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Joint association of magnesium and iron intake with anemia among Chinese adults.
Nutrition. 2008 Oct; 24(10):977-84.N

Abstract

OBJECTIVE

Inflammation and iron deficiency are two important causes of anemia. Magnesium intake is inversely associated with inflammation. However, little is known as to whether magnesium intake is related to anemia. We assessed the joint association of magnesium and iron intake with anemia among Chinese adults.

METHODS

A cross-sectional household survey of 2849 men and women 20 y of age or older was conducted in 2002. Nutrient intakes were assessed by 3-d weighed food records. Serum ferritin and hemoglobin concentrations were measured.

RESULTS

The prevalence of anemia was 18.3% in men and 31.5% in women. Magnesium and iron intakes were positively associated with hemoglobin levels and inversely related to the prevalence of anemia. The risks of anemia were reduced by 26% (P for trend = 0.03) and 52% (P < 0.01), respectively, for iron and magnesium intake comparing the fourth quartile with the first with adjustment for potential confounders. The lowest risk of anemia was observed among participants with the highest intakes of magnesium and iron (odds ratio 0.46, 95% confidence interval 0.31-0.68). The inverse association of iron intake and anemia but not the association of magnesium intake and anemia was modified by serum ferritin levels. The observed relations were not appreciably modified by gender.

CONCLUSION

This study suggests that magnesium is a potent predictor of anemia in Chinese adults.

Authors+Show Affiliations

Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China. zumins@vip.sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18586459

Citation

Shi, Zumin, et al. "Joint Association of Magnesium and Iron Intake With Anemia Among Chinese Adults." Nutrition (Burbank, Los Angeles County, Calif.), vol. 24, no. 10, 2008, pp. 977-84.
Shi Z, Hu X, He K, et al. Joint association of magnesium and iron intake with anemia among Chinese adults. Nutrition. 2008;24(10):977-84.
Shi, Z., Hu, X., He, K., Yuan, B., & Garg, M. (2008). Joint association of magnesium and iron intake with anemia among Chinese adults. Nutrition (Burbank, Los Angeles County, Calif.), 24(10), 977-84. https://doi.org/10.1016/j.nut.2008.05.002
Shi Z, et al. Joint Association of Magnesium and Iron Intake With Anemia Among Chinese Adults. Nutrition. 2008;24(10):977-84. PubMed PMID: 18586459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Joint association of magnesium and iron intake with anemia among Chinese adults. AU - Shi,Zumin, AU - Hu,Xiaoshu, AU - He,Ka, AU - Yuan,Baojun, AU - Garg,Manohar, Y1 - 2008/06/30/ PY - 2008/01/08/received PY - 2008/04/28/revised PY - 2008/05/09/accepted PY - 2008/7/1/pubmed PY - 2009/2/5/medline PY - 2008/7/1/entrez SP - 977 EP - 84 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 24 IS - 10 N2 - OBJECTIVE: Inflammation and iron deficiency are two important causes of anemia. Magnesium intake is inversely associated with inflammation. However, little is known as to whether magnesium intake is related to anemia. We assessed the joint association of magnesium and iron intake with anemia among Chinese adults. METHODS: A cross-sectional household survey of 2849 men and women 20 y of age or older was conducted in 2002. Nutrient intakes were assessed by 3-d weighed food records. Serum ferritin and hemoglobin concentrations were measured. RESULTS: The prevalence of anemia was 18.3% in men and 31.5% in women. Magnesium and iron intakes were positively associated with hemoglobin levels and inversely related to the prevalence of anemia. The risks of anemia were reduced by 26% (P for trend = 0.03) and 52% (P < 0.01), respectively, for iron and magnesium intake comparing the fourth quartile with the first with adjustment for potential confounders. The lowest risk of anemia was observed among participants with the highest intakes of magnesium and iron (odds ratio 0.46, 95% confidence interval 0.31-0.68). The inverse association of iron intake and anemia but not the association of magnesium intake and anemia was modified by serum ferritin levels. The observed relations were not appreciably modified by gender. CONCLUSION: This study suggests that magnesium is a potent predictor of anemia in Chinese adults. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/18586459/Joint_association_of_magnesium_and_iron_intake_with_anemia_among_Chinese_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(08)00212-8 DB - PRIME DP - Unbound Medicine ER -