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Triamcinolone acetonide in silicone-filled eyes as adjunctive treatment for proliferative vitreoretinopathy: a randomized clinical trial.
Ophthalmology. 2008 Nov; 115(11):1938-43.O

Abstract

OBJECTIVE

To evaluate the effect of adjunctive intraocular triamcinolone acetonide (TA) in silicone-filled eyes on outcomes of vitreoretinal surgery for proliferative vitreoretinopathy (PVR).

DESIGN

Prospective, randomized, controlled clinical trial.

PARTICIPANTS

Seventy-five eyes with rhegmatogenous retinal detachment and PVR grade C (posterior, anterior, or both) undergoing vitrectomy combined with silicone oil tamponade were included. Of these, 38 eyes were assigned randomly to the adjunctive treatment, whereas 37 eyes served as controls.

INTERVENTION

All eyes underwent pars plana vitrectomy, membrane peeling, and silicone oil exchange, with or without relaxing retinotomy or retinectomy. In the treatment group, 4 mg TA was injected into the silicone-filled vitreous cavity at the end of the procedure. Silicone oil was removed 3 months after surgery in eyes with attached retinas.

MAIN OUTCOME MEASURES

The primary outcome measure was retinal reattachment rate at 6 months. Secondary outcome measures included visual acuity, rate of recurrent PVR, reoperation rate, and rise of intraocular pressure.

RESULTS

Retinal reattachment without any reoperation was achieved in 32 eyes (84.2%) and 29 eyes (78.4%) in the adjunctive treatment and control groups, respectively, at 6 months (P = 0.5). No statistically significant difference was observed between the 2 groups in terms of any of the secondary outcome measures (P>0.05).

CONCLUSIONS

The outcomes of vitreoretinal surgery for established PVR are not improved significantly by adjunctive TA injection in silicone-filled eyes.

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Authors+Show Affiliations

Ahmadieh H
Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University, M.C., Tehran, Iran.
Feghhi M
No affiliation info available
Tabatabaei H
No affiliation info available
Shoeibi N
No affiliation info available
Ramezani A
No affiliation info available
Mohebbi MR
No affiliation info available

MeSH

Combined Modality TherapyFemaleHumansImmunosuppressive AgentsInjectionsIntraocular PressureMaleMiddle AgedProspective StudiesRetinal DetachmentSilicone OilsTriamcinolone AcetonideVitrectomyVitreoretinopathy, ProliferativeVitreous Body

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18584876

Citation

Ahmadieh, Hamid, et al. "Triamcinolone Acetonide in Silicone-filled Eyes as Adjunctive Treatment for Proliferative Vitreoretinopathy: a Randomized Clinical Trial." Ophthalmology, vol. 115, no. 11, 2008, pp. 1938-43.
Ahmadieh H, Feghhi M, Tabatabaei H, et al. Triamcinolone acetonide in silicone-filled eyes as adjunctive treatment for proliferative vitreoretinopathy: a randomized clinical trial. Ophthalmology. 2008;115(11):1938-43.
Ahmadieh, H., Feghhi, M., Tabatabaei, H., Shoeibi, N., Ramezani, A., & Mohebbi, M. R. (2008). Triamcinolone acetonide in silicone-filled eyes as adjunctive treatment for proliferative vitreoretinopathy: a randomized clinical trial. Ophthalmology, 115(11), 1938-43. https://doi.org/10.1016/j.ophtha.2008.05.016
Ahmadieh H, et al. Triamcinolone Acetonide in Silicone-filled Eyes as Adjunctive Treatment for Proliferative Vitreoretinopathy: a Randomized Clinical Trial. Ophthalmology. 2008;115(11):1938-43. PubMed PMID: 18584876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triamcinolone acetonide in silicone-filled eyes as adjunctive treatment for proliferative vitreoretinopathy: a randomized clinical trial. AU - Ahmadieh,Hamid, AU - Feghhi,Mostafa, AU - Tabatabaei,Homa, AU - Shoeibi,Nasser, AU - Ramezani,Alireza, AU - Mohebbi,Mohammad Reza, Y1 - 2008/06/26/ PY - 2008/02/13/received PY - 2008/04/26/revised PY - 2008/05/07/accepted PY - 2008/7/1/pubmed PY - 2008/12/31/medline PY - 2008/7/1/entrez SP - 1938 EP - 43 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 11 N2 - OBJECTIVE: To evaluate the effect of adjunctive intraocular triamcinolone acetonide (TA) in silicone-filled eyes on outcomes of vitreoretinal surgery for proliferative vitreoretinopathy (PVR). DESIGN: Prospective, randomized, controlled clinical trial. PARTICIPANTS: Seventy-five eyes with rhegmatogenous retinal detachment and PVR grade C (posterior, anterior, or both) undergoing vitrectomy combined with silicone oil tamponade were included. Of these, 38 eyes were assigned randomly to the adjunctive treatment, whereas 37 eyes served as controls. INTERVENTION: All eyes underwent pars plana vitrectomy, membrane peeling, and silicone oil exchange, with or without relaxing retinotomy or retinectomy. In the treatment group, 4 mg TA was injected into the silicone-filled vitreous cavity at the end of the procedure. Silicone oil was removed 3 months after surgery in eyes with attached retinas. MAIN OUTCOME MEASURES: The primary outcome measure was retinal reattachment rate at 6 months. Secondary outcome measures included visual acuity, rate of recurrent PVR, reoperation rate, and rise of intraocular pressure. RESULTS: Retinal reattachment without any reoperation was achieved in 32 eyes (84.2%) and 29 eyes (78.4%) in the adjunctive treatment and control groups, respectively, at 6 months (P = 0.5). No statistically significant difference was observed between the 2 groups in terms of any of the secondary outcome measures (P>0.05). CONCLUSIONS: The outcomes of vitreoretinal surgery for established PVR are not improved significantly by adjunctive TA injection in silicone-filled eyes. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/18584876/Triamcinolone_acetonide_in_silicone_filled_eyes_as_adjunctive_treatment_for_proliferative_vitreoretinopathy:_a_randomized_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(08)00454-5 DB - PRIME DP - Unbound Medicine ER -