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Duration of untreated psychosis and it's effect on the functional outcome in schizophrenia - preliminary results.
Psychiatr Danub. 2008 Jun; 20(2):179-83.PD

Abstract

OBJECTIVES

A long duration of untreated psychosis (DUP) is associated with a poorer prognosis and with worse functional outcome. The aim of the study was to show that early treatment with antipsychotics in the prodromal phase improves the outcome; to compare outcome in patients with DUP longer than 1 year (group 1) with patients who had received treatment with antipsychotic medication in the prodromal phase of the disease (group 0).

SUBJECTS AND METHODS

87 patients with schizophrenia were included in the retrospective study, 37 patients in group 0 and 50 patients in group 1. Sociodemographic parameters were evaluated, including employment, marital status and educational level. Groups were compared during the acute psychosis of first episode (t1) and at the conclusion of the study (t2).

RESULTS

Vocational status was worse in group 1 with a higher degree of unemployment and disability than in group 0 (chi(2)=17.47, df=4, p=0.002) at t2. More than half of the patients in group 1 were on disability benefit as compared to 19% of patients in group 0. At t1 differences were not statistically significant (chi(2)=4.15, df=3, p=0.245). There were more single patients in group 1 during both evaluations. At t1 almost half of the patients in group 0 were married; in group 1 only 18% were married (chi(2)=11.47, df=3, p=0.003). Also at t2 more patients in group 0 were married than in group 1 (chi(2)=8.01, df=3, p=0.046). Significant differences between the groups in achieved educational level were noted only at t1 (chi(2)=9.65, df=3, p=0.022).

CONCLUSIONS

Better outcome can be achieved with early antipsychotic treatment in the prodromal phase.

Authors+Show Affiliations

University Psychiatric Hospital Ljubljana, Studenec 48, 1260 Ljubljana, Slovenia. brigita.novak@psih-klinika.siNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18587288

Citation

Sarotar, Brigita Novak, et al. "Duration of Untreated Psychosis and It's Effect On the Functional Outcome in Schizophrenia - Preliminary Results." Psychiatria Danubina, vol. 20, no. 2, 2008, pp. 179-83.
Sarotar BN, Pesek MB, Agius M, et al. Duration of untreated psychosis and it's effect on the functional outcome in schizophrenia - preliminary results. Psychiatr Danub. 2008;20(2):179-83.
Sarotar, B. N., Pesek, M. B., Agius, M., Pregelj, P., & Kocmur, M. (2008). Duration of untreated psychosis and it's effect on the functional outcome in schizophrenia - preliminary results. Psychiatria Danubina, 20(2), 179-83.
Sarotar BN, et al. Duration of Untreated Psychosis and It's Effect On the Functional Outcome in Schizophrenia - Preliminary Results. Psychiatr Danub. 2008;20(2):179-83. PubMed PMID: 18587288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of untreated psychosis and it's effect on the functional outcome in schizophrenia - preliminary results. AU - Sarotar,Brigita Novak, AU - Pesek,Marjeta Blinc, AU - Agius,Mark, AU - Pregelj,Peter, AU - Kocmur,Marga, PY - 2008/7/1/pubmed PY - 2008/9/27/medline PY - 2008/7/1/entrez SP - 179 EP - 83 JF - Psychiatria Danubina JO - Psychiatr Danub VL - 20 IS - 2 N2 - OBJECTIVES: A long duration of untreated psychosis (DUP) is associated with a poorer prognosis and with worse functional outcome. The aim of the study was to show that early treatment with antipsychotics in the prodromal phase improves the outcome; to compare outcome in patients with DUP longer than 1 year (group 1) with patients who had received treatment with antipsychotic medication in the prodromal phase of the disease (group 0). SUBJECTS AND METHODS: 87 patients with schizophrenia were included in the retrospective study, 37 patients in group 0 and 50 patients in group 1. Sociodemographic parameters were evaluated, including employment, marital status and educational level. Groups were compared during the acute psychosis of first episode (t1) and at the conclusion of the study (t2). RESULTS: Vocational status was worse in group 1 with a higher degree of unemployment and disability than in group 0 (chi(2)=17.47, df=4, p=0.002) at t2. More than half of the patients in group 1 were on disability benefit as compared to 19% of patients in group 0. At t1 differences were not statistically significant (chi(2)=4.15, df=3, p=0.245). There were more single patients in group 1 during both evaluations. At t1 almost half of the patients in group 0 were married; in group 1 only 18% were married (chi(2)=11.47, df=3, p=0.003). Also at t2 more patients in group 0 were married than in group 1 (chi(2)=8.01, df=3, p=0.046). Significant differences between the groups in achieved educational level were noted only at t1 (chi(2)=9.65, df=3, p=0.022). CONCLUSIONS: Better outcome can be achieved with early antipsychotic treatment in the prodromal phase. SN - 0353-5053 UR - https://www.unboundmedicine.com/medline/citation/18587288/Duration_of_untreated_psychosis_and_it's_effect_on_the_functional_outcome_in_schizophrenia___preliminary_results_ L2 - http://www.diseaseinfosearch.org/result/6442 DB - PRIME DP - Unbound Medicine ER -