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Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women.
Hum Reprod. 2008 Aug; 23(8):1924-31.HR

Abstract

BACKGROUND

We investigated the differences in anthropometrical, hormonal and insulin resistance parameters according to the subtype of polycystic ovary syndrome (PCOS) in Korean women.

METHODS

We recruited 166 women with PCOS and retrospectively recruited 277 controls. PCOS was diagnosed by irregular menstruation (IM), polycystic ovary (PCO) and hyperandrogenism (HA). Subjects were divided into four subgroups: the IM/HA/PCO group (n = 87, 52.4%), the IM/PCO group (n = 52, 31.3%), the IM/HA group (n = 23, 13.9%) and the HA/PCO group (n = 4, 2.4%). Clinical and biochemical variables were compared among the PCOS subgroups.

RESULTS

The IM/HA/PCO and IM/HA groups showed higher body mass index (P < 0.001) and waist-to-hip ratio (P < 0.001) than the IM/PCO group. The IM/HA group had higher triglyceride levels than the other groups (P < 0.001). Higher fasting insulin (P < 0.001) and postprandial 2 h insulin (P < 0.01) were noted in the IM/HA/PCO group and the IM/HA group, compared with the IM/PCO group. Women with PCOS showed lower sex hormone-binding globulin (P < 0.001) and higher systolic blood pressure (BP) (P = 0.004), diastolic BP (P = 0.001), fasting insulin (P < 0.001), postprandial 2 h insulin (P < 0.001), homeostatic model for insulin resistance (P < 0.001) and clinical and biochemical parameters of metabolic syndrome (P < 0.05) compared with subjects without PCOS.

CONCLUSIONS

Women with PCOS without HA are common in Korea and are less likely to have metabolic dysfunction, insulin resistance and elevated BP. PCOS without HA may be a mild phenotype of PCOS. Therefore, women with PCOS in Korea could have a reduced likelihood of having metabolic syndrome compared with women of other ethnicities.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul 110-744, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18579512

Citation

Chae, Soo Jin, et al. "Clinical and Biochemical Characteristics of Polycystic Ovary Syndrome in Korean Women." Human Reproduction (Oxford, England), vol. 23, no. 8, 2008, pp. 1924-31.
Chae SJ, Kim JJ, Choi YM, et al. Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women. Hum Reprod. 2008;23(8):1924-31.
Chae, S. J., Kim, J. J., Choi, Y. M., Hwang, K. R., Jee, B. C., Ku, S. Y., Suh, C. S., Kim, S. H., Kim, J. G., & Moon, S. Y. (2008). Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women. Human Reproduction (Oxford, England), 23(8), 1924-31. https://doi.org/10.1093/humrep/den239
Chae SJ, et al. Clinical and Biochemical Characteristics of Polycystic Ovary Syndrome in Korean Women. Hum Reprod. 2008;23(8):1924-31. PubMed PMID: 18579512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women. AU - Chae,Soo Jin, AU - Kim,Jin Ju, AU - Choi,Young Min, AU - Hwang,Kyu Ri, AU - Jee,Byung Chul, AU - Ku,Seung Yup, AU - Suh,Chang Suk, AU - Kim,Seok Hyun, AU - Kim,Jung Gu, AU - Moon,Shin Yong, Y1 - 2008/06/24/ PY - 2008/6/27/pubmed PY - 2008/9/30/medline PY - 2008/6/27/entrez SP - 1924 EP - 31 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 23 IS - 8 N2 - BACKGROUND: We investigated the differences in anthropometrical, hormonal and insulin resistance parameters according to the subtype of polycystic ovary syndrome (PCOS) in Korean women. METHODS: We recruited 166 women with PCOS and retrospectively recruited 277 controls. PCOS was diagnosed by irregular menstruation (IM), polycystic ovary (PCO) and hyperandrogenism (HA). Subjects were divided into four subgroups: the IM/HA/PCO group (n = 87, 52.4%), the IM/PCO group (n = 52, 31.3%), the IM/HA group (n = 23, 13.9%) and the HA/PCO group (n = 4, 2.4%). Clinical and biochemical variables were compared among the PCOS subgroups. RESULTS: The IM/HA/PCO and IM/HA groups showed higher body mass index (P < 0.001) and waist-to-hip ratio (P < 0.001) than the IM/PCO group. The IM/HA group had higher triglyceride levels than the other groups (P < 0.001). Higher fasting insulin (P < 0.001) and postprandial 2 h insulin (P < 0.01) were noted in the IM/HA/PCO group and the IM/HA group, compared with the IM/PCO group. Women with PCOS showed lower sex hormone-binding globulin (P < 0.001) and higher systolic blood pressure (BP) (P = 0.004), diastolic BP (P = 0.001), fasting insulin (P < 0.001), postprandial 2 h insulin (P < 0.001), homeostatic model for insulin resistance (P < 0.001) and clinical and biochemical parameters of metabolic syndrome (P < 0.05) compared with subjects without PCOS. CONCLUSIONS: Women with PCOS without HA are common in Korea and are less likely to have metabolic dysfunction, insulin resistance and elevated BP. PCOS without HA may be a mild phenotype of PCOS. Therefore, women with PCOS in Korea could have a reduced likelihood of having metabolic syndrome compared with women of other ethnicities. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/18579512/Clinical_and_biochemical_characteristics_of_polycystic_ovary_syndrome_in_Korean_women_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/den239 DB - PRIME DP - Unbound Medicine ER -