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Uric acid and nocturnal nondipping in hypertensive patients with normal renal function.
J Nephrol. 2008 May-Jun; 21(3):406-11.JN

Abstract

BACKGROUND

The effect of uric acid on nocturnal dipping in hypertensive patients is unknown. We analyzed the specific relationship between uric acid and nocturnal dipping status in newly diagnosed essential hypertensive patients with normal renal function.

METHODS

Two hundred fifteen patients with newly diagnosed essential hypertension underwent 24-hour ambulatory blood pressure monitoring, biochemistry analysis and 24-hour urine testing.

RESULTS

Patients were classified as either dippers (157 patients) or nondippers (58 patients). Uric acid levels were higher in nondippers than in dippers (345.0 +/- 65.4 mmol/L vs. 270.6 +/- 59.5 mmol/L, p<0.0001) and positively correlated with the following blood pressure (BP) values: average nighttime ambulatory systolic BP (r=0.325, p<0.0001), average nighttime ambulatory diastolic BP (r=0.203, p=0.003), nighttime mean arterial BP (r=0.285, p<0.0001) and mean 24-hour arterial BP (r=0.197, p=0.004). Uric acid was also positively correlated with nighttime heart rate (r=0.293, p=0.001). Univariate logistic regression analysis showed that a high serum uric acid level (odds ratio [OR] = 3.566; 95% confidence interval [95% CI], 2.397-5.303; p<0.0001) and smoking (OR=2.294; 95% CI, 1.155-4.498; p=0.018) increased the risk of nocturnal nondipping. The results of multivariate analysis showed that serum uric acid levels (OR=3.453; 95% CI, 1.466-8.134; p=0.005) together with fasting blood glucose (OR=1.148; 95% CI, 1.028-1.281; p=0.014) were associated with the nondipping pattern.

CONCLUSIONS

This study is the first to demonstrate that increased serum uric acid levels are associated with nondipping blood pressure patterns in patients with essential hypertension.

Authors+Show Affiliations

Afsar B
Department of Nephrology, Baskent University Hospital, Ankara, Turkey. afsarbrs@yahoo.com
Elsurer R
No affiliation info available
Ozdemir FN
No affiliation info available
Sezer S
No affiliation info available

MeSH

Blood GlucoseBlood PressureBlood Pressure Monitoring, AmbulatoryCircadian RhythmFemaleGlomerular Filtration RateHumansHypertensionKidney Function TestsMaleMiddle AgedUric Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18587730

Citation

Afsar, Baris, et al. "Uric Acid and Nocturnal Nondipping in Hypertensive Patients With Normal Renal Function." Journal of Nephrology, vol. 21, no. 3, 2008, pp. 406-11.
Afsar B, Elsurer R, Ozdemir FN, et al. Uric acid and nocturnal nondipping in hypertensive patients with normal renal function. J Nephrol. 2008;21(3):406-11.
Afsar, B., Elsurer, R., Ozdemir, F. N., & Sezer, S. (2008). Uric acid and nocturnal nondipping in hypertensive patients with normal renal function. Journal of Nephrology, 21(3), 406-11.
Afsar B, et al. Uric Acid and Nocturnal Nondipping in Hypertensive Patients With Normal Renal Function. J Nephrol. 2008 May-Jun;21(3):406-11. PubMed PMID: 18587730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uric acid and nocturnal nondipping in hypertensive patients with normal renal function. AU - Afsar,Baris, AU - Elsurer,Rengin, AU - Ozdemir,Fatima Nurhan, AU - Sezer,Siren, PY - 2008/7/1/pubmed PY - 2008/9/18/medline PY - 2008/7/1/entrez SP - 406 EP - 11 JF - Journal of nephrology JO - J Nephrol VL - 21 IS - 3 N2 - BACKGROUND: The effect of uric acid on nocturnal dipping in hypertensive patients is unknown. We analyzed the specific relationship between uric acid and nocturnal dipping status in newly diagnosed essential hypertensive patients with normal renal function. METHODS: Two hundred fifteen patients with newly diagnosed essential hypertension underwent 24-hour ambulatory blood pressure monitoring, biochemistry analysis and 24-hour urine testing. RESULTS: Patients were classified as either dippers (157 patients) or nondippers (58 patients). Uric acid levels were higher in nondippers than in dippers (345.0 +/- 65.4 mmol/L vs. 270.6 +/- 59.5 mmol/L, p<0.0001) and positively correlated with the following blood pressure (BP) values: average nighttime ambulatory systolic BP (r=0.325, p<0.0001), average nighttime ambulatory diastolic BP (r=0.203, p=0.003), nighttime mean arterial BP (r=0.285, p<0.0001) and mean 24-hour arterial BP (r=0.197, p=0.004). Uric acid was also positively correlated with nighttime heart rate (r=0.293, p=0.001). Univariate logistic regression analysis showed that a high serum uric acid level (odds ratio [OR] = 3.566; 95% confidence interval [95% CI], 2.397-5.303; p<0.0001) and smoking (OR=2.294; 95% CI, 1.155-4.498; p=0.018) increased the risk of nocturnal nondipping. The results of multivariate analysis showed that serum uric acid levels (OR=3.453; 95% CI, 1.466-8.134; p=0.005) together with fasting blood glucose (OR=1.148; 95% CI, 1.028-1.281; p=0.014) were associated with the nondipping pattern. CONCLUSIONS: This study is the first to demonstrate that increased serum uric acid levels are associated with nondipping blood pressure patterns in patients with essential hypertension. SN - 1121-8428 UR - https://www.unboundmedicine.com/medline/citation/18587730/Uric_acid_and_nocturnal_nondipping_in_hypertensive_patients_with_normal_renal_function_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -