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Effects of anti herpetic drugs on mice with herpetic epithelial keratitis after reactivation of herpes simplex virus type 1.
Semin Ophthalmol. 2008 Jul-Aug; 23(4):241-7.SO

Abstract

To compare the efficacies of valacyclovir (VCV) and acyclovir (ACV) on murine herpetic epithelial keratitis, mice inoculated with herpes simplex virus type 1(HSV-1) strain McKrae were divided into 6 treatment groups: oral VCV 50 mg/kg and 100 mg/kg, oral ACV 50 mg/kg, ACV eye ointment (EO), ACV eye drops (ED), and placebo. Keratitis scores showed that oral VCV 50 mg/kg, oral ACV, and ACV ED had equivalent efficacies, while oral VCV 100 mg/kg was as efficacious as ACV EO during acute infection. Each treatment group was further divided into the stimulated group with HSV-1 reactivation by immunosuppressant drugs and hyperthermia, and the non-stimulated group without reactivation. We assessed the virus titers in tissues by plaque assay and HSV DNA copy number in the trigeminal ganglia (TG) by real time polymerase chain reaction (PCR). Results showed that the virus titers in the tissues were lowered after reactivation, and the oral VCV group with reactivation had significantly reduced DNA copy number in the TG than the same treatment group without reactivation. In conclusion, oral VCV is as efficacious as ACV EO and significantly suppresses HSV-1 reactivation.

Authors+Show Affiliations

Department of Ophthalmology, Kinki University School of Medicine, Osaka-Sayama, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18584562

Citation

Itahashi, Motoki, et al. "Effects of Anti Herpetic Drugs On Mice With Herpetic Epithelial Keratitis After Reactivation of Herpes Simplex Virus Type 1." Seminars in Ophthalmology, vol. 23, no. 4, 2008, pp. 241-7.
Itahashi M, Higaki S, Shimomura Y. Effects of anti herpetic drugs on mice with herpetic epithelial keratitis after reactivation of herpes simplex virus type 1. Semin Ophthalmol. 2008;23(4):241-7.
Itahashi, M., Higaki, S., & Shimomura, Y. (2008). Effects of anti herpetic drugs on mice with herpetic epithelial keratitis after reactivation of herpes simplex virus type 1. Seminars in Ophthalmology, 23(4), 241-7. https://doi.org/10.1080/08820530802111291
Itahashi M, Higaki S, Shimomura Y. Effects of Anti Herpetic Drugs On Mice With Herpetic Epithelial Keratitis After Reactivation of Herpes Simplex Virus Type 1. Semin Ophthalmol. 2008 Jul-Aug;23(4):241-7. PubMed PMID: 18584562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of anti herpetic drugs on mice with herpetic epithelial keratitis after reactivation of herpes simplex virus type 1. AU - Itahashi,Motoki, AU - Higaki,Shiro, AU - Shimomura,Yoshikazu, PY - 2008/6/28/pubmed PY - 2008/9/5/medline PY - 2008/6/28/entrez SP - 241 EP - 7 JF - Seminars in ophthalmology JO - Semin Ophthalmol VL - 23 IS - 4 N2 - To compare the efficacies of valacyclovir (VCV) and acyclovir (ACV) on murine herpetic epithelial keratitis, mice inoculated with herpes simplex virus type 1(HSV-1) strain McKrae were divided into 6 treatment groups: oral VCV 50 mg/kg and 100 mg/kg, oral ACV 50 mg/kg, ACV eye ointment (EO), ACV eye drops (ED), and placebo. Keratitis scores showed that oral VCV 50 mg/kg, oral ACV, and ACV ED had equivalent efficacies, while oral VCV 100 mg/kg was as efficacious as ACV EO during acute infection. Each treatment group was further divided into the stimulated group with HSV-1 reactivation by immunosuppressant drugs and hyperthermia, and the non-stimulated group without reactivation. We assessed the virus titers in tissues by plaque assay and HSV DNA copy number in the trigeminal ganglia (TG) by real time polymerase chain reaction (PCR). Results showed that the virus titers in the tissues were lowered after reactivation, and the oral VCV group with reactivation had significantly reduced DNA copy number in the TG than the same treatment group without reactivation. In conclusion, oral VCV is as efficacious as ACV EO and significantly suppresses HSV-1 reactivation. SN - 0882-0538 UR - https://www.unboundmedicine.com/medline/citation/18584562/Effects_of_anti_herpetic_drugs_on_mice_with_herpetic_epithelial_keratitis_after_reactivation_of_herpes_simplex_virus_type_1_ L2 - http://www.tandfonline.com/doi/full/10.1080/08820530802111291 DB - PRIME DP - Unbound Medicine ER -