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Selenium and asthma: a complex relationship.
Allergy 2008; 63(7):854-6A

Abstract

Descriptive studies in humans investigating the relationship between selenium (Se) status and asthma have presented inconsistent results. The concept of low Se status as a potential risk factor for increased prevalence or severity of asthma is based on the role that Se, through its incorporation into selenoproteins, plays as a potent antioxidant capable of augmenting the oxidative stress that accompanies asthma. However, Se intake also exerts a significant influence over immune responses. Thus, the dual effects of Se status on controlling oxidative stress in the lungs and regulating T helper 2 responses that drive allergic asthma, as well as which selenoproteins are key to regulating these processes, must be considered when attempting to decipher the relationship between this essential nutrient and complex allergic diseases such as asthma.

Authors

No affiliation info available

Pub Type(s)

Comment
Editorial

Language

eng

PubMed ID

18588550

Citation

Hoffmann, P R.. "Selenium and Asthma: a Complex Relationship." Allergy, vol. 63, no. 7, 2008, pp. 854-6.
Hoffmann PR. Selenium and asthma: a complex relationship. Allergy. 2008;63(7):854-6.
Hoffmann, P. R. (2008). Selenium and asthma: a complex relationship. Allergy, 63(7), pp. 854-6. doi:10.1111/j.1398-9995.2008.01676.x.
Hoffmann PR. Selenium and Asthma: a Complex Relationship. Allergy. 2008;63(7):854-6. PubMed PMID: 18588550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium and asthma: a complex relationship. A1 - Hoffmann,P R, PY - 2008/7/1/pubmed PY - 2008/7/31/medline PY - 2008/7/1/entrez SP - 854 EP - 6 JF - Allergy JO - Allergy VL - 63 IS - 7 N2 - Descriptive studies in humans investigating the relationship between selenium (Se) status and asthma have presented inconsistent results. The concept of low Se status as a potential risk factor for increased prevalence or severity of asthma is based on the role that Se, through its incorporation into selenoproteins, plays as a potent antioxidant capable of augmenting the oxidative stress that accompanies asthma. However, Se intake also exerts a significant influence over immune responses. Thus, the dual effects of Se status on controlling oxidative stress in the lungs and regulating T helper 2 responses that drive allergic asthma, as well as which selenoproteins are key to regulating these processes, must be considered when attempting to decipher the relationship between this essential nutrient and complex allergic diseases such as asthma. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/18588550/Selenium_and_asthma:_a_complex_relationship_ L2 - https://doi.org/10.1111/j.1398-9995.2008.01676.x DB - PRIME DP - Unbound Medicine ER -