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Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis.
Neurosci Lett 2008; 440(3):237-41NL

Abstract

Transient receptor potential ankyrin-1 (TRPA1) is an important receptor that contributes to inflammatory pain. However, previous studies were mainly concerned with its function in somatic hyperalgesia while few referred to visceral, especially colonic inflammatory hyperalgesia. The present study was aimed to investigate the role of TRPA1 in visceral hyperalgesia after trinitrobenzene sulfonic acid (TNBS)-induced colitis. Results indicate that TNBS induced a significant increase in visceral sensitivity to colonic distension and chemical irritation accompanied by up-regulation of TRPA1 in colonic afferent dorsal root ganglia (DRG). Intrathecal administration of TRPA1 antisense (AS) oligodeoxynucleotide (ODN) reduced the TRPA1 expression in DRG as well as suppressed the colitis-induced hyperalgesia to nociceptive colonic distension and intracolonic allyl isothiocyanate (AITC). Meanwhile the TRPA1 antisense ODN had no effect on transient receptor potential vanilloid-1 (TRPV1) expression, which was proposed to highly co-express with TRPA1, and no effect on the response to TRPV1 agonist, capsaicin. These data suggest an apparent role of TRPA1 in visceral hyperalgesia following colitis that might provide a novel therapeutic target for the relief of pain.

Authors+Show Affiliations

Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, China. liyangqing@sdu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18583045

Citation

Yang, Jing, et al. "Transient Receptor Potential Ankyrin-1 Participates in Visceral Hyperalgesia Following Experimental Colitis." Neuroscience Letters, vol. 440, no. 3, 2008, pp. 237-41.
Yang J, Li Y, Zuo X, et al. Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis. Neurosci Lett. 2008;440(3):237-41.
Yang, J., Li, Y., Zuo, X., Zhen, Y., Yu, Y., & Gao, L. (2008). Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis. Neuroscience Letters, 440(3), pp. 237-41. doi:10.1016/j.neulet.2008.05.093.
Yang J, et al. Transient Receptor Potential Ankyrin-1 Participates in Visceral Hyperalgesia Following Experimental Colitis. Neurosci Lett. 2008 Aug 8;440(3):237-41. PubMed PMID: 18583045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis. AU - Yang,Jing, AU - Li,Yanqing, AU - Zuo,Xiuli, AU - Zhen,Yanbo, AU - Yu,Yanbo, AU - Gao,Lijun, Y1 - 2008/06/24/ PY - 2008/04/16/received PY - 2008/05/23/revised PY - 2008/05/24/accepted PY - 2008/6/28/pubmed PY - 2008/11/6/medline PY - 2008/6/28/entrez SP - 237 EP - 41 JF - Neuroscience letters JO - Neurosci. Lett. VL - 440 IS - 3 N2 - Transient receptor potential ankyrin-1 (TRPA1) is an important receptor that contributes to inflammatory pain. However, previous studies were mainly concerned with its function in somatic hyperalgesia while few referred to visceral, especially colonic inflammatory hyperalgesia. The present study was aimed to investigate the role of TRPA1 in visceral hyperalgesia after trinitrobenzene sulfonic acid (TNBS)-induced colitis. Results indicate that TNBS induced a significant increase in visceral sensitivity to colonic distension and chemical irritation accompanied by up-regulation of TRPA1 in colonic afferent dorsal root ganglia (DRG). Intrathecal administration of TRPA1 antisense (AS) oligodeoxynucleotide (ODN) reduced the TRPA1 expression in DRG as well as suppressed the colitis-induced hyperalgesia to nociceptive colonic distension and intracolonic allyl isothiocyanate (AITC). Meanwhile the TRPA1 antisense ODN had no effect on transient receptor potential vanilloid-1 (TRPV1) expression, which was proposed to highly co-express with TRPA1, and no effect on the response to TRPV1 agonist, capsaicin. These data suggest an apparent role of TRPA1 in visceral hyperalgesia following colitis that might provide a novel therapeutic target for the relief of pain. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/18583045/Transient_receptor_potential_ankyrin_1_participates_in_visceral_hyperalgesia_following_experimental_colitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(08)00758-1 DB - PRIME DP - Unbound Medicine ER -