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Involvement of the serotonin system in L-dopa-induced dyskinesias.
Parkinsonism Relat Disord. 2008; 14 Suppl 2:S154-8.PR

Abstract

The ability of L-dopa to relieve the motor impairments in Parkinson's disease patients declines over time, and side-effects, such as dyskinesias, appear--limiting the use of the drug in the advanced stage of the disease. Serotonergic neurons are able to convert L-dopa to dopamine and to store this neurotransmitter in synaptic vesicles. This peculiarity might be very important in the advanced disease, when most of the dopaminergic neurons have degenerated. Indeed, an increasing body of evidence points to dopamine released as a false neurotransmitter from the serotonin terminals as the main pre-synaptic determinant of L-dopa-induced dyskinesias in animal models of Parkinson's disease. These findings make the serotonin system an intriguing target for anti-dyskinetic therapies.

Authors+Show Affiliations

Neurobiology Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden. Manolo.Carta@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18579429

Citation

Carta, Manolo, et al. "Involvement of the Serotonin System in L-dopa-induced Dyskinesias." Parkinsonism & Related Disorders, vol. 14 Suppl 2, 2008, pp. S154-8.
Carta M, Carlsson T, Muñoz A, et al. Involvement of the serotonin system in L-dopa-induced dyskinesias. Parkinsonism Relat Disord. 2008;14 Suppl 2:S154-8.
Carta, M., Carlsson, T., Muñoz, A., Kirik, D., & Björklund, A. (2008). Involvement of the serotonin system in L-dopa-induced dyskinesias. Parkinsonism & Related Disorders, 14 Suppl 2, S154-8. https://doi.org/10.1016/j.parkreldis.2008.04.021
Carta M, et al. Involvement of the Serotonin System in L-dopa-induced Dyskinesias. Parkinsonism Relat Disord. 2008;14 Suppl 2:S154-8. PubMed PMID: 18579429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of the serotonin system in L-dopa-induced dyskinesias. AU - Carta,Manolo, AU - Carlsson,Thomas, AU - Muñoz,Ana, AU - Kirik,Deniz, AU - Björklund,Anders, Y1 - 2008/06/24/ PY - 2008/6/27/pubmed PY - 2008/12/17/medline PY - 2008/6/27/entrez SP - S154 EP - 8 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 14 Suppl 2 N2 - The ability of L-dopa to relieve the motor impairments in Parkinson's disease patients declines over time, and side-effects, such as dyskinesias, appear--limiting the use of the drug in the advanced stage of the disease. Serotonergic neurons are able to convert L-dopa to dopamine and to store this neurotransmitter in synaptic vesicles. This peculiarity might be very important in the advanced disease, when most of the dopaminergic neurons have degenerated. Indeed, an increasing body of evidence points to dopamine released as a false neurotransmitter from the serotonin terminals as the main pre-synaptic determinant of L-dopa-induced dyskinesias in animal models of Parkinson's disease. These findings make the serotonin system an intriguing target for anti-dyskinetic therapies. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/18579429/Involvement_of_the_serotonin_system_in_L_dopa_induced_dyskinesias_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(08)00132-6 DB - PRIME DP - Unbound Medicine ER -