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Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: Significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis.
Gynecol Endocrinol. 2008 Jun; 24(6):326-30.GE

Abstract

Endometriosis is a highly prevalent gynecological condition, where the formation of endometriotic foci is linked with locally increased activity of matrix metalloproteinases (MMPs). In the present study, we tested the hypothesis that raised serum levels of MMPs might reflect the severity of endometriosis. We compared serum levels of MMP-2 and MMP-9, and of their tissue inhibitors TIMP-1 and TIMP-2, in infertile women, matched for age and body mass index, with either mild (stage I, END-I; n = 15) or severe endometriosis (stage IV, END-IV; n = 22). There was no difference in the concentrations of MMP-2, MMP-9, TIMP-1 and TIMP-2 between the analyzed groups. There was, however, a correlation between MMP-9 and TIMP-1 for the combined group (n = 37) (r = 0.48; p = 0.0032) and in women with END-IV (r = 0.51; p = 0.0163), as well as a highly significant correlation between MMP-2 and TIMP-2 for the combined group (r = 0.69; p = 0.0001), END-I (r = 0.51; p = 0.0406) and END-IV groups (r = 0.77; p = 0.0001). There was also a significant correlation between TIMP-1 and TIMP-2 in the combined and END-IV groups (r = 0.39; p = 0.0182 and r = 0.5450; p = 0.0099, respectively). The balance between MMPs and their inhibitors is preserved in the serum of women with endometriosis, but serum concentrations of MMP-2, MMP-9, TIMP-1 and TIMP-2 cannot be considered to represent a valid measure of the severity of endometriosis.

Authors+Show Affiliations

Department of Endocrinology and Metabolic Diseases, The Medical University of Lodz and Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18584412

Citation

Salata, Ireneusz M., et al. "Gelatinase a (MM-2), Gelatinase B (MMP-9) and Their Inhibitors (TIMP 1, TIMP-2) in Serum of Women With Endometriosis: Significant Correlation Between MMP-2, MMP-9 and Their Inhibitors Without Difference in Levels of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Relation to the Severity of Endometriosis." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 24, no. 6, 2008, pp. 326-30.
Salata IM, Stojanovic N, Cajdler-Łuba A, et al. Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: Significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis. Gynecol Endocrinol. 2008;24(6):326-30.
Salata, I. M., Stojanovic, N., Cajdler-Łuba, A., Lewandowski, K. C., & Lewiński, A. (2008). Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: Significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 24(6), 326-30. https://doi.org/10.1080/09513590802090325
Salata IM, et al. Gelatinase a (MM-2), Gelatinase B (MMP-9) and Their Inhibitors (TIMP 1, TIMP-2) in Serum of Women With Endometriosis: Significant Correlation Between MMP-2, MMP-9 and Their Inhibitors Without Difference in Levels of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Relation to the Severity of Endometriosis. Gynecol Endocrinol. 2008;24(6):326-30. PubMed PMID: 18584412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: Significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis. AU - Salata,Ireneusz M, AU - Stojanovic,Nemanja, AU - Cajdler-Łuba,Agata, AU - Lewandowski,Krzysztof C, AU - Lewiński,Andrzej, PY - 2008/6/28/pubmed PY - 2008/9/19/medline PY - 2008/6/28/entrez SP - 326 EP - 30 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 24 IS - 6 N2 - Endometriosis is a highly prevalent gynecological condition, where the formation of endometriotic foci is linked with locally increased activity of matrix metalloproteinases (MMPs). In the present study, we tested the hypothesis that raised serum levels of MMPs might reflect the severity of endometriosis. We compared serum levels of MMP-2 and MMP-9, and of their tissue inhibitors TIMP-1 and TIMP-2, in infertile women, matched for age and body mass index, with either mild (stage I, END-I; n = 15) or severe endometriosis (stage IV, END-IV; n = 22). There was no difference in the concentrations of MMP-2, MMP-9, TIMP-1 and TIMP-2 between the analyzed groups. There was, however, a correlation between MMP-9 and TIMP-1 for the combined group (n = 37) (r = 0.48; p = 0.0032) and in women with END-IV (r = 0.51; p = 0.0163), as well as a highly significant correlation between MMP-2 and TIMP-2 for the combined group (r = 0.69; p = 0.0001), END-I (r = 0.51; p = 0.0406) and END-IV groups (r = 0.77; p = 0.0001). There was also a significant correlation between TIMP-1 and TIMP-2 in the combined and END-IV groups (r = 0.39; p = 0.0182 and r = 0.5450; p = 0.0099, respectively). The balance between MMPs and their inhibitors is preserved in the serum of women with endometriosis, but serum concentrations of MMP-2, MMP-9, TIMP-1 and TIMP-2 cannot be considered to represent a valid measure of the severity of endometriosis. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/18584412/Gelatinase_A__MM_2__gelatinase_B__MMP_9__and_their_inhibitors__TIMP_1_TIMP_2__in_serum_of_women_with_endometriosis:_Significant_correlation_between_MMP_2_MMP_9_and_their_inhibitors_without_difference_in_levels_of_matrix_metalloproteinases_and_tissue_inhibitors_of_metalloproteinases_in_relation_to_the_severity_of_endometriosis_ L2 - https://www.tandfonline.com/doi/full/10.1080/09513590802090325 DB - PRIME DP - Unbound Medicine ER -