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Granulocyte-colony stimulating factor producing rectal cancer.
World J Surg Oncol. 2008 Jun 29; 6:70.WJ

Abstract

BACKGROUND

Granulocyte-colony stimulating factor (G-CSF)-producing cancer has been reported to occur in various organs, especially the lung. However, G-CSF-producing colorectal cancer (CRC) has never been reported in the English literature.

CASE PRESENTATION

A 57-year-old man was admitted for the surgical removal of a rectal cancer. Some hepatic tumors in the liver were revealed concurrently, and their appearance suggested multiple liver metastases. Low anterior resection was performed. with the help of histopathological examination and immunohistochemical studies, we diagnosed this case to be an undifferentiated carcinoma of the rectum. After the operation, the white blood cell (WBC) count increased gradually to 81,000 cells/microL. Modified-FOLFOX6 therapy was initiated to treat the liver metastases, but there was no effect, and peritoneal dissemination had also occurred. The serum level of G-CSF was elevated to 840 pg/mL (normal range, <18.1 pg/mL). Furthermore, immunohistochemistry with a specific monoclonal antibody against G-CSF was positive; therefore, we diagnosed this tumor as a G-CSF-producing cancer. The patient died from rapid growth of the liver metastases and peritoneal dissemination 2 months after surgery.

CONCLUSION

This is the first case of G-CSF-producing rectal cancer, and its prognosis was very poor.

Authors+Show Affiliations

Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Japan. takahasi@med.nagoya-cu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18588705

Citation

Takahashi, Hiroki, et al. "Granulocyte-colony Stimulating Factor Producing Rectal Cancer." World Journal of Surgical Oncology, vol. 6, 2008, p. 70.
Takahashi H, Yasuda A, Ochi N, et al. Granulocyte-colony stimulating factor producing rectal cancer. World J Surg Oncol. 2008;6:70.
Takahashi, H., Yasuda, A., Ochi, N., Sakamoto, M., Takayama, S., Wakasugi, T., Funahashi, H., Sawai, H., Satoh, M., Akamo, Y., & Takeyama, H. (2008). Granulocyte-colony stimulating factor producing rectal cancer. World Journal of Surgical Oncology, 6, 70. https://doi.org/10.1186/1477-7819-6-70
Takahashi H, et al. Granulocyte-colony Stimulating Factor Producing Rectal Cancer. World J Surg Oncol. 2008 Jun 29;6:70. PubMed PMID: 18588705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Granulocyte-colony stimulating factor producing rectal cancer. AU - Takahashi,Hiroki, AU - Yasuda,Akira, AU - Ochi,Nubuo, AU - Sakamoto,Masaki, AU - Takayama,Satoru, AU - Wakasugi,Takehiro, AU - Funahashi,Hitoshi, AU - Sawai,Hirozumi, AU - Satoh,Mikinori, AU - Akamo,Yoshimi, AU - Takeyama,Hiromitsu, Y1 - 2008/06/29/ PY - 2008/03/31/received PY - 2008/06/29/accepted PY - 2008/7/1/pubmed PY - 2008/8/9/medline PY - 2008/7/1/entrez SP - 70 EP - 70 JF - World journal of surgical oncology JO - World J Surg Oncol VL - 6 N2 - BACKGROUND: Granulocyte-colony stimulating factor (G-CSF)-producing cancer has been reported to occur in various organs, especially the lung. However, G-CSF-producing colorectal cancer (CRC) has never been reported in the English literature. CASE PRESENTATION: A 57-year-old man was admitted for the surgical removal of a rectal cancer. Some hepatic tumors in the liver were revealed concurrently, and their appearance suggested multiple liver metastases. Low anterior resection was performed. with the help of histopathological examination and immunohistochemical studies, we diagnosed this case to be an undifferentiated carcinoma of the rectum. After the operation, the white blood cell (WBC) count increased gradually to 81,000 cells/microL. Modified-FOLFOX6 therapy was initiated to treat the liver metastases, but there was no effect, and peritoneal dissemination had also occurred. The serum level of G-CSF was elevated to 840 pg/mL (normal range, <18.1 pg/mL). Furthermore, immunohistochemistry with a specific monoclonal antibody against G-CSF was positive; therefore, we diagnosed this tumor as a G-CSF-producing cancer. The patient died from rapid growth of the liver metastases and peritoneal dissemination 2 months after surgery. CONCLUSION: This is the first case of G-CSF-producing rectal cancer, and its prognosis was very poor. SN - 1477-7819 UR - https://www.unboundmedicine.com/medline/citation/18588705/Granulocyte_colony_stimulating_factor_producing_rectal_cancer_ L2 - https://wjso.biomedcentral.com/articles/10.1186/1477-7819-6-70 DB - PRIME DP - Unbound Medicine ER -