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Pulmonary benign metastasizing leiomyoma associated with intravenous leiomyomatosis of the uterus: clinical behavior and genomic changes supporting a transportation theory.
Int J Gynecol Pathol. 2008 Jul; 27(3):340-5.IJ

Abstract

Benign metastasizing leiomyoma is a rare lesion characterized by benign-appearing smooth muscle tumor most frequently involving the lung and usually associated with a benign leiomyoma or intravenous leiomyomatosis of the uterus. The pathogenetic mechanism of the tumor has not been clarified, but the possibilities including hormone-sensitive in situ proliferations of smooth muscle bundles, mechanical displacement or intravascular spread of preexisting benign uterine tumor tissue, and metastasized very low-grade uterine leiomyosarcoma have been proposed. We described a case of pulmonary benign metastasizing leiomyoma associated with a uterine intravenous leiomyomatosis in a 46-year-old woman with a result of comparative genomic hybridization study. The 2 lesions showed significantly overlapping, if not identical, complex genomic changes in the comparative genomic hybridization, suggesting that the 2 lesions are closely related to each other. Unresected pulmonary nodules were left untreated for 13 months after the hysterectomy and wedge biopsy of 3 pulmonary nodules to show no further growth, suggesting clinical behavior of nonmalignant tumor in our case. Benign metastasizing leiomyomas may comprise a heterogeneous group of tumors in terms of their malignant potential and pathogenetic mechanism.

Authors+Show Affiliations

Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18580311

Citation

Lee, Hee Jin, et al. "Pulmonary Benign Metastasizing Leiomyoma Associated With Intravenous Leiomyomatosis of the Uterus: Clinical Behavior and Genomic Changes Supporting a Transportation Theory." International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists, vol. 27, no. 3, 2008, pp. 340-5.
Lee HJ, Choi J, Kim KR. Pulmonary benign metastasizing leiomyoma associated with intravenous leiomyomatosis of the uterus: clinical behavior and genomic changes supporting a transportation theory. Int J Gynecol Pathol. 2008;27(3):340-5.
Lee, H. J., Choi, J., & Kim, K. R. (2008). Pulmonary benign metastasizing leiomyoma associated with intravenous leiomyomatosis of the uterus: clinical behavior and genomic changes supporting a transportation theory. International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists, 27(3), 340-5. https://doi.org/10.1097/PGP.0b013e3181656dab
Lee HJ, Choi J, Kim KR. Pulmonary Benign Metastasizing Leiomyoma Associated With Intravenous Leiomyomatosis of the Uterus: Clinical Behavior and Genomic Changes Supporting a Transportation Theory. Int J Gynecol Pathol. 2008;27(3):340-5. PubMed PMID: 18580311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulmonary benign metastasizing leiomyoma associated with intravenous leiomyomatosis of the uterus: clinical behavior and genomic changes supporting a transportation theory. AU - Lee,Hee Jin, AU - Choi,Jene, AU - Kim,Kyu-Rae, PY - 2008/6/27/pubmed PY - 2008/8/30/medline PY - 2008/6/27/entrez SP - 340 EP - 5 JF - International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists JO - Int. J. Gynecol. Pathol. VL - 27 IS - 3 N2 - Benign metastasizing leiomyoma is a rare lesion characterized by benign-appearing smooth muscle tumor most frequently involving the lung and usually associated with a benign leiomyoma or intravenous leiomyomatosis of the uterus. The pathogenetic mechanism of the tumor has not been clarified, but the possibilities including hormone-sensitive in situ proliferations of smooth muscle bundles, mechanical displacement or intravascular spread of preexisting benign uterine tumor tissue, and metastasized very low-grade uterine leiomyosarcoma have been proposed. We described a case of pulmonary benign metastasizing leiomyoma associated with a uterine intravenous leiomyomatosis in a 46-year-old woman with a result of comparative genomic hybridization study. The 2 lesions showed significantly overlapping, if not identical, complex genomic changes in the comparative genomic hybridization, suggesting that the 2 lesions are closely related to each other. Unresected pulmonary nodules were left untreated for 13 months after the hysterectomy and wedge biopsy of 3 pulmonary nodules to show no further growth, suggesting clinical behavior of nonmalignant tumor in our case. Benign metastasizing leiomyomas may comprise a heterogeneous group of tumors in terms of their malignant potential and pathogenetic mechanism. SN - 1538-7151 UR - https://www.unboundmedicine.com/medline/citation/18580311/Pulmonary_benign_metastasizing_leiomyoma_associated_with_intravenous_leiomyomatosis_of_the_uterus:_clinical_behavior_and_genomic_changes_supporting_a_transportation_theory_ L2 - http://dx.doi.org/10.1097/PGP.0b013e3181656dab DB - PRIME DP - Unbound Medicine ER -