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Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.
Brain Res. 2008 Jul 30; 1222:207-13.BR

Abstract

Loss of neurons in the hippocampus and other brain regions is, besides the occurrence of plaques and tangles, a neuropathological feature of Alzheimer's disease (AD). In recent years a plethora of transgenic mouse models overexpressing mutant amyloid precursor protein (APP) has been developed, which represent valuable research tools. Whereas extracellular plaque pathology is a common feature of these models, neuronal loss is a rather rare characteristic. In the present study, we quantified the number of neurons in the dentate gyrus granule layer (GCL) in 2- and 12-month-old APP/PS1KI mice, a mouse model that has been previously shown to have significant loss of neurons in the CA1 layer of the hippocampus. Stereological analysis revealed a strongly significant decrease of GCLs in aged APP/PS1KI mice, compared to age-matched PS1KI control animals (-44%), however, the volume of the GCL was not different.

Authors+Show Affiliations

Division of Molecular Psychiatry and Alzheimer Ph.D. Graduate School, Department of Psychiatry, University of Goettingen, von-Siebold-Strasse 5, Goettingen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18585693

Citation

Cotel, Marie-Caroline, et al. "Age-dependent Loss of Dentate Gyrus Granule Cells in APP/PS1KI Mice." Brain Research, vol. 1222, 2008, pp. 207-13.
Cotel MC, Bayer TA, Wirths O. Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice. Brain Res. 2008;1222:207-13.
Cotel, M. C., Bayer, T. A., & Wirths, O. (2008). Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice. Brain Research, 1222, 207-13. https://doi.org/10.1016/j.brainres.2008.05.052
Cotel MC, Bayer TA, Wirths O. Age-dependent Loss of Dentate Gyrus Granule Cells in APP/PS1KI Mice. Brain Res. 2008 Jul 30;1222:207-13. PubMed PMID: 18585693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice. AU - Cotel,Marie-Caroline, AU - Bayer,Thomas A, AU - Wirths,Oliver, Y1 - 2008/05/28/ PY - 2008/04/14/received PY - 2008/05/14/revised PY - 2008/05/17/accepted PY - 2008/7/1/pubmed PY - 2008/11/13/medline PY - 2008/7/1/entrez SP - 207 EP - 13 JF - Brain research JO - Brain Res. VL - 1222 N2 - Loss of neurons in the hippocampus and other brain regions is, besides the occurrence of plaques and tangles, a neuropathological feature of Alzheimer's disease (AD). In recent years a plethora of transgenic mouse models overexpressing mutant amyloid precursor protein (APP) has been developed, which represent valuable research tools. Whereas extracellular plaque pathology is a common feature of these models, neuronal loss is a rather rare characteristic. In the present study, we quantified the number of neurons in the dentate gyrus granule layer (GCL) in 2- and 12-month-old APP/PS1KI mice, a mouse model that has been previously shown to have significant loss of neurons in the CA1 layer of the hippocampus. Stereological analysis revealed a strongly significant decrease of GCLs in aged APP/PS1KI mice, compared to age-matched PS1KI control animals (-44%), however, the volume of the GCL was not different. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/18585693/Age_dependent_loss_of_dentate_gyrus_granule_cells_in_APP/PS1KI_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(08)01227-4 DB - PRIME DP - Unbound Medicine ER -