Tags

Type your tag names separated by a space and hit enter

Effect of losartan on exercise tolerance and echocardiographic parameters in patients with mitral regurgitation.
J Renin Angiotensin Aldosterone Syst. 2008 Jun; 9(2):107-11.JR

Abstract

OBJECTIVES

The aim of this study was to assess the effects of losartan treatment on exercise tolerance and echocardiographic parameters in patients with mitral regurgitation (MR) secondary to mitral valve prolapse or rheumatic heart disease.

METHODS

Twenty-seven patients (14 males, 13 females, mean age 51+/-11, range 21-76) with moderate MR due to mitral valve prolapse or rheumatic heart disease were examined by means of Doppler echocardiography. The subjects were submitted to treadmill exercise tests using the modified Bruce protocol at baseline, after six hours and after the six-week treatment period to be evaluated based on their exercise tolerance. Mitral Regurgitant Volume (MRV), effective regurgitant orifice diameter, left atrial volume, left ventricle (LV) end-diastolic volume index, LV end-systolic volume index, LV ejection fraction (LVEF), left ventricle mass index were calculated at baseline and after six weeks of treatment with single dose of losartan (50 mg/day).

RESULTS

Total treadmill exercise time increased from 477.7+/-147.9 to 535.7+/-149.0 seconds after six hours (p<0.01) and to 559.6+/-142.8 seconds after six weeks of treatment. Also, metabolic equivalent values increased following six hours of first dose and six weeks of losartan treatment (from 10.9+/-2.9 to 11.8+/-3.1, p=0.006 and 12.4+/-3.1, p=0.002; respectively). However, peak exercise systolic blood pressure (BP) was reduced after six hours and six weeks of treatment, and resting diastolic BP did not change after six hours but reduced at the end of the treatment period. MR volume decreased significantly from 29.3+/-14.1 ml to 25.1+/-14.8 ml, (p=0.025) without significant change in regurgitant orifice diameter (0.72+/-0.37 cm vs. 0.66+/-0.37 cm, p=NS), left atrium diameter and area while LVEF increased from 51.70+/-13.37 to 54.11-11.75 (p=0.015) with losartan.

CONCLUSION

We conclude that the angiotensin II receptor antagonist losartan improves exercise tolerance and echocardiographic parameters in patients with moderate MR.

Authors+Show Affiliations

Kent Hospital, Department of Cardiology, Izmir, Turkey. csekuri@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18584587

Citation

Sekuri, Cevad, et al. "Effect of Losartan On Exercise Tolerance and Echocardiographic Parameters in Patients With Mitral Regurgitation." Journal of the Renin-angiotensin-aldosterone System : JRAAS, vol. 9, no. 2, 2008, pp. 107-11.
Sekuri C, Utuk O, Bayturan O, et al. Effect of losartan on exercise tolerance and echocardiographic parameters in patients with mitral regurgitation. J Renin Angiotensin Aldosterone Syst. 2008;9(2):107-11.
Sekuri, C., Utuk, O., Bayturan, O., Bilge, A., Kurhan, Z., & Tavli, T. (2008). Effect of losartan on exercise tolerance and echocardiographic parameters in patients with mitral regurgitation. Journal of the Renin-angiotensin-aldosterone System : JRAAS, 9(2), 107-11. https://doi.org/10.3317/jraas.2008.016
Sekuri C, et al. Effect of Losartan On Exercise Tolerance and Echocardiographic Parameters in Patients With Mitral Regurgitation. J Renin Angiotensin Aldosterone Syst. 2008;9(2):107-11. PubMed PMID: 18584587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of losartan on exercise tolerance and echocardiographic parameters in patients with mitral regurgitation. AU - Sekuri,Cevad, AU - Utuk,Ozan, AU - Bayturan,Ozgur, AU - Bilge,Ali, AU - Kurhan,Ziya, AU - Tavli,Talat, PY - 2008/6/28/pubmed PY - 2008/9/11/medline PY - 2008/6/28/entrez SP - 107 EP - 11 JF - Journal of the renin-angiotensin-aldosterone system : JRAAS JO - J Renin Angiotensin Aldosterone Syst VL - 9 IS - 2 N2 - OBJECTIVES: The aim of this study was to assess the effects of losartan treatment on exercise tolerance and echocardiographic parameters in patients with mitral regurgitation (MR) secondary to mitral valve prolapse or rheumatic heart disease. METHODS: Twenty-seven patients (14 males, 13 females, mean age 51+/-11, range 21-76) with moderate MR due to mitral valve prolapse or rheumatic heart disease were examined by means of Doppler echocardiography. The subjects were submitted to treadmill exercise tests using the modified Bruce protocol at baseline, after six hours and after the six-week treatment period to be evaluated based on their exercise tolerance. Mitral Regurgitant Volume (MRV), effective regurgitant orifice diameter, left atrial volume, left ventricle (LV) end-diastolic volume index, LV end-systolic volume index, LV ejection fraction (LVEF), left ventricle mass index were calculated at baseline and after six weeks of treatment with single dose of losartan (50 mg/day). RESULTS: Total treadmill exercise time increased from 477.7+/-147.9 to 535.7+/-149.0 seconds after six hours (p<0.01) and to 559.6+/-142.8 seconds after six weeks of treatment. Also, metabolic equivalent values increased following six hours of first dose and six weeks of losartan treatment (from 10.9+/-2.9 to 11.8+/-3.1, p=0.006 and 12.4+/-3.1, p=0.002; respectively). However, peak exercise systolic blood pressure (BP) was reduced after six hours and six weeks of treatment, and resting diastolic BP did not change after six hours but reduced at the end of the treatment period. MR volume decreased significantly from 29.3+/-14.1 ml to 25.1+/-14.8 ml, (p=0.025) without significant change in regurgitant orifice diameter (0.72+/-0.37 cm vs. 0.66+/-0.37 cm, p=NS), left atrium diameter and area while LVEF increased from 51.70+/-13.37 to 54.11-11.75 (p=0.015) with losartan. CONCLUSION: We conclude that the angiotensin II receptor antagonist losartan improves exercise tolerance and echocardiographic parameters in patients with moderate MR. SN - 1470-3203 UR - https://www.unboundmedicine.com/medline/citation/18584587/Effect_of_losartan_on_exercise_tolerance_and_echocardiographic_parameters_in_patients_with_mitral_regurgitation_ L2 - https://journals.sagepub.com/doi/10.3317/jraas.2008.016?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -