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Celiac disease: from gluten to autoimmunity.
Autoimmun Rev 2008; 7(8):644-50AR

Abstract

Celiac disease, also known as gluten-sensitive enteropathy and nontropical sprue, is a prevalent autoimmune disorder that is triggered by the ingestion of wheat gluten and related proteins of rye and barley in genetically susceptible individuals. The immune response in celiac disease involves the adaptive, as well as the innate, and is characterized by the presence of anti-gluten and anti-transglutaminase 2 antibodies, lymphocytic infiltration in the epithelial membrane and the lamina propria, and expression of multiple cytokines and other signaling proteins. The disease leads to inflammation, villous atrophy, and crypt hyperplasia in the small intestine. In addition to the intestinal symptoms, celiac disease is associated with various extra-intestinal complications, including bone and skin disease, anemia, endocrine disorders, and neurologic deficits. Gluten-free diet is currently the only effective mode of treatment for celiac disease, but better understanding of the mechanism of the disease is likely to add other choices for therapy in the future.

Authors+Show Affiliations

Department of Neurosciences, University of Padova, Padova, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18589004

Citation

Briani, Chiara, et al. "Celiac Disease: From Gluten to Autoimmunity." Autoimmunity Reviews, vol. 7, no. 8, 2008, pp. 644-50.
Briani C, Samaroo D, Alaedini A. Celiac disease: from gluten to autoimmunity. Autoimmun Rev. 2008;7(8):644-50.
Briani, C., Samaroo, D., & Alaedini, A. (2008). Celiac disease: from gluten to autoimmunity. Autoimmunity Reviews, 7(8), pp. 644-50. doi:10.1016/j.autrev.2008.05.006.
Briani C, Samaroo D, Alaedini A. Celiac Disease: From Gluten to Autoimmunity. Autoimmun Rev. 2008;7(8):644-50. PubMed PMID: 18589004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Celiac disease: from gluten to autoimmunity. AU - Briani,Chiara, AU - Samaroo,Diana, AU - Alaedini,Armin, Y1 - 2008/06/25/ PY - 2008/05/02/received PY - 2008/05/20/accepted PY - 2008/7/1/pubmed PY - 2008/12/17/medline PY - 2008/7/1/entrez SP - 644 EP - 50 JF - Autoimmunity reviews JO - Autoimmun Rev VL - 7 IS - 8 N2 - Celiac disease, also known as gluten-sensitive enteropathy and nontropical sprue, is a prevalent autoimmune disorder that is triggered by the ingestion of wheat gluten and related proteins of rye and barley in genetically susceptible individuals. The immune response in celiac disease involves the adaptive, as well as the innate, and is characterized by the presence of anti-gluten and anti-transglutaminase 2 antibodies, lymphocytic infiltration in the epithelial membrane and the lamina propria, and expression of multiple cytokines and other signaling proteins. The disease leads to inflammation, villous atrophy, and crypt hyperplasia in the small intestine. In addition to the intestinal symptoms, celiac disease is associated with various extra-intestinal complications, including bone and skin disease, anemia, endocrine disorders, and neurologic deficits. Gluten-free diet is currently the only effective mode of treatment for celiac disease, but better understanding of the mechanism of the disease is likely to add other choices for therapy in the future. SN - 1568-9972 UR - https://www.unboundmedicine.com/medline/citation/18589004/Celiac_disease:_from_gluten_to_autoimmunity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-9972(08)00076-1 DB - PRIME DP - Unbound Medicine ER -