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The synthesis of biodegradable graft copolymer cellulose-graft-poly(L-lactide) and the study of its controlled drug release.
Colloids Surf B Biointerfaces 2008; 66(1):26-33CS

Abstract

According to the concept of green chemistry and sustainable development, a new biodegradable copolymer comprised of hydrophobic poly(l-lactide) (PLLA) segments and hydrophilic cellulose segment (cellulose-g-PLLA) was designed and synthesized. The structure of the copolymer was characterized by (1)H NMR, FT-IR, (13)C NMR, DSC and WAXD. The cytotoxicity study shows that cellulose-g-PLLA exhibits good biocompatibility. The copolymer can self-assemble into micelles in water with the hydrophobic PLLA segments at the cores of micelles and the hydrophilic cellulose segments as the outer shells. Transmission electron microscopy (TEM) shows that the micelles exhibit nanospheric morphology within a size range of 30-80nm. The drug loaded micelles formed by the copolymer in aqueous media show sustained drug release which indicates their potential applicability in drug carrier.

Authors+Show Affiliations

Department of Polymer Science, Key Laboratory of Biomedical Polymers, Wuhan University, Ministry of Education, Wuhan 430072, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18583109

Citation

Dong, Haiqing, et al. "The Synthesis of Biodegradable Graft Copolymer cellulose-graft-poly(L-lactide) and the Study of Its Controlled Drug Release." Colloids and Surfaces. B, Biointerfaces, vol. 66, no. 1, 2008, pp. 26-33.
Dong H, Xu Q, Li Y, et al. The synthesis of biodegradable graft copolymer cellulose-graft-poly(L-lactide) and the study of its controlled drug release. Colloids Surf B Biointerfaces. 2008;66(1):26-33.
Dong, H., Xu, Q., Li, Y., Mo, S., Cai, S., & Liu, L. (2008). The synthesis of biodegradable graft copolymer cellulose-graft-poly(L-lactide) and the study of its controlled drug release. Colloids and Surfaces. B, Biointerfaces, 66(1), pp. 26-33. doi:10.1016/j.colsurfb.2008.05.007.
Dong H, et al. The Synthesis of Biodegradable Graft Copolymer cellulose-graft-poly(L-lactide) and the Study of Its Controlled Drug Release. Colloids Surf B Biointerfaces. 2008 Oct 1;66(1):26-33. PubMed PMID: 18583109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The synthesis of biodegradable graft copolymer cellulose-graft-poly(L-lactide) and the study of its controlled drug release. AU - Dong,Haiqing, AU - Xu,Qi, AU - Li,Yongyong, AU - Mo,Shaobo, AU - Cai,Shaojun, AU - Liu,Lijian, Y1 - 2008/05/20/ PY - 2008/01/30/received PY - 2008/04/17/revised PY - 2008/05/09/accepted PY - 2008/6/28/pubmed PY - 2008/11/11/medline PY - 2008/6/28/entrez SP - 26 EP - 33 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 66 IS - 1 N2 - According to the concept of green chemistry and sustainable development, a new biodegradable copolymer comprised of hydrophobic poly(l-lactide) (PLLA) segments and hydrophilic cellulose segment (cellulose-g-PLLA) was designed and synthesized. The structure of the copolymer was characterized by (1)H NMR, FT-IR, (13)C NMR, DSC and WAXD. The cytotoxicity study shows that cellulose-g-PLLA exhibits good biocompatibility. The copolymer can self-assemble into micelles in water with the hydrophobic PLLA segments at the cores of micelles and the hydrophilic cellulose segments as the outer shells. Transmission electron microscopy (TEM) shows that the micelles exhibit nanospheric morphology within a size range of 30-80nm. The drug loaded micelles formed by the copolymer in aqueous media show sustained drug release which indicates their potential applicability in drug carrier. SN - 0927-7765 UR - https://www.unboundmedicine.com/medline/citation/18583109/The_synthesis_of_biodegradable_graft_copolymer_cellulose_graft_poly_L_lactide__and_the_study_of_its_controlled_drug_release_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(08)00187-2 DB - PRIME DP - Unbound Medicine ER -