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Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation.
Eur J Neurosci. 2008 Jun; 27(11):2821-9.EJ

Abstract

Daily life stressors are a major environmental factor contributing to precipitation and exacerbation of mental illness. Animal models using repeated homotypic stress induce anxious and depressive phenotypes and are used to study the pathophysiology of affective disorders. Here we discuss data demonstrating that repeated homotypic stress produces temporally and anatomically distinct changes in endocannabinoid signaling components within stress-responsive brain regions. We also present evidence describing the neural and behavioral correlates of these adaptations in endocannabinoid signaling. These data support a role for endocannabinoid signaling in the central nervous system response to chronic, homotypic stress, and specifically in the process of stress-response habituation. The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed.

Authors+Show Affiliations

Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA. sachin.patel@vanderbilt.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18588527

Citation

Patel, Sachin, and Cecilia J. Hillard. "Adaptations in Endocannabinoid Signaling in Response to Repeated Homotypic Stress: a Novel Mechanism for Stress Habituation." The European Journal of Neuroscience, vol. 27, no. 11, 2008, pp. 2821-9.
Patel S, Hillard CJ. Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. Eur J Neurosci. 2008;27(11):2821-9.
Patel, S., & Hillard, C. J. (2008). Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. The European Journal of Neuroscience, 27(11), 2821-9. https://doi.org/10.1111/j.1460-9568.2008.06266.x
Patel S, Hillard CJ. Adaptations in Endocannabinoid Signaling in Response to Repeated Homotypic Stress: a Novel Mechanism for Stress Habituation. Eur J Neurosci. 2008;27(11):2821-9. PubMed PMID: 18588527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. AU - Patel,Sachin, AU - Hillard,Cecilia J, PY - 2008/7/1/pubmed PY - 2008/8/21/medline PY - 2008/7/1/entrez SP - 2821 EP - 9 JF - The European journal of neuroscience JO - Eur. J. Neurosci. VL - 27 IS - 11 N2 - Daily life stressors are a major environmental factor contributing to precipitation and exacerbation of mental illness. Animal models using repeated homotypic stress induce anxious and depressive phenotypes and are used to study the pathophysiology of affective disorders. Here we discuss data demonstrating that repeated homotypic stress produces temporally and anatomically distinct changes in endocannabinoid signaling components within stress-responsive brain regions. We also present evidence describing the neural and behavioral correlates of these adaptations in endocannabinoid signaling. These data support a role for endocannabinoid signaling in the central nervous system response to chronic, homotypic stress, and specifically in the process of stress-response habituation. The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed. SN - 1460-9568 UR - https://www.unboundmedicine.com/medline/citation/18588527/Adaptations_in_endocannabinoid_signaling_in_response_to_repeated_homotypic_stress:_a_novel_mechanism_for_stress_habituation_ L2 - https://doi.org/10.1111/j.1460-9568.2008.06266.x DB - PRIME DP - Unbound Medicine ER -