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Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning.
Brain Res Bull. 2008 Sep 30; 77(2-3):71-6.BR

Abstract

A number of studies have suggested that the glutamatergic and cholinergic systems are both involved in learning and memory processes and that they interact in order to facilitate these processes. However, the role of M1-muscarinic receptors in mediating this interaction has not been elucidated. The aim of this study was to determine whether the concomitant administration of MK-801 (non-competitive NMDA antagonist) and dicyclomine (M1-muscarinic antagonist--DIC) in sub-effective doses impairs contextual fear conditioning (hippocampal-dependent task) and tone fear conditioning tasks (hippocampal-independent task). The results showed that concomitant pre-training administration of DIC (8.0 mg/kg) and MK-801 (0.07 mg/kg)--two sub-effectives doses for the contextual fear conditioning task--does impair the performance of animals on this task (as measured by freezing behavior time). Tone fear conditioning tasks were not affected by the drugs either administered separately or concurrently. The pre-training administration of sub-effective doses of MK-801 and DIC in combination impairs performance on contextual fear conditioning task (hippocampal-dependent), but not on tone fear conditioning task (hippocampal-independent). These data support the hypothesis that the interaction between glutamatergic and cholinergic systems in hippocampus-dependent learning and memory processes probably occurs through M1 receptor.

Authors+Show Affiliations

Universidade Federal de São Paulo, Departamento de Psicobiologia, São Paulo, SP, Brazil. lzfigueredo@psicobio.epm.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18582541

Citation

Figueredo, Larissa Zeggio Perez, et al. "Interaction Between glutamatergic-NMDA and Cholinergic-muscarinic Systems in Classical Fear Conditioning." Brain Research Bulletin, vol. 77, no. 2-3, 2008, pp. 71-6.
Figueredo LZ, Moreira KM, Ferreira TL, et al. Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning. Brain Res Bull. 2008;77(2-3):71-6.
Figueredo, L. Z., Moreira, K. M., Ferreira, T. L., Fornari, R. V., & Oliveira, M. G. (2008). Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning. Brain Research Bulletin, 77(2-3), 71-6. https://doi.org/10.1016/j.brainresbull.2008.05.008
Figueredo LZ, et al. Interaction Between glutamatergic-NMDA and Cholinergic-muscarinic Systems in Classical Fear Conditioning. Brain Res Bull. 2008 Sep 30;77(2-3):71-6. PubMed PMID: 18582541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning. AU - Figueredo,Larissa Zeggio Perez, AU - Moreira,Karin Monteiro, AU - Ferreira,Tatiana Lima, AU - Fornari,Raquel Vecchio, AU - Oliveira,Maria Gabriela Menezes, Y1 - 2008/06/26/ PY - 2007/12/07/received PY - 2008/05/18/revised PY - 2008/05/28/accepted PY - 2008/6/28/pubmed PY - 2008/10/7/medline PY - 2008/6/28/entrez SP - 71 EP - 6 JF - Brain research bulletin JO - Brain Res Bull VL - 77 IS - 2-3 N2 - A number of studies have suggested that the glutamatergic and cholinergic systems are both involved in learning and memory processes and that they interact in order to facilitate these processes. However, the role of M1-muscarinic receptors in mediating this interaction has not been elucidated. The aim of this study was to determine whether the concomitant administration of MK-801 (non-competitive NMDA antagonist) and dicyclomine (M1-muscarinic antagonist--DIC) in sub-effective doses impairs contextual fear conditioning (hippocampal-dependent task) and tone fear conditioning tasks (hippocampal-independent task). The results showed that concomitant pre-training administration of DIC (8.0 mg/kg) and MK-801 (0.07 mg/kg)--two sub-effectives doses for the contextual fear conditioning task--does impair the performance of animals on this task (as measured by freezing behavior time). Tone fear conditioning tasks were not affected by the drugs either administered separately or concurrently. The pre-training administration of sub-effective doses of MK-801 and DIC in combination impairs performance on contextual fear conditioning task (hippocampal-dependent), but not on tone fear conditioning task (hippocampal-independent). These data support the hypothesis that the interaction between glutamatergic and cholinergic systems in hippocampus-dependent learning and memory processes probably occurs through M1 receptor. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/18582541/Interaction_between_glutamatergic_NMDA_and_cholinergic_muscarinic_systems_in_classical_fear_conditioning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(08)00220-7 DB - PRIME DP - Unbound Medicine ER -