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Outcome of untethering for symptomatic spina bifida occulta with lumbosacral spinal cord tethering in 31 patients: analysis of preoperative prognostic factors.
Spine J. 2008 Jul-Aug; 8(4):630-8.SJ

Abstract

BACKGROUND CONTEXT

The most important goal for treating symptomatic lumbosacral spinal cord tethering is early untethering.

PURPOSE

To investigate preoperative symptoms that may have affected the outcome.

STUDY DESIGN

Patients with or without improvement and with or without favorable outcome after untethering were compared retrospectively by chart and image review.

PATIENT SAMPLE

Thirty-one patients (age between 2 days to 25 years) with spina bifida occulta and symptomatic cord tethering were analyzed. Presenting symptoms (neurological deficits, urological dysfunction, and lower limb deformities) were assessed before and after untethering.

OUTCOME MEASURES

Favorable outcome was defined as complete relief of symptoms or mild symptoms whereby patients are able to look after their own personal care without assistance. Unfavorable outcome was defined as moderate or severe disability whereby patients are unable to attend to their own bodily needs without assistance, are bedridden, or require constant nursing attention.

METHODS

Differences in patient characteristics and presenting symptoms were compared between those with and without clinical improvement and favorable outcome. Multivariate logistic regression was used to identify prognostic factors affecting the outcome.

RESULTS

The average age at surgery was 7.2 years, with a male-to-female ratio of 1.2. The average follow-up time was 4 years. At least one of the following symptoms was present in all patients: neurological deficits (83.9%), urological dysfunction (77.4%), or limb deformities (38.7%). After untethering, all patients had either symptoms stabilized (14 patients, 45.2%) or improved (17 patients, 54.8%), and 14 patients (45.2%) achieved total resolving of symptoms. Logistic regression confirmed that younger age (< or =2 years, odds ratio [OR] 22.0, p=.026), lipomas of filum terminale (OR 25.6, p=.042), and a poor anal tone (OR 10.4, p=.061) were positive prognostic factors for the improvement in symptoms. The functional outcome was determined by the age at surgery (OR 0.9 per year since 1 year old, p=.04) and the presence of limb deformities (OR 0.06, p=.017).

CONCLUSIONS

In conclusion, our study suggests that untethering should be performed immediately once the patient shows evidence of symptomatic lumbosacral cord tethering, irrespective of age. Untethering can interrupt progression of symptoms, but sphincter dysfunction and muscle weakness are more likely to improve or resolve. Benefits can be seen in all patients, but young children (before 2 years old) have a higher chance to gain favorable outcome. Retethering is a main concern during follow-up, particularly for the more complicated lipomyelomeningoceles. Investigations using electrophysiologic and urodynamic studies are helpful for early detection of subtle symptomatic cord tethering or retethering.

Authors+Show Affiliations

Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18586199

Citation

Tseng, Jen-Ho, et al. "Outcome of Untethering for Symptomatic Spina Bifida Occulta With Lumbosacral Spinal Cord Tethering in 31 Patients: Analysis of Preoperative Prognostic Factors." The Spine Journal : Official Journal of the North American Spine Society, vol. 8, no. 4, 2008, pp. 630-8.
Tseng JH, Kuo MF, Kwang Tu Y, et al. Outcome of untethering for symptomatic spina bifida occulta with lumbosacral spinal cord tethering in 31 patients: analysis of preoperative prognostic factors. Spine J. 2008;8(4):630-8.
Tseng, J. H., Kuo, M. F., Kwang Tu, Y., & Tseng, M. Y. (2008). Outcome of untethering for symptomatic spina bifida occulta with lumbosacral spinal cord tethering in 31 patients: analysis of preoperative prognostic factors. The Spine Journal : Official Journal of the North American Spine Society, 8(4), 630-8. https://doi.org/10.1016/j.spinee.2005.11.005
Tseng JH, et al. Outcome of Untethering for Symptomatic Spina Bifida Occulta With Lumbosacral Spinal Cord Tethering in 31 Patients: Analysis of Preoperative Prognostic Factors. Spine J. 2008 Jul-Aug;8(4):630-8. PubMed PMID: 18586199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcome of untethering for symptomatic spina bifida occulta with lumbosacral spinal cord tethering in 31 patients: analysis of preoperative prognostic factors. AU - Tseng,Jen-Ho, AU - Kuo,Meng-Fai, AU - Kwang Tu,Yong, AU - Tseng,Ming-Yuan, Y1 - 2006/07/11/ PY - 2005/08/06/received PY - 2005/10/26/revised PY - 2005/11/17/accepted PY - 2008/7/1/pubmed PY - 2008/9/5/medline PY - 2008/7/1/entrez SP - 630 EP - 8 JF - The spine journal : official journal of the North American Spine Society JO - Spine J VL - 8 IS - 4 N2 - BACKGROUND CONTEXT: The most important goal for treating symptomatic lumbosacral spinal cord tethering is early untethering. PURPOSE: To investigate preoperative symptoms that may have affected the outcome. STUDY DESIGN: Patients with or without improvement and with or without favorable outcome after untethering were compared retrospectively by chart and image review. PATIENT SAMPLE: Thirty-one patients (age between 2 days to 25 years) with spina bifida occulta and symptomatic cord tethering were analyzed. Presenting symptoms (neurological deficits, urological dysfunction, and lower limb deformities) were assessed before and after untethering. OUTCOME MEASURES: Favorable outcome was defined as complete relief of symptoms or mild symptoms whereby patients are able to look after their own personal care without assistance. Unfavorable outcome was defined as moderate or severe disability whereby patients are unable to attend to their own bodily needs without assistance, are bedridden, or require constant nursing attention. METHODS: Differences in patient characteristics and presenting symptoms were compared between those with and without clinical improvement and favorable outcome. Multivariate logistic regression was used to identify prognostic factors affecting the outcome. RESULTS: The average age at surgery was 7.2 years, with a male-to-female ratio of 1.2. The average follow-up time was 4 years. At least one of the following symptoms was present in all patients: neurological deficits (83.9%), urological dysfunction (77.4%), or limb deformities (38.7%). After untethering, all patients had either symptoms stabilized (14 patients, 45.2%) or improved (17 patients, 54.8%), and 14 patients (45.2%) achieved total resolving of symptoms. Logistic regression confirmed that younger age (< or =2 years, odds ratio [OR] 22.0, p=.026), lipomas of filum terminale (OR 25.6, p=.042), and a poor anal tone (OR 10.4, p=.061) were positive prognostic factors for the improvement in symptoms. The functional outcome was determined by the age at surgery (OR 0.9 per year since 1 year old, p=.04) and the presence of limb deformities (OR 0.06, p=.017). CONCLUSIONS: In conclusion, our study suggests that untethering should be performed immediately once the patient shows evidence of symptomatic lumbosacral cord tethering, irrespective of age. Untethering can interrupt progression of symptoms, but sphincter dysfunction and muscle weakness are more likely to improve or resolve. Benefits can be seen in all patients, but young children (before 2 years old) have a higher chance to gain favorable outcome. Retethering is a main concern during follow-up, particularly for the more complicated lipomyelomeningoceles. Investigations using electrophysiologic and urodynamic studies are helpful for early detection of subtle symptomatic cord tethering or retethering. SN - 1529-9430 UR - https://www.unboundmedicine.com/medline/citation/18586199/Outcome_of_untethering_for_symptomatic_spina_bifida_occulta_with_lumbosacral_spinal_cord_tethering_in_31_patients:_analysis_of_preoperative_prognostic_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1529-9430(05)01062-4 DB - PRIME DP - Unbound Medicine ER -