Tags

Type your tag names separated by a space and hit enter

T-type Ca2+ channel blockers suppress the growth of human cancer cells.
Bioorg Med Chem Lett. 2008 Jul 15; 18(14):3899-901.BM

Abstract

In order to further clarify the role of T-type Ca(2+) channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca(2+) channel blockers. As a result, KYS05090, a most potent T-type Ca(2+) channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca(2+) channel blocker presents new prospects for cancer treatment.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Heo JH
Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, Republic of Korea.
Seo HN
No affiliation info available
Choe YJ
No affiliation info available
Kim S
No affiliation info available
Oh CR
No affiliation info available
Kim YD
No affiliation info available
Rhim H
No affiliation info available
Choo DJ
No affiliation info available
Kim J
No affiliation info available
Lee JY
No affiliation info available

MeSH

AnimalsAntineoplastic AgentsCalcium Channel BlockersCalcium Channels, T-TypeCell Line, TumorCell ProliferationChemistry, PharmaceuticalDoxorubicinDrug DesignDrug Screening Assays, AntitumorHumansInhibitory Concentration 50MiceModels, ChemicalQuinazolines

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18585035

Citation

Heo, Jae Ho, et al. "T-type Ca2+ Channel Blockers Suppress the Growth of Human Cancer Cells." Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 14, 2008, pp. 3899-901.
Heo JH, Seo HN, Choe YJ, et al. T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorg Med Chem Lett. 2008;18(14):3899-901.
Heo, J. H., Seo, H. N., Choe, Y. J., Kim, S., Oh, C. R., Kim, Y. D., Rhim, H., Choo, D. J., Kim, J., & Lee, J. Y. (2008). T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorganic & Medicinal Chemistry Letters, 18(14), 3899-901. https://doi.org/10.1016/j.bmcl.2008.06.034
Heo JH, et al. T-type Ca2+ Channel Blockers Suppress the Growth of Human Cancer Cells. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. PubMed PMID: 18585035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - T-type Ca2+ channel blockers suppress the growth of human cancer cells. AU - Heo,Jae Ho, AU - Seo,Han Na, AU - Choe,Yun Jeong, AU - Kim,Sujin, AU - Oh,Chun Rim, AU - Kim,Young Deuk, AU - Rhim,Hyewhon, AU - Choo,Dong Joon, AU - Kim,Jungahn, AU - Lee,Jae Yeol, Y1 - 2008/06/14/ PY - 2008/05/20/received PY - 2008/06/06/revised PY - 2008/06/11/accepted PY - 2008/7/1/pubmed PY - 2008/11/18/medline PY - 2008/7/1/entrez SP - 3899 EP - 901 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 18 IS - 14 N2 - In order to further clarify the role of T-type Ca(2+) channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca(2+) channel blockers. As a result, KYS05090, a most potent T-type Ca(2+) channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca(2+) channel blocker presents new prospects for cancer treatment. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/18585035/T_type_Ca2+_channel_blockers_suppress_the_growth_of_human_cancer_cells_ DB - PRIME DP - Unbound Medicine ER -