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ACE and MTHFR gene polymorphisms in unexplained recurrent pregnancy loss.
J Obstet Gynaecol Res 2008; 34(3):301-6JO

Abstract

AIM

To assess the association between polymorphisms in angiotensin converting enzyme and methylene tetrahydrofolate reductase genes and recurrent pregnancy loss by a case-control study in South Indian women.

METHODS

DNA was extracted from peripheral blood leukocytes of 104 women with Recurrent Pregnancy Loss (RPL) and 120 controls. Genotyping of ACE Insertion Deletion and MTHFR C677T polymorphism were carried out by PCR and PCR-RFLP, respectively.

RESULTS

No statistically significant difference was observed in the distribution of genotypes between cases and controls for ACE and MTHFR polymorphisms. Further, the combination of MTHFR and ACE genotypes failed to reveal an association.

CONCLUSION

In conclusion, the present study reveals lack of association of MTHFR C677T and ACE I/D polymorphisms in RPL in South Indian women. However, we cannot exclude the possibility that other polymorphisms of ACE and MTHFR genes could be associated with the disease and might be clinically useful as a marker to assess risk for RPL.

Authors+Show Affiliations

Department of Human Genetics, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18588608

Citation

Vettriselvi, Venkatesan, et al. "ACE and MTHFR Gene Polymorphisms in Unexplained Recurrent Pregnancy Loss." The Journal of Obstetrics and Gynaecology Research, vol. 34, no. 3, 2008, pp. 301-6.
Vettriselvi V, Vijayalakshmi K, Paul SF, et al. ACE and MTHFR gene polymorphisms in unexplained recurrent pregnancy loss. J Obstet Gynaecol Res. 2008;34(3):301-6.
Vettriselvi, V., Vijayalakshmi, K., Paul, S. F., & Venkatachalam, P. (2008). ACE and MTHFR gene polymorphisms in unexplained recurrent pregnancy loss. The Journal of Obstetrics and Gynaecology Research, 34(3), pp. 301-6. doi:10.1111/j.1447-0756.2008.00792.x.
Vettriselvi V, et al. ACE and MTHFR Gene Polymorphisms in Unexplained Recurrent Pregnancy Loss. J Obstet Gynaecol Res. 2008;34(3):301-6. PubMed PMID: 18588608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ACE and MTHFR gene polymorphisms in unexplained recurrent pregnancy loss. AU - Vettriselvi,Venkatesan, AU - Vijayalakshmi,Krishnaswami, AU - Paul,Solomon F D, AU - Venkatachalam,Perumal, PY - 2008/7/1/pubmed PY - 2008/9/5/medline PY - 2008/7/1/entrez SP - 301 EP - 6 JF - The journal of obstetrics and gynaecology research JO - J. Obstet. Gynaecol. Res. VL - 34 IS - 3 N2 - AIM: To assess the association between polymorphisms in angiotensin converting enzyme and methylene tetrahydrofolate reductase genes and recurrent pregnancy loss by a case-control study in South Indian women. METHODS: DNA was extracted from peripheral blood leukocytes of 104 women with Recurrent Pregnancy Loss (RPL) and 120 controls. Genotyping of ACE Insertion Deletion and MTHFR C677T polymorphism were carried out by PCR and PCR-RFLP, respectively. RESULTS: No statistically significant difference was observed in the distribution of genotypes between cases and controls for ACE and MTHFR polymorphisms. Further, the combination of MTHFR and ACE genotypes failed to reveal an association. CONCLUSION: In conclusion, the present study reveals lack of association of MTHFR C677T and ACE I/D polymorphisms in RPL in South Indian women. However, we cannot exclude the possibility that other polymorphisms of ACE and MTHFR genes could be associated with the disease and might be clinically useful as a marker to assess risk for RPL. SN - 1341-8076 UR - https://www.unboundmedicine.com/medline/citation/18588608/ACE_and_MTHFR_gene_polymorphisms_in_unexplained_recurrent_pregnancy_loss_ L2 - https://doi.org/10.1111/j.1447-0756.2008.00792.x DB - PRIME DP - Unbound Medicine ER -