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Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibition.

Abstract

BACKGROUND

This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task.

METHODS

Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design.

RESULTS

Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms.

CONCLUSIONS

These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Section of Neuroimaging, Institute of Psychiatry, King's College London, United Kingdom. s.borgwardt@iop.kcl.ac.uk

    , , , , , , , , , ,

    Source

    Biological psychiatry 64:11 2008 Dec 01 pg 966-73

    MeSH

    Adult
    Analysis of Variance
    Brain
    Brain Mapping
    Cannabidiol
    Decision Making
    Double-Blind Method
    Dronabinol
    Female
    Humans
    Image Processing, Computer-Assisted
    Inhibition (Psychology)
    Magnetic Resonance Imaging
    Male
    Neuropsychological Tests
    Oxygen
    Photic Stimulation
    Psychotropic Drugs
    Reaction Time
    Young Adult

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18589404

    Citation

    Borgwardt, Stefan J., et al. "Neural Basis of Delta-9-tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition." Biological Psychiatry, vol. 64, no. 11, 2008, pp. 966-73.
    Borgwardt SJ, Allen P, Bhattacharyya S, et al. Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibition. Biol Psychiatry. 2008;64(11):966-73.
    Borgwardt, S. J., Allen, P., Bhattacharyya, S., Fusar-Poli, P., Crippa, J. A., Seal, M. L., ... McGuire, P. K. (2008). Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibition. Biological Psychiatry, 64(11), pp. 966-73. doi:10.1016/j.biopsych.2008.05.011.
    Borgwardt SJ, et al. Neural Basis of Delta-9-tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition. Biol Psychiatry. 2008 Dec 1;64(11):966-73. PubMed PMID: 18589404.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibition. AU - Borgwardt,Stefan J, AU - Allen,Paul, AU - Bhattacharyya,Sagnik, AU - Fusar-Poli,Paolo, AU - Crippa,Jose A, AU - Seal,Marc L, AU - Fraccaro,Valter, AU - Atakan,Zerrin, AU - Martin-Santos,Rocio, AU - O'Carroll,Colin, AU - Rubia,Katya, AU - McGuire,Philip K, Y1 - 2008/06/27/ PY - 2008/02/21/received PY - 2008/04/25/revised PY - 2008/05/20/accepted PY - 2008/7/1/pubmed PY - 2009/4/9/medline PY - 2008/7/1/entrez SP - 966 EP - 73 JF - Biological psychiatry JO - Biol. Psychiatry VL - 64 IS - 11 N2 - BACKGROUND: This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. METHODS: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. RESULTS: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. CONCLUSIONS: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition. SN - 1873-2402 UR - https://www.unboundmedicine.com/medline/citation/18589404/Neural_basis_of_Delta_9_tetrahydrocannabinol_and_cannabidiol:_effects_during_response_inhibition_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(08)00642-2 DB - PRIME DP - Unbound Medicine ER -