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Supplementation with zinc between meals has no effect on subsequent iron absorption or on iron status of Chilean women.
Nutrition. 2008 Oct; 24(10):957-63.N

Abstract

OBJECTIVE

Studies on the effect of zinc (Zn) supplementation on iron absorption and iron status have shown mixed results. We investigated the effect of daily supplementation with 20 mg of Zn for a period of 2 mo on iron absorption and iron status of Chilean women.

METHODS

Forty-four non-anemic, clinically healthy women 35 to 45 y of age were randomly selected to receive daily 20 mg of Zn, as Zn sulfate, or a placebo between meals for a period of 2 mo. Iron and zinc biochemical indicators and iron absorption studies were assessed at baseline and at the end of the study. Iron absorption was measured using the double radioisotopic technique.

RESULTS

The geometric mean (range +/- 1 standard deviation) absorption of iron before supplementation between the Zn-supplemented and placebo groups was similar (31.2, 11.2 +/- 86.3, versus 27.4, 14.4 +/- 52.2, respectively, P = 0.97). Absorption increased significantly after the 2-mo supplementation period (P = 0.049), but there were no group-wise differences at the end of the trial (34.4, 17.5 +/- 67.3, versus 39.8, 20.9 +/- 75.8, respectively, P = 0.97). The geometric mean plasma Zn concentrations did not change significantly in either group during the course of the study (P = 0.47). There was no significant effect of Zn supplementation on any of the iron indicators studied.

CONCLUSION

Supplementation of 20 mg of Zn between meals for a period of 2 mo had no effect on subsequent iron absorption or iron status of Chilean women.

Authors+Show Affiliations

Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile. dromana@inta.clNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18586462

Citation

Lopez de Romaña, Daniel, et al. "Supplementation With Zinc Between Meals Has No Effect On Subsequent Iron Absorption or On Iron Status of Chilean Women." Nutrition (Burbank, Los Angeles County, Calif.), vol. 24, no. 10, 2008, pp. 957-63.
Lopez de Romaña D, Ruz M, Pizarro F, et al. Supplementation with zinc between meals has no effect on subsequent iron absorption or on iron status of Chilean women. Nutrition. 2008;24(10):957-63.
Lopez de Romaña, D., Ruz, M., Pizarro, F., Landeta, L., & Olivares, M. A. (2008). Supplementation with zinc between meals has no effect on subsequent iron absorption or on iron status of Chilean women. Nutrition (Burbank, Los Angeles County, Calif.), 24(10), 957-63. https://doi.org/10.1016/j.nut.2008.04.007
Lopez de Romaña D, et al. Supplementation With Zinc Between Meals Has No Effect On Subsequent Iron Absorption or On Iron Status of Chilean Women. Nutrition. 2008;24(10):957-63. PubMed PMID: 18586462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation with zinc between meals has no effect on subsequent iron absorption or on iron status of Chilean women. AU - Lopez de Romaña,Daniel, AU - Ruz,Manuel, AU - Pizarro,Fernando, AU - Landeta,Leslie, AU - Olivares,Manuel A, Y1 - 2008/06/30/ PY - 2007/12/12/received PY - 2008/03/20/revised PY - 2008/04/08/accepted PY - 2008/7/1/pubmed PY - 2009/2/5/medline PY - 2008/7/1/entrez SP - 957 EP - 63 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 24 IS - 10 N2 - OBJECTIVE: Studies on the effect of zinc (Zn) supplementation on iron absorption and iron status have shown mixed results. We investigated the effect of daily supplementation with 20 mg of Zn for a period of 2 mo on iron absorption and iron status of Chilean women. METHODS: Forty-four non-anemic, clinically healthy women 35 to 45 y of age were randomly selected to receive daily 20 mg of Zn, as Zn sulfate, or a placebo between meals for a period of 2 mo. Iron and zinc biochemical indicators and iron absorption studies were assessed at baseline and at the end of the study. Iron absorption was measured using the double radioisotopic technique. RESULTS: The geometric mean (range +/- 1 standard deviation) absorption of iron before supplementation between the Zn-supplemented and placebo groups was similar (31.2, 11.2 +/- 86.3, versus 27.4, 14.4 +/- 52.2, respectively, P = 0.97). Absorption increased significantly after the 2-mo supplementation period (P = 0.049), but there were no group-wise differences at the end of the trial (34.4, 17.5 +/- 67.3, versus 39.8, 20.9 +/- 75.8, respectively, P = 0.97). The geometric mean plasma Zn concentrations did not change significantly in either group during the course of the study (P = 0.47). There was no significant effect of Zn supplementation on any of the iron indicators studied. CONCLUSION: Supplementation of 20 mg of Zn between meals for a period of 2 mo had no effect on subsequent iron absorption or iron status of Chilean women. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/18586462/Supplementation_with_zinc_between_meals_has_no_effect_on_subsequent_iron_absorption_or_on_iron_status_of_Chilean_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(08)00208-6 DB - PRIME DP - Unbound Medicine ER -