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Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures--a short review.
Pharmacol Biochem Behav. 2008 Oct; 90(4):501-11.PB

Abstract

In the last 25 years data has grown exponentially dealing with the discovery of the endocannabinoid system consisting of specific cannabinoid receptors, their endogenous ligands, and enzymatic systems of their biosynthesis and degradation. Progress is being made in the development of novel agonists and antagonists with receptor subtype selectivity which should help in providing a greater understanding of the physiological role of the endocannabinoid system and perhaps also in a broad number of pathologies. This could lead to advances with important therapeutic potential of drugs modulating activity of endocannabinoid system as hypnotics, analgesics, antiemetics, antiasthmatics, antihypertensives, immunomodulatory drugs, antiphlogistics, neuroprotective agents, antiepileptics, agents influencing glaucoma, spasticity and other "movement disorders", eating disorders, alcohol withdrawal, hepatic fibrosis, bone growth, and atherosclerosis. The aim of this review is to highlight distribution of the CB1 and CB2 receptor subtypes in the nervous system and functional involvement of their specific ligands.

Authors+Show Affiliations

Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine, Masaryk University, Kamenice 3, CZ-625 00 Brno, Czech Republic. isvizen@med.muni.czNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18584858

Citation

Svízenská, Ivana, et al. "Cannabinoid Receptors 1 and 2 (CB1 and CB2), Their Distribution, Ligands and Functional Involvement in Nervous System Structures--a Short Review." Pharmacology, Biochemistry, and Behavior, vol. 90, no. 4, 2008, pp. 501-11.
Svízenská I, Dubový P, Sulcová A. Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures--a short review. Pharmacol Biochem Behav. 2008;90(4):501-11.
Svízenská, I., Dubový, P., & Sulcová, A. (2008). Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures--a short review. Pharmacology, Biochemistry, and Behavior, 90(4), 501-11. https://doi.org/10.1016/j.pbb.2008.05.010
Svízenská I, Dubový P, Sulcová A. Cannabinoid Receptors 1 and 2 (CB1 and CB2), Their Distribution, Ligands and Functional Involvement in Nervous System Structures--a Short Review. Pharmacol Biochem Behav. 2008;90(4):501-11. PubMed PMID: 18584858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures--a short review. AU - Svízenská,Ivana, AU - Dubový,Petr, AU - Sulcová,Alexandra, PY - 2008/02/04/received PY - 2008/05/14/revised PY - 2008/05/20/accepted PY - 2008/7/1/pubmed PY - 2008/12/17/medline PY - 2008/7/1/entrez SP - 501 EP - 11 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 90 IS - 4 N2 - In the last 25 years data has grown exponentially dealing with the discovery of the endocannabinoid system consisting of specific cannabinoid receptors, their endogenous ligands, and enzymatic systems of their biosynthesis and degradation. Progress is being made in the development of novel agonists and antagonists with receptor subtype selectivity which should help in providing a greater understanding of the physiological role of the endocannabinoid system and perhaps also in a broad number of pathologies. This could lead to advances with important therapeutic potential of drugs modulating activity of endocannabinoid system as hypnotics, analgesics, antiemetics, antiasthmatics, antihypertensives, immunomodulatory drugs, antiphlogistics, neuroprotective agents, antiepileptics, agents influencing glaucoma, spasticity and other "movement disorders", eating disorders, alcohol withdrawal, hepatic fibrosis, bone growth, and atherosclerosis. The aim of this review is to highlight distribution of the CB1 and CB2 receptor subtypes in the nervous system and functional involvement of their specific ligands. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/18584858/Cannabinoid_receptors_1_and_2__CB1_and_CB2__their_distribution_ligands_and_functional_involvement_in_nervous_system_structures__a_short_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(08)00174-3 DB - PRIME DP - Unbound Medicine ER -