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Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds.
Cancer Lett. 2008 Oct 08; 269(2):305-14.CL

Abstract

Allium vegetables, such as garlic, have been used for medicinal purposes throughout the recorded history. The known health benefits of Allium vegetables constituents include cardiovascular effects, improvement of the immune function, lowering of blood glucose level, radioprotection, protection against microbial infections, and anti-cancer effects. Initial evidence for the anti-cancer effect of Allium vegetables was provided by population-based case-control studies. Subsequent laboratory studies showed that the Allium vegetable constituents, such as diallyl disulfide, S-allylcysteine, and ajoene can not only offer protection against chemically induced cancer in animal models by altering carcinogen metabolism, but also suppress growth of cancer cells in culture and in vivo by causing cell cycle arrest and apoptosis induction. Suppression of angiogenesis and experimental metastasis by Allium constituents has also been reported. Defining the mechanism by which sulfur compounds derived from Allium vegetables inhibit cancer cell growth has been the topic of intense research in the last two decades. Some Allium vegetable constituents have also entered clinical trials to assess their safety and anti-cancer efficacy. This article summarizes preclinical and limited clinical data to warrant further clinical evaluation of Allium vegetable constituents for prevention and therapy of human cancers.

Authors+Show Affiliations

Department of Pharmacology and Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

18579286

Citation

Powolny, Anna A., and Shivendra V. Singh. "Multitargeted Prevention and Therapy of Cancer By Diallyl Trisulfide and Related Allium Vegetable-derived Organosulfur Compounds." Cancer Letters, vol. 269, no. 2, 2008, pp. 305-14.
Powolny AA, Singh SV. Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds. Cancer Lett. 2008;269(2):305-14.
Powolny, A. A., & Singh, S. V. (2008). Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds. Cancer Letters, 269(2), 305-14. https://doi.org/10.1016/j.canlet.2008.05.027
Powolny AA, Singh SV. Multitargeted Prevention and Therapy of Cancer By Diallyl Trisulfide and Related Allium Vegetable-derived Organosulfur Compounds. Cancer Lett. 2008 Oct 8;269(2):305-14. PubMed PMID: 18579286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds. AU - Powolny,Anna A, AU - Singh,Shivendra V, Y1 - 2008/06/24/ PY - 2008/01/08/received PY - 2008/01/08/revised PY - 2008/05/14/accepted PY - 2008/6/27/pubmed PY - 2008/10/15/medline PY - 2008/6/27/entrez SP - 305 EP - 14 JF - Cancer letters JO - Cancer Lett VL - 269 IS - 2 N2 - Allium vegetables, such as garlic, have been used for medicinal purposes throughout the recorded history. The known health benefits of Allium vegetables constituents include cardiovascular effects, improvement of the immune function, lowering of blood glucose level, radioprotection, protection against microbial infections, and anti-cancer effects. Initial evidence for the anti-cancer effect of Allium vegetables was provided by population-based case-control studies. Subsequent laboratory studies showed that the Allium vegetable constituents, such as diallyl disulfide, S-allylcysteine, and ajoene can not only offer protection against chemically induced cancer in animal models by altering carcinogen metabolism, but also suppress growth of cancer cells in culture and in vivo by causing cell cycle arrest and apoptosis induction. Suppression of angiogenesis and experimental metastasis by Allium constituents has also been reported. Defining the mechanism by which sulfur compounds derived from Allium vegetables inhibit cancer cell growth has been the topic of intense research in the last two decades. Some Allium vegetable constituents have also entered clinical trials to assess their safety and anti-cancer efficacy. This article summarizes preclinical and limited clinical data to warrant further clinical evaluation of Allium vegetable constituents for prevention and therapy of human cancers. SN - 1872-7980 UR - https://www.unboundmedicine.com/medline/citation/18579286/Multitargeted_prevention_and_therapy_of_cancer_by_diallyl_trisulfide_and_related_Allium_vegetable_derived_organosulfur_compounds_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(08)00397-2 DB - PRIME DP - Unbound Medicine ER -