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Inhibitions of mast cell-derived histamine release by different Flos Magnoliae species in rat peritoneal mast cells.
Phytomedicine. 2008 Oct; 15(10):808-14.P

Abstract

Flos Magnoliae (FM) is a commonly used Chinese medicinal herb for symptomatic relief of allergic rhinitis, sinusitis and headache. A number of FM species have been used as substitutes or adulterants for clinical application, although the differences in their pharmacological actions have not been reported. The present study investigated the effects of six identified FM species M. biondii, M. denudata, M. kobus, M. liliflora, M. sargentiana and M. sprengeri, as well as the marker compounds magnolin and fargesin on compound 48/80-induced histamine release in rat peritoneal mast cells (RPMC) in vitro. Ethanolic extracts of all FM species produced a concentration-dependent inhibition of compound 48/80-induced histamine release in RPMC. The rank order of the IC(50)s was M. biondii<M. kobus<M. liliflora<M. denudata<M. sprengeri<M. sargentiana. The marker compound magnolin, but not fargesin, only slightly inhibited the histamine release. The contents of magnolin and fargesin, determined by using RP-HPLC, varied significantly among these FM species. Magnolin was found in M. biondii, M. kobus and M. liliflora, but not in M. denudate, M. sprengeri and M. sargentiana, while fargesin was only found in M. biondii and M. kobus. These findings provide the first evidence of differences in pharmacological actions of different FM species on mast cell-derived histamine release in vitro. In addition, the marker compounds magnolin and fargesin may not play a major role in the observed pharmacological actions of FM species.

Authors+Show Affiliations

RMIT Chinese Medicine Research Group, School of Health Sciences, RMIT University, Victoria, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18585022

Citation

Shen, Y, et al. "Inhibitions of Mast Cell-derived Histamine Release By Different Flos Magnoliae Species in Rat Peritoneal Mast Cells." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 15, no. 10, 2008, pp. 808-14.
Shen Y, Pang EC, Xue CC, et al. Inhibitions of mast cell-derived histamine release by different Flos Magnoliae species in rat peritoneal mast cells. Phytomedicine. 2008;15(10):808-14.
Shen, Y., Pang, E. C., Xue, C. C., Zhao, Z. Z., Lin, J. G., & Li, C. G. (2008). Inhibitions of mast cell-derived histamine release by different Flos Magnoliae species in rat peritoneal mast cells. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 15(10), 808-14. https://doi.org/10.1016/j.phymed.2008.04.012
Shen Y, et al. Inhibitions of Mast Cell-derived Histamine Release By Different Flos Magnoliae Species in Rat Peritoneal Mast Cells. Phytomedicine. 2008;15(10):808-14. PubMed PMID: 18585022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitions of mast cell-derived histamine release by different Flos Magnoliae species in rat peritoneal mast cells. AU - Shen,Y, AU - Pang,E C K, AU - Xue,C C L, AU - Zhao,Z Z, AU - Lin,J G, AU - Li,C G, Y1 - 2008/06/26/ PY - 2008/01/25/received PY - 2008/02/21/revised PY - 2008/04/28/accepted PY - 2008/7/1/pubmed PY - 2009/1/7/medline PY - 2008/7/1/entrez SP - 808 EP - 14 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 15 IS - 10 N2 - Flos Magnoliae (FM) is a commonly used Chinese medicinal herb for symptomatic relief of allergic rhinitis, sinusitis and headache. A number of FM species have been used as substitutes or adulterants for clinical application, although the differences in their pharmacological actions have not been reported. The present study investigated the effects of six identified FM species M. biondii, M. denudata, M. kobus, M. liliflora, M. sargentiana and M. sprengeri, as well as the marker compounds magnolin and fargesin on compound 48/80-induced histamine release in rat peritoneal mast cells (RPMC) in vitro. Ethanolic extracts of all FM species produced a concentration-dependent inhibition of compound 48/80-induced histamine release in RPMC. The rank order of the IC(50)s was M. biondii<M. kobus<M. liliflora<M. denudata<M. sprengeri<M. sargentiana. The marker compound magnolin, but not fargesin, only slightly inhibited the histamine release. The contents of magnolin and fargesin, determined by using RP-HPLC, varied significantly among these FM species. Magnolin was found in M. biondii, M. kobus and M. liliflora, but not in M. denudate, M. sprengeri and M. sargentiana, while fargesin was only found in M. biondii and M. kobus. These findings provide the first evidence of differences in pharmacological actions of different FM species on mast cell-derived histamine release in vitro. In addition, the marker compounds magnolin and fargesin may not play a major role in the observed pharmacological actions of FM species. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/18585022/Inhibitions_of_mast_cell_derived_histamine_release_by_different_Flos_Magnoliae_species_in_rat_peritoneal_mast_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(08)00085-8 DB - PRIME DP - Unbound Medicine ER -