrent Venous Thromboembolism: a Single Institute Experience in Korea." Thrombosis Research, vol. 123, no. 3, 2009, pp. 436-43.
Kim TM, Kim JS, Han SW, et al. Clinical predictors of recurrent venous thromboembolism: a single institute experience in Korea. Thromb Res. 2009;123(3):436-43.
Kim, T. M., Kim, J. S., Han, S. W., Hong, Y. S., Kim, I., Ha, J., ... Yoon, S. S. (2009). Clinical predictors of recurrent venous thromboembolism: a single institute experience in Korea. Thrombosis Research, 123(3), pp. 436-43. doi:10.1016/j.thromres.2008.05.009.
Kim TM, et al. Clinical Predictors of Recurrent Venous Thromboembolism: a Single Institute Experience in Korea. Thromb Res. 2009;123(3):436-43. PubMed PMID: 18579181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical predictors of recurrent venous thromboembolism: a single institute experience in Korea. AU - Kim,Tae Min, AU - Kim,Jin Soo, AU - Han,Sae Won, AU - Hong,Yong Sang, AU - Kim,Inho, AU - Ha,Jongwon, AU - Kim,Sang Joon, AU - Chung,Jin Wook, AU - Park,Jae Hyung, AU - Lee,Dongsoon, AU - Park,Seonyang, AU - Kim,Byoung Kook, AU - Kim,Noe Kyeong, AU - Yoon,Sung-Soo, Y1 - 2008/06/24/ PY - 2007/11/02/received PY - 2008/03/20/revised PY - 2008/05/09/accepted PY - 2008/6/27/pubmed PY - 2009/4/3/medline PY - 2008/6/27/entrez SP - 436 EP - 43 JF - Thrombosis research JO - Thromb. Res. VL - 123 IS - 3 N2 - INTRODUCTION: Racial disparities in incidence rate as well as risk factors for venous thromboembolism (VTE) exist between Asian and Western populations. Moreover, predictors for recurrent VTE were not identified in Asians. Thus, this study was undertaken to investigate risk factors for recurrent VTE events in Korean people. MATERIALS AND METHODS: Three hundred-three patients newly diagnosed as VTE were enrolled from Seoul National University Hospital. Recurrence rate based on risk factors for VTE were investigated. Cumulative incidence of recurrent VTE was calculated by the Kaplan and Meier method. Independent predictors for VTE were determined using Cox proportional hazards model. RESULTS: After a median follow-up of 44 months, 24 (8%) of 303 patients relapsed for a total observation time of 1,217 patient-year. Cumulative incidences of recurrent VTE were 3% at 1 year, 10% at 5 years, and 18% at 8 years. Independent predictors for recurrent VTE were presence of residual thrombosis (hazard ratio [HR]=3.1, 95% confidence interval [CI] 1.0-9.3; p=0.044), antiphospholipid syndrome (APS) (HR=4.3, 95% CI 1.0-19.0; p=0.052), and age 50 years or younger (HR=2.5, 95% CI 1.0-6.6; p=0.053) by multivariate analysis. Residual thrombosis and APS remained predictive of recurrence by the anticoagulation-period stratified analysis. CONCLUSIONS: In contrast to Western populations, Korean patients with VTE had the lower recurrent rate. Extended anticoagulation is necessary for Korean patients with residual thrombosis or APS. SN - 0049-3848 UR - https://www.unboundmedicine.com/medline/citation/18579181/Clinical_predictors_of_recurrent_venous_thromboembolism:_a_single_institute_experience_in_Korea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(08)00197-7 DB - PRIME DP - Unbound Medicine ER -