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Dose-dependent antioxidant responses and pathological changes in tenca (Tinca tinca) after acute oral exposure to Microcystis under laboratory conditions.
Toxicon. 2008 Jul; 52(1):1-12.T

Abstract

The effects of cyanobacterial cells containing microcystins (MCs), toxins from cyanobacteria, on oxidative stress biomarkers from liver and kidney of Tenca fish (Tinca tinca) were investigated under laboratory conditions. Moreover, a histopathological study of liver, kidney, heart and intestine tissues was performed. Fish were orally exposed to cyanobacterial cells dosing 0, 5, 11, 25 and 55 microg MC-LR/fish mixed with the food. Results showed a dose-dependent decrease of superoxide dismutase (SOD) activity, and also of catalase (CAT) in the liver. Glutathione levels and protein oxidation, however, were not altered by the exposure to the cyanobacterial material. The microscopic study revealed tissue alterations even at the lower cyanobacterial cells doses. Onion-like hepatocytes in the liver, glomerulopathy in the kidney, loss of myofibrils in the heart and vacuolated enterocytes in the gastrointestinal tract were the main changes observed. These findings suggest that this fresh water fish can be adversely affected by cyanobacterial blooms in their natural habitats.

Authors+Show Affiliations

Area of Toxicology, Faculty of Pharmacy, University of Seville, Profesor García González 2, 41012 Seville, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18588906

Citation

Atencio, L, et al. "Dose-dependent Antioxidant Responses and Pathological Changes in Tenca (Tinca Tinca) After Acute Oral Exposure to Microcystis Under Laboratory Conditions." Toxicon : Official Journal of the International Society On Toxinology, vol. 52, no. 1, 2008, pp. 1-12.
Atencio L, Moreno I, Jos A, et al. Dose-dependent antioxidant responses and pathological changes in tenca (Tinca tinca) after acute oral exposure to Microcystis under laboratory conditions. Toxicon. 2008;52(1):1-12.
Atencio, L., Moreno, I., Jos, A., Pichardo, S., Moyano, R., Blanco, A., & Cameán, A. M. (2008). Dose-dependent antioxidant responses and pathological changes in tenca (Tinca tinca) after acute oral exposure to Microcystis under laboratory conditions. Toxicon : Official Journal of the International Society On Toxinology, 52(1), 1-12. https://doi.org/10.1016/j.toxicon.2008.05.009
Atencio L, et al. Dose-dependent Antioxidant Responses and Pathological Changes in Tenca (Tinca Tinca) After Acute Oral Exposure to Microcystis Under Laboratory Conditions. Toxicon. 2008;52(1):1-12. PubMed PMID: 18588906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose-dependent antioxidant responses and pathological changes in tenca (Tinca tinca) after acute oral exposure to Microcystis under laboratory conditions. AU - Atencio,L, AU - Moreno,I, AU - Jos,A, AU - Pichardo,S, AU - Moyano,R, AU - Blanco,A, AU - Cameán,A M, Y1 - 2008/07/18/ PY - 2008/03/12/received PY - 2008/05/20/revised PY - 2008/05/20/accepted PY - 2008/7/1/pubmed PY - 2008/9/17/medline PY - 2008/7/1/entrez SP - 1 EP - 12 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 52 IS - 1 N2 - The effects of cyanobacterial cells containing microcystins (MCs), toxins from cyanobacteria, on oxidative stress biomarkers from liver and kidney of Tenca fish (Tinca tinca) were investigated under laboratory conditions. Moreover, a histopathological study of liver, kidney, heart and intestine tissues was performed. Fish were orally exposed to cyanobacterial cells dosing 0, 5, 11, 25 and 55 microg MC-LR/fish mixed with the food. Results showed a dose-dependent decrease of superoxide dismutase (SOD) activity, and also of catalase (CAT) in the liver. Glutathione levels and protein oxidation, however, were not altered by the exposure to the cyanobacterial material. The microscopic study revealed tissue alterations even at the lower cyanobacterial cells doses. Onion-like hepatocytes in the liver, glomerulopathy in the kidney, loss of myofibrils in the heart and vacuolated enterocytes in the gastrointestinal tract were the main changes observed. These findings suggest that this fresh water fish can be adversely affected by cyanobacterial blooms in their natural habitats. SN - 0041-0101 UR - https://www.unboundmedicine.com/medline/citation/18588906/Dose_dependent_antioxidant_responses_and_pathological_changes_in_tenca__Tinca_tinca__after_acute_oral_exposure_to_Microcystis_under_laboratory_conditions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(08)00370-X DB - PRIME DP - Unbound Medicine ER -