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Effects of acute salbutamol inhalation on quadriceps force and fatigability.
Med Sci Sports Exerc. 2008 Jul; 40(7):1220-7.MS

Abstract

INTRODUCTION

Oral beta2-agonist administration improves muscle function in persons without asthma. We performed a double-blind, randomized, controlled crossover study to assess whether acute inhaled salbutamol administration improves muscle strength and fatigability in healthy moderately trained subjects.

METHODS

Quadriceps muscle strength was measured during maximal voluntary contraction (MVC) and femoral nerve magnetic stimulation (potentiated single twitch, TwQpeak) before and after (i) a maximal incremental cycling test (n = 10) and (ii) 50 maximal isometric one-leg extensions (n = 9). Each exercise test was performed on three occasions, after salbutamol (200 and 800 microg) or placebo inhalation.

RESULTS

Before exercise, treatments had no significant effect on MVC [(placebo) 597 +/- 146 N vs (200 microg) 629 +/- 151 N vs (800 microg) 610 +/- 148 N] and TwQpeak [(placebo) 215 +/- 83 N vs (200 microg) 227 +/- 69 N vs (800 microg) 250 +/- 84 N]. Maximal power during cycling and maximal force during leg extensions did not differ between treatments. Treatments had no effect on MVC and TwQpeak reductions at 30 min [MVC: (placebo) -8 +/- 9% vs (200 microg) -9 +/- 7% vs (800 microg) -8 +/- 5%; TwQpeak: (placebo) -29 +/- 13% vs (200 microg) -23 +/- 15% vs (800 microg) -20 +/- 8%] and 60 min [MVC: (placebo) -12 +/- 17% vs (200 microg) -6 +/- 9% vs (800 microg) -8 +/- 8%; TwQpeak: (placebo) -20 +/- 21% vs (200 microg) -19 +/- 23% vs (800 microg) -8 +/- 7%] after cycling. Similarly, reductions in MVC and TwQpeak were not significantly different between treatments at 30 [MVC: (placebo) -11 +/- 9% vs (200 microg) -12 +/- 7% vs (800 microg) -8+/- 16%; TwQpeak: (placebo) -37 +/- 12% vs (200 microg) -33 +/- 20% vs (800 microg) -32 +/- 16%] and 60 min [MVC: (placebo) -10 +/- 11% vs (200microg) -11 +/- 6% vs (800 microg) -8 +/- 20%; TwQpeak: (placebo) -30 +/- 11% vs (200 microg) -28 +/- 24% vs (800 microg) -27 +/- 15%] after leg extensions. Treatments did not modify maximal voluntary activation at any time of the protocol.

CONCLUSION

Acute therapeutic or supratherapeutic doses of inhaled salbutamol have no effect on quadriceps strength, fatigue, and recovery in men without asthma.

Authors+Show Affiliations

REX-S Laboratory, Joseph Fourier University and UF Exercise Research, Grenoble University Hospital, Grenoble, FRANCE.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18580400

Citation

Decorte, Nicolas, et al. "Effects of Acute Salbutamol Inhalation On Quadriceps Force and Fatigability." Medicine and Science in Sports and Exercise, vol. 40, no. 7, 2008, pp. 1220-7.
Decorte N, Verges S, Flore P, et al. Effects of acute salbutamol inhalation on quadriceps force and fatigability. Med Sci Sports Exerc. 2008;40(7):1220-7.
Decorte, N., Verges, S., Flore, P., Guinot, M., & Wuyam, B. (2008). Effects of acute salbutamol inhalation on quadriceps force and fatigability. Medicine and Science in Sports and Exercise, 40(7), 1220-7. https://doi.org/10.1249/MSS.0b013e31816b87aa
Decorte N, et al. Effects of Acute Salbutamol Inhalation On Quadriceps Force and Fatigability. Med Sci Sports Exerc. 2008;40(7):1220-7. PubMed PMID: 18580400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute salbutamol inhalation on quadriceps force and fatigability. AU - Decorte,Nicolas, AU - Verges,Samuel, AU - Flore,Patrice, AU - Guinot,Michel, AU - Wuyam,Bernard, PY - 2008/6/27/pubmed PY - 2010/8/13/medline PY - 2008/6/27/entrez SP - 1220 EP - 7 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 40 IS - 7 N2 - INTRODUCTION: Oral beta2-agonist administration improves muscle function in persons without asthma. We performed a double-blind, randomized, controlled crossover study to assess whether acute inhaled salbutamol administration improves muscle strength and fatigability in healthy moderately trained subjects. METHODS: Quadriceps muscle strength was measured during maximal voluntary contraction (MVC) and femoral nerve magnetic stimulation (potentiated single twitch, TwQpeak) before and after (i) a maximal incremental cycling test (n = 10) and (ii) 50 maximal isometric one-leg extensions (n = 9). Each exercise test was performed on three occasions, after salbutamol (200 and 800 microg) or placebo inhalation. RESULTS: Before exercise, treatments had no significant effect on MVC [(placebo) 597 +/- 146 N vs (200 microg) 629 +/- 151 N vs (800 microg) 610 +/- 148 N] and TwQpeak [(placebo) 215 +/- 83 N vs (200 microg) 227 +/- 69 N vs (800 microg) 250 +/- 84 N]. Maximal power during cycling and maximal force during leg extensions did not differ between treatments. Treatments had no effect on MVC and TwQpeak reductions at 30 min [MVC: (placebo) -8 +/- 9% vs (200 microg) -9 +/- 7% vs (800 microg) -8 +/- 5%; TwQpeak: (placebo) -29 +/- 13% vs (200 microg) -23 +/- 15% vs (800 microg) -20 +/- 8%] and 60 min [MVC: (placebo) -12 +/- 17% vs (200 microg) -6 +/- 9% vs (800 microg) -8 +/- 8%; TwQpeak: (placebo) -20 +/- 21% vs (200 microg) -19 +/- 23% vs (800 microg) -8 +/- 7%] after cycling. Similarly, reductions in MVC and TwQpeak were not significantly different between treatments at 30 [MVC: (placebo) -11 +/- 9% vs (200 microg) -12 +/- 7% vs (800 microg) -8+/- 16%; TwQpeak: (placebo) -37 +/- 12% vs (200 microg) -33 +/- 20% vs (800 microg) -32 +/- 16%] and 60 min [MVC: (placebo) -10 +/- 11% vs (200microg) -11 +/- 6% vs (800 microg) -8 +/- 20%; TwQpeak: (placebo) -30 +/- 11% vs (200 microg) -28 +/- 24% vs (800 microg) -27 +/- 15%] after leg extensions. Treatments did not modify maximal voluntary activation at any time of the protocol. CONCLUSION: Acute therapeutic or supratherapeutic doses of inhaled salbutamol have no effect on quadriceps strength, fatigue, and recovery in men without asthma. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/18580400/Effects_of_acute_salbutamol_inhalation_on_quadriceps_force_and_fatigability_ L2 - http://dx.doi.org/10.1249/MSS.0b013e31816b87aa DB - PRIME DP - Unbound Medicine ER -