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High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes.
Asia Pac J Clin Nutr 2008; 17(2):330-8AP

Abstract

Hyperhomocysteinemia is an independent risk factor for coronary artery disease (CAD). The aim of this study was to investigate the relations between the methylenetetrafolate reductase (MTHFR) 677C-->T genotypes, B-vitamins (folate, vitamin B-12 and B-6), homocysteine and the risk of CAD. In this case-control study, patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery were assigned to the case group (n=121). Healthy individuals with normal blood biochemical values were assigned to the control group (n=155). Healthy subjects were matched to case subjects for age. The concentrations of plasma homocysteine, serum folate, vitamin B-12, plasma pyridoxal 5'- phosphate (PLP) and MTHFR 677C-->T gene polymorphism were obtained. The T-allele carriers had significantly higher plasma homocysteine concentration compared to subjects with the 677CC genotype. The MTHFR 677C-->T genotypes were associated with plasma homocysteine after adjusting for various potential risk factors in the case and pooled groups. The MTHFR genotypes were found to have no associations with the risk of CAD. However, plasma homocysteine (>or= 12.5 micromol/L) (OR, 3.49; 95% CI, 1.23-9.88) had a significant association with increased risk of CAD even after additionally adjusted folate status. High plasma homocysteine concentration had a direct effect on the risk of CAD independent of MTHFR 677C-->T genotypes.

Authors+Show Affiliations

Department of Nutrition and Health Sciences, Chung Chou Institiute of Technology, Changhwa, Taiwan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18586656

Citation

Lin, Ping-Ting, et al. "High Plasma Homocysteine Is Associated With the Risk of Coronary Artery Disease Independent of Methylenetetrahydrofolate Reductase 677C-->T Genotypes." Asia Pacific Journal of Clinical Nutrition, vol. 17, no. 2, 2008, pp. 330-8.
Lin PT, Huang MC, Lee BJ, et al. High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes. Asia Pac J Clin Nutr. 2008;17(2):330-8.
Lin, P. T., Huang, M. C., Lee, B. J., Cheng, C. H., Tsai, T. P., & Huang, Y. C. (2008). High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes. Asia Pacific Journal of Clinical Nutrition, 17(2), pp. 330-8.
Lin PT, et al. High Plasma Homocysteine Is Associated With the Risk of Coronary Artery Disease Independent of Methylenetetrahydrofolate Reductase 677C-->T Genotypes. Asia Pac J Clin Nutr. 2008;17(2):330-8. PubMed PMID: 18586656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes. AU - Lin,Ping-Ting, AU - Huang,Men-Chung, AU - Lee,Bor-Jen, AU - Cheng,Chien-Hsiung, AU - Tsai,Tsung-Po, AU - Huang,Yi-Chia, PY - 2008/7/1/pubmed PY - 2009/1/13/medline PY - 2008/7/1/entrez SP - 330 EP - 8 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 17 IS - 2 N2 - Hyperhomocysteinemia is an independent risk factor for coronary artery disease (CAD). The aim of this study was to investigate the relations between the methylenetetrafolate reductase (MTHFR) 677C-->T genotypes, B-vitamins (folate, vitamin B-12 and B-6), homocysteine and the risk of CAD. In this case-control study, patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery were assigned to the case group (n=121). Healthy individuals with normal blood biochemical values were assigned to the control group (n=155). Healthy subjects were matched to case subjects for age. The concentrations of plasma homocysteine, serum folate, vitamin B-12, plasma pyridoxal 5'- phosphate (PLP) and MTHFR 677C-->T gene polymorphism were obtained. The T-allele carriers had significantly higher plasma homocysteine concentration compared to subjects with the 677CC genotype. The MTHFR 677C-->T genotypes were associated with plasma homocysteine after adjusting for various potential risk factors in the case and pooled groups. The MTHFR genotypes were found to have no associations with the risk of CAD. However, plasma homocysteine (>or= 12.5 micromol/L) (OR, 3.49; 95% CI, 1.23-9.88) had a significant association with increased risk of CAD even after additionally adjusted folate status. High plasma homocysteine concentration had a direct effect on the risk of CAD independent of MTHFR 677C-->T genotypes. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/18586656/High_plasma_homocysteine_is_associated_with_the_risk_of_coronary_artery_disease_independent_of_methylenetetrahydrofolate_reductase_677C__>T_genotypes_ L2 - http://apjcn.nhri.org.tw/server/APJCN/17/2/330.pdf DB - PRIME DP - Unbound Medicine ER -